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CSNK1A1 — CTNNB1

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: CSNK1A1/CSNK1A1L → CTNNB1 (protein-protein, binding/association)
• NCI Pathway Database Degradation of beta catenin: CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, activates)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, activates)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, activates)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: CSNK1A1 → CTNNB1 (indirect_complex) Willert et al., Genes Dev 1999, Jho et al., Biochem Biophys Res Commun 1999, Kimelman et al., Oncogene 2006*, Luo et al., EMBO J 2007, Su et al., Mol Cell 2008, MacDonald et al., Dev Cell 2009, Ikeda et al., EMBO J 1998
• Reactome Reaction: CTNNB1 → CSNK1A1 (reaction) Liu et al., Cell 2002, Amit et al., Genes Dev 2002, Liu et al., J Mol Biol 2006
• Reactome Reaction: CTNNB1 → CSNK1A1 (indirect_complex) Liu et al., Cell 2002, Amit et al., Genes Dev 2002
• Reactome Reaction: CSNK1A1 → CTNNB1 (reaction) Willert et al., Genes Dev 1999, Luo et al., EMBO J 2007, Schwarz-Romond et al., Nature structural & molecular biology 2007, Bilic et al., Science 2007, Huang et al., Curr Opin Cell Biol 2008, Piao et al., PloS one 2008, Niehrs et al., Cell 2010, Taelman et al., Cell 2010, Schuldt et al., Nat Rev Mol Cell Biol 2011, Saito-Diaz et al., Growth Factors 2013
• Reactome Reaction: CTNNB1 → CSNK1A1 (direct_complex) Xing et al., Mol Cell 2004, Liu et al., J Mol Biol 2006
• WikiPathways Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds: DVL2 → Complex of AXIN1-TNKS-GSK3B-APC-CSNK1A1-CTNNB1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CSNK1A1 — CTNNB1 (in vivo) Liu et al., Cell 2002, Amit et al., Genes Dev 2002
• IRef Hprd Interaction: CSNK1A1 — CTNNB1 (in vitro) Liu et al., Cell 2002, Amit et al., Genes Dev 2002
• IRef Innatedb Interaction: CSNK1A1 — CTNNB1 (unknown, -) Park et al., Eur J Cell Biol 2007*
• IRef Intact Interaction: Complex of 11 proteins (association, anti bait coimmunoprecipitation) Li et al., Cell 2012
• IRef Intact Interaction: Complex of 16 proteins (association, anti bait coimmunoprecipitation) Li et al., Cell 2012
• IRef Intact Interaction: Complex of 120 proteins (association, anti bait coimmunoprecipitation) Brazão et al., FEBS Lett 2012

Text-mined interactions from Literome

Lee et al., J Cell Biol 2001 : Tcf3 synergizes with CK1epsilon to inhibit beta-catenin degradation, whereas CKI-7, an inhibitor of CK1epsilon, reduces the inhibitory effect of Tcf3
Liu et al., Cell 2002 : Depletion of CKIalpha inhibits beta-catenin phosphorylation and degradation and causes abnormal embryogenesis associated with excessive Wnt/beta-catenin signaling
Levina et al., Oncogene 2004 : We found that the p53 mediated reduction in beta-catenin involves enhanced phosphorylation of beta-catenin on key NH ( 2 ) -terminal serines and requires CK1 and GSK-3beta activities, both being components of the beta-catenin degradation machinery
Li et al., J Neurochem 2010 (Medulloblastoma) : This inhibitor does not interfere with TrkA activation but does block NGF dependent AlexaFluor546-dextran uptake and CK1 dependent phosphorylation of beta-catenin