Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of CUL1-FBXW7-RBX1-SKP1
→
TP53
(increases)
Evidence: p53 might induce Cyclin E degradation via upregulation of Fbw7.
Evidence: Notch4 degradation is impaired in Fbw7-/- cells. In contrast, the expression of Notch1, Notch2 and Notch3 is comparable among different genotypes. The finding that Fbw7-/- embryos exhibit severe defects in vascular development is likely due to the upregulation of the transcriptional repressor Hey-1, a downstream effector of Notch signaling.
Evidence: The involvement of Fbw7 in the control of the Notch pathway is confirmed by the finding that Notch4 accumulates in Fbw7-deficient embryos, which die in utero at embryonic day 10.5 and manifest abnormal vascular development
BioCarta cyclin e destruction pathway:
FBW7/SKP1/CUL1/CDC34 complex (FBXW7-SKP1A-CUL1-CDC34)
→
Cyclin E (CCNE1)
(protein ubiquitination, activates)