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CDH4 — RAC1
Text-mined interactions from Literome
Kovacs et al., J Biol Chem 2002
:
We report that homophilic
cadherin ligation recruits Rac to nascent adhesive contacts and specifically
stimulates Rac signaling
Goodwin et al., J Biol Chem 2003
:
Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase : direct evidence of a role for
cadherin activated
Rac signaling in adhesion and contact formation ... These data provide direct evidence for a role of
cadherin activated
Rac signaling in contact formation and adhesive stabilization
Fukuyama et al., Oncogene 2006
:
Activation of
Rac by
cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway ... However, it has not fully been understood how
cadherin induces the activation of
Rac
Matsuda et al., J Mol Cell Cardiol 2006
:
RhoA and
Rac1 activation was
inhibited by the transfection of dominant negative
N-cadherin , indicating that RhoA and Rac1 were activated by N-cadherin in the oriented cardiac myocytes
Kraemer et al., Am J Physiol Cell Physiol 2007
:
To pursue upstream elements of the Rac1 signaling pathway, we focused on the potential contribution of Tiam1 to
cadherin activated
Rac signaling
Kucharczak et al., Cancer Res 2008
(Cell Transformation, Neoplastic...) :
Together, these data suggest that
R-cadherin expression inhibits myogenesis and
induces myoblast transformation through
Rac1 activation