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PRKACB — STAR
Text-mined interactions from Literome
Sekar et al., Endocrinology 2000
:
Together, these investigations document a significant role for insulin or IGF-I in enhancing LH-stimulated progesterone and cAMP biosynthesis and endogenous StAR message and protein accumulation and in augmenting
cAMP-PKA dependent transcriptional activation of the exogenous
StAR promoter
Lopez et al., Endocrine 2001
:
The
involvement of cyclic adenosine monophosphate cAMP dependent
protein kinase A (PKA) in the regulation of the
steroidogenic acute regulatory protein ( StAR ) and the high-density lipoprotein receptor ( HDL-R ) genes by steroidogenic factor-1 (SF-1) and cAMP were examined
Tremblay et al., Endocrinology 2002
:
Moreover, we show that GATA-4 and C/EBPbeta directly interact in vitro and in vivo and synergistically activate the
StAR promoter in CV-1 cells exclusively in the
presence of
PKA
Chen et al., Int J Biochem Cell Biol 2005
(Leydig Cell Tumor...) :
Moreover, CS induced the expression of
steroidogenic acute regulatory (StAR) protein in dose- and time dependent relationships, and
PKA inhibitor, PKC inhibitor, or co-treatment with both inhibitors
suppressed it
Dyson et al., Biol Reprod 2008
:
The expression of the
steroidogenic acute regulatory protein ( STAR ) is
regulated by
PKA in response to trophic hormone stimulation through the second messenger cAMP
Kostic et al., Stress 2008
:
Thus,
PKA mediated phosphorylation of
StAR protein is an important mechanism in the adaptive response of Leydig cells to repeated IMO
Dyson et al., Mol Cell Endocrinol 2009
(Leydig Cell Tumor) :
This includes the
PKA dependent expression and activation of the
steroidogenic acute regulatory protein ( STAR ), which mediates the rate limiting step of steroidogenesis by inducing the transfer of cholesterol from the outer to the inner mitochondrial membrane
Kowalewski et al., Mol Cell Endocrinol 2010
:
Our results suggest that VIP induced
STAR expression and function in granulosa cells
result from the preferential activation of
Type I PKA
Jefcoate et al., Mol Cell Endocrinol 2011
:
StAR transcription is directly
activated by
PKA phosphorylation
Manna et al., J Biol Chem 2013
(Second Messenger Systems) :
These findings provide novel insight and demonstrate the molecular events by which HSL acts to drive
cAMP/PKA mediated regulation of
StAR expression and steroidogenesis in mouse Leydig cells