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NFKB1 — NOS3
Text-mined interactions from Literome
Kim et al., Mol Cells 1999
:
Octamer motif is required for the
NF-kappaB mediated induction of the inducible
nitric oxide synthase gene expression in RAW 264.7 macrophages
Du et al., Free Radic Biol Med 1999
:
Generation of reactive oxygen intermediates,
activation of
NF-kappaB , and induction of apoptosis in human endothelial cells by glucose : role of
nitric oxide synthase ?
Lee et al., J Biol Chem 2000
:
Incubation of macrophages with PAO1 led to
NF-kappaB dependent expression of inducible
nitric-oxide synthase , COX-2, and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function
D'Acquisto et al., Naunyn Schmiedebergs Arch Pharmacol 1999
(Disease Models, Animal...) :
We studied the
involvement of
nuclear factor-kappaB (NF-kappaB) in the regulation of inducible
nitric oxide synthase expression in carrageenin induced rat pleurisy
Pan et al., Biochem Pharmacol 2000
:
Furthermore, geraniin, 5GG, and TF-3 all blocked phosphorylation of IKB from the cytosolic fraction, inhibited
nuclear factor-kappaB (NFkappaB) activity, and
inhibited increases in inducible
nitric oxide synthase levels in activated macrophages
Stasiolek et al., J Biol Chem 2000
(Astrocytoma...) :
Expression of inflammatory
nitric oxide synthase ( NOS2 ) is
mediated by transcription factor
NFkappaB
Pahan et al., J Biol Chem 2001
:
Induction of
nitric-oxide synthase and
activation of
NF-kappaB by interleukin-12 p40 in microglial cells
Chan et al., Infect Immun 2001
:
Induction of inducible
nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is
mediated by MEK1-ERK, MKK7-JNK, and
NF-kappaB signaling pathways
Hatano et al., Gastroenterology 2001
:
NF-kappaB stimulates inducible
nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas mediated apoptosis
Ganster et al., Proc Natl Acad Sci U S A 2001
:
Complex
regulation of human inducible
nitric oxide synthase gene transcription by Stat 1 and
NF-kappa B
Liu et al., J Cell Biochem 2001
:
Distinct involvement of
NF-kappaB and p38 mitogen activated protein kinase pathways in serum deprivation
mediated stimulation of inducible
nitric oxide synthase and its inhibition by 4-hydroxynonenal
Cho et al., Int Immunopharmacol 2002
:
The effects of arctigenin and demethyltraxillagenin on the
nuclear factor-kappaB (NF-kappaB) mediated inducible
nitric oxide synthase ( iNOS, EC1.14.13.39 ) gene expression were studied in Raw264.7 cells
Wayman et al., FASEB J 2002
(Myocardial Infarction...) :
Inhibition by 15D-PGJ2 of the activation of
NF-kappaB in turn
results in a reduction of the 1 ) expression of inducible
nitric oxide synthase and the nitration of proteins by peroxynitrite, 2 ) formation of the chemokine MCP-1, and 3 ) expression of the adhesion molecule ICAM-1
Watanabe et al., Anticancer Res 2002
(Carcinoma, Squamous Cell...) :
The induction of inducible
nitric oxide synthase is
regulated by
nuclear-factor kappa B (NF-kappa B)
Neu et al., Biochem Pharmacol 2003
:
TNF-alpha induced apoptosis of isolated parietal cells was inhibited by pretreatment with different
NF-kappaB-inhibitors ,
nitric oxide synthase inhibitors and with antisense-oligodeoxynucleotides against the p65 subunit of NF-kappaB
Lee et al., Life Sci 2003
:
The regulation of inducible
nitric oxide synthase gene expression
induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells : involvement of AP-1 and
NFkappaB
Han et al., J Pharmacol Exp Ther 2003
(Inflammation) :
Treatment of cytomix stimulated cells with NAD+ also blocked
nuclear factor-kappaB (NF-kappaB) activation, inducible
nitric-oxide synthase induction , and increased production of nitric oxide ( NO. )
Kobayashi et al., Hypertension 2003
(Hypertension) :
Celiprolol activates
eNOS through the PI3K-Akt pathway and
inhibits VCAM-1 Via
NF-kappaB induced by oxidative stress
Attuwaybi et al., J Surg Res 2003
(Reperfusion Injury) :
We have previously shown that regional intraischemic hypothermia ( IH ) protects against moderate gut I/R induced mucosal injury, is associated with decreased
NF-kappaB activity and inducible
nitric oxide synthase induction and preserves heme oxygenase-1 (HO-1) expression
Mohan et al., Atherosclerosis 2003
(Arteriosclerosis...) :
LS, on the other hand, may down-regulate
