◀ Back to CXCR4

CXCR4 — ERG

Text-mined interactions from Literome

Carver et al., Nat Genet 2009 (Prostatic Neoplasms) : ADAMTS1 and CXCR4 , two candidate genes strongly associated with cell migration, were upregulated in the presence of ERG overexpression
Cai et al., Translational oncology 2010 : Results of the current study show that 1 ) prostate tumor cells coexpress higher ERG and CXCR4 compared with benign tissue, 2 ) CXCR4 expression is increased in the TMPRSS2-ERG fusion positive cell line, 3 ) ERG transcription factor binds to the CXCR4 gene promoter, 4 ) synthetic androgen ( R1881 ) upregulates both ERG and CXCR4 in TMPRSS2-ERG fusion positive VCaP cells, 5 ) small interfering RNA mediated down-regulation of ERG resulted in the loss of androgen dependent regulation of CXCR4 expression in VCaP cells, and 6 ) R1881 activated TMPRSS2-ERG expression functionally activates CXCR4 in VCaP cells