◀ Back to IGF2

IGF2 — SLPI

Text-mined interactions from Literome

Tian et al., Hua Xi Kou Qiang Yi Xue Za Zhi 1998 : The results showed that IGF-II stimulated DNA, collagen synthesis and ALP activity of human osteoblast-like cells
Li et al., Vet J 2009 : At concentrations of 10ng/mL and 100ng/mL, IGF-1 significantly induced ALP activity, OC level, matrix calcium content, and nodule formation of the osteoblastic cells by 20-180 % ( P < 0.05 or P < 0.01 ), compared to controls
Han et al., Hua Xi Kou Qiang Yi Xue Za Zhi 2009 : The mechanical stretch can promote MSCs proliferation, up-regulate its ALP activity and induce a time dependent expression increase of TGF-beta and IGF-II which in turn result in osteogenic differentiation of MSCs. Mechanical stimulus is a key stimulator for osteogenic differentiation of MSCs and vital for bone formation in distraction osteogenesis
Chen et al., J Bone Miner Res 2010 (Hypertrophy) : Expression of the IGF antagonists IGFBP3 and IGFBP4 leads to inhibition of the IGF-2 effect on BMP-9 induced ALP activity and matrix mineralization
Anh et al., Calcif Tissue Int 1998 : IGF-II had no effect on extracellular ALP stability, but the addition of Ca to Ca-free cultures resulted in parallel losses of extracellular ALP activity and ALP immunoreactive protein ( P < 0.001 for each )