eNOS expression resulting in reduced NO release, and thereby maintain high glucose
induced NF-kappaB DNA binding activity
Kumagai et al., J Biol Chem 2004
(Arteriosclerosis) :
To understand the possible signaling mechanism underlying the inducing effect of HNE on COX-2 up-regulation, we examined the phosphorylation events that may lead to COX-2 induction and found that HNE did not stimulate the induction of
nitric oxide synthase and
activation of
NF-kappaB but significantly activated p38 mitogen activated protein kinase and its upstream kinase in RAW264.7 macrophages
Jang et al., Biochem Pharmacol 2004
:
Catalase
induces the expression of inducible
nitric oxide synthase through activation of
NF-kappaB and PI3K signaling pathway in Raw 264.7 cells
Woo et al., Pharmacol Res 2005
:
Amentoflavone
inhibits the induction of
nitric oxide synthase by inhibiting
NF-kappaB activation in macrophages
Cho et al., Biochim Biophys Acta 2005
:
BIC also
induces nitric oxide synthase in macrophages through JunB/AP-1 and
NF-kappaB activation
Davis et al., Nitric Oxide 2005
:
Effects of mechanistically distinct
NF-kappaB inhibitors on glial inducible
nitric-oxide synthase expression
Grumbach et al., J Mol Cell Cardiol 2005
:
We hypothesized that this inhibitory action of NO on NFkappaB activation serves as a negative feedback to
inhibit NFkappaB activity and
eNOS transcription
Muceniece et al., J Neuroimmunol 2005
(Disease Models, Animal...) :
We found that beta-MSH suppresses LPS induced nuclear translocation of the transcription factor
NF-kappaB , and
inhibits the expression of inducible
nitric oxide synthase , and the following nitric oxide overproduction in the brain, in vivo
Rui et al., FASEB J 2005
(Inflammation) :
NFkappaB and AP-1 differentially
contribute to the induction of Mn-SOD and
eNOS during the development of oxidant tolerance
Choi et al., Eur J Pharmacol 2007
:
Isoeugenol suppression of inducible
nitric oxide synthase expression is
mediated by down-regulation of
NF-kappaB , ERK1/2, and p38 kinase
Zhang et al., Am J Pathol 2007
(Brain Ischemia...) :
In conclusion, our results demonstrate that after MCAO the interaction between tPA and LRP results in
NF-kappaB activation in astrocytes and
induction of inducible
nitric-oxide synthase expression in the ischemic tissue, suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia
Jones et al., Journal of inflammation (London, England) 2007
:
NF-kappaB activation
upregulates inducible
nitric oxide synthase leading to enhanced nitric oxide production during an inflammatory response
Tjalkens et al., J Neurosci Res 2008
:
Because
NF-kappaB dependent expression of inducible
nitric oxide synthase ( NOS2 ) can be antagonized by the nuclear orphan receptor peroxisome proliferator activated receptor-gamma ( PPARgamma ), we postulated that a novel agonist of this receptor, 1,1-bis ( 3'-indolyl ) -1- ( p-trifluoromethylphenyl ) methane ( cDIM1 ), would suppress expression of NOS2 in astrocytes and protect cocultured neuronal cells from apoptosis
Kim et al., Mol Pharmacol 2008
(Inflammation...) :
BOT-64 attenuates
NF-kappaB regulated expression of inflammatory genes such as inducible
nitric-oxide synthase , cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Okayasu et al., Life Sci 2008
:
PPARalpha activators upregulate
eNOS activity and
inhibit cytokine induced
NF-kappaB activation through AMP activated protein kinase activation
Hattori et al., FEBS Lett 2008
:
HMW adiponectin by itself was found to modestly activate
NF-kappaB , which was significantly
enhanced by inhibition of
AMPK/eNOS activation
Ye et al., Am J Physiol Heart Circ Physiol 2008
(Disease Models, Animal...) :
In the iNOS ( -/- ) mice,
eNOS and p-eNOS levels were
increased but not iNOS and COX2 levels ; however,
NF-kappaB was activated
Prabhakaran et al., Brain Res Bull 2008
(Manganese Poisoning...) :
These findings suggest that
NF-kappaB induction and the
activation of
nitric oxide synthase through ROS represent a proximate mechanism for Mn-induced neurotoxicity
Carbone et al., Mol Pharmacol 2009
:
The data presented here demonstrate the efficacy of a novel anti-inflammatory diindolylmethane class compound, 1,1-bis ( 3'-indolyl ) -1- ( p-t-butylphenyl ) methane ( DIM-C-pPhtBu ), in suppressing
NF-kappaB dependent expression of inducible
