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ERBB2 — PRKAR1B
Text-mined interactions from Literome
Yang et al., Arch Pharm Res 2008
(Breast Neoplasms) :
We previously reported that cAMP dependent
protein kinase (PKA) mediated activator protein-2 (AP-2) activation was
responsible for the expression of
Her-2/ErbB2 in p53 inactivated mammary epithelial cells ( Yang et al., 2006 ) ... In the present study, we tested the hypothesis that
PKA plays a role in the expression of
ErbB2 in tamoxifen-resistant breast cancer cells ... In contrast,
PKA inhibition by H-89 or cAMP dependent protein kinase inhibitor l gamma overexpression
increased the expression levels of
ErbB2 in TAM-resistant MCF-7 ( TAMR-MCF-7 ) cells
Monje et al., J Biol Chem 2008
:
Here, we report that the activation of
protein kinase A (PKA) , but not that of exchange protein activated by cAMP ( EPAC ),
enhances S-phase entry of SCs by synergistically enhancing the ligand dependent tyrosine phosphorylation/activation of the neuregulin co-receptor,
ErbB2-ErbB3 ... Two basic observations defined the synergistic action of PKA as `` gating '' for neuregulin-ErbB signaling : 1 ) the activation of
PKA was not
sufficient to induce S-phase entry or the activation of either
ErbB2 or ErbB3 ; and 2 ) the presence of neuregulin was strictly required to ignite ErbB activation and thereby ERK and Akt signaling ... However, PKA directly phosphorylated ErbB2 on Thr-686, a highly conserved intracellular regulatory site that was required for the
PKA mediated synergistic enhancement of neuregulin induced
ErbB2-ErbB3 activation and proliferation in SCs