Schweitzer et al., EMBO J 2007
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For the first time, we show here an inducible interaction of the CSN with IkappaBalpha and that the CSN controls IkappaBalpha and NF-kappaB activity ... We propose that the CSN controls both CRL activity and stability of the CRL substrate IkappaBalpha Welteke et al., EMBO Rep 2009
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The CSN is required for the degradation of the NF-kappaB inhibitor IkappaBalpha , but other molecular targets involved in T-cell signalling remained elusive
Tsuchiya et al., Mol Cell 2010
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Furthermore, casein kinase 2 ( CK2 ) and p38 associate with IKKbeta and promote IkappaBalpha degradation by phosphorylation at C-terminal sites