nitric-oxide synthase ( NOS2 ) and NO production in astrocytes exposed to the parkinsonian neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) through a mechanism distinct from that described for the thiazolidinedione-class compound, rosiglitazone
Jin et al., J Pain 2009
(Neuralgia) :
Variants of neural
nitric oxide synthase in the spinal cord of neuropathic rats and their
effects on
nuclear factor-kappaB (NF-kappaB) activity in PC12 cells
Du et al., Cancer Res 2009
(Neoplasms) :
The human inducible
nitric oxide synthase ( hiNOS ) gene is
regulated by
nuclear factor kappaB (NF-kappaB) and has recently been shown to be a target of the Wnt/beta-catenin pathway
de Mejia et al., Peptides 2009
(Inflammation) :
The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ),
nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible
nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Lee et al., J Pharmacol Sci 2009
(Neurotoxicity Syndromes) :
Moreover, ISL impeded the expression of
nitric oxide synthase and the
activation of
NF-kappaB through blockage of its phosphorylation
Dahlman et al., J Biol Chem 2010
:
Together, these data broaden our understanding of NF-kappaB during development by showing that in addition to its role as a negative regulator of myogenesis,
NF-kappaB also
regulates nitric-oxide synthase expression within stromal fibroblasts to stimulate myoblast fusion and muscle hypertrophy
Hseu et al., Food Chem Toxicol 2010
:
In an earlier study, we found that Antrodia camphorata
inhibited the production of lipopolysaccharide (LPS) induced cytokines, inducible
nitric oxide synthase , and cyclooxygenase-2 by blocking
nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages
Simko et al., J Hypertens 2010
(Hypertension) :
Inhibition of
nuclear factor kappa B (NF-kappaB) potentiates hypertension development, enhances oxidative load, increases the cross-sectional area of the aorta and
reduces nitric oxide ( NO ) synthase activity in L-NAME hypertension
Oussaief et al., J Virol 2011
:
NF-kappaB mediated modulation of inducible
nitric oxide synthase activity controls induction of the Epstein-Barr virus productive cycle by transforming growth factor beta 1
Hwang et al., Nitric Oxide 2013
:
Glucosamine
inhibits lipopolysaccharide stimulated inducible
nitric oxide synthase induction by inhibiting expression of
NF-kappaB/Rel proteins at the mRNA and protein levels
Kone et al., Am J Physiol 1995
:
Role of
NF-kappa B in the regulation of inducible
nitric oxide synthase in an MTAL cell line
Xie et al., J Biol Chem 1994
:
Role of transcription factor
NF-kappa B/Rel in induction of
nitric oxide synthase
Nishiya et al., FEBS Lett 1995
(Glioma) :
Herbimycin A suppresses
NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent
induction of
nitric oxide synthase in C6 glioma cells
Park et al., Biochem J 1997
:
Nitric oxide
regulates nitric oxide synthase-2 gene expression by inhibiting
NF-kappaB binding to DNA
Wong et al., Biochem Biophys Res Commun 1997
:
The heat shock response
inhibits inducible
nitric oxide synthase gene expression by blocking I kappa-B degradation and
NF-kappa B nuclear translocation
Lee et al., Biochem J 1997
:
NF-kappaB dependent expression of
nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts
Spitsin et al., Mol Med 1997
:
Human- and mouse-inducible
nitric oxide synthase promoters
require activation of phosphatidylcholine-specific phospholipase C and
NF-kappa B ... Additionally,
NF-kappa B activation is
necessary but not sufficient for inducible
nitric oxide synthase production in human cells, in contrast to murine cells in which it serves as a complete inducer
Heitmeier et al., J Biol Chem 1998
:
Double stranded RNA induced inducible
nitric-oxide synthase expression and interleukin-1 release by murine macrophages
requires NF-kappaB activation
Marks-Konczalik et al., J Biol Chem 1998
:
The
involvement of AP-1 and
NF-kappaB transcription factors in cytokine mediated induction of human inducible
nitric oxide synthase ( hiNOS ) promoter activity was examined
D'Acquisto et al., Eur J Pharmacol 1999
:
We studied the
role of
nuclear factor-kappaB (NF-kappaB) on the tone and on the expression of inducible
nitric oxide (NO) synthase , both evaluated in aortas from lipopolysaccharide treated rats