Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL21 ▸ IL18 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL7 ▸ IL22 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ INS ▸ IL11 ▸ CCL2 ▸ IL15 ▸
IL19 ▸ IL31 ▸ IL24 ▸ JAK2 ▸ IL16 ▸ IL9 ▸ IL34 ▸
IL6ST ▸ IL20 ▸ JUN ▸ IL26 ▸ IL25 ▸ IL37 ▸ NOS2 ▸
IL27 ▸ SOCS3 ▸ TLR7 ▸ TLR1 ▸ TLR5 ▸ STAT1 ▸ TLR8 ▸
TLR6 ▸ TLR10 ▸ IL12B ▸ PTH ▸ SOAT1 ▸ SAA1 ▸ CSRP1 ▸
IL1RN ▸ AKT1 ▸ AKT2 ▸ JAK1 ▸ AKT3 ▸ FOS ▸ LEP ▸
CD79A ▸ IL12A ▸ LRPPRC ▸ PIK3CA ▸ VIP ▸ RNF19A ▸ PIK3R1 ▸
CRK ▸ LTA ▸ WDR61 ▸ CTR9 ▸ PTX3 ▸ CDC73 ▸ MMP1 ▸
CD40LG ▸ LIF ▸ LEO1 ▸ ADCYAP1 ▸ PAF1 ▸ PRKAG1 ▸ PRKAB2 ▸
PRKAG2 ▸ PRKAA2 ▸ PRKAB1 ▸ FGF2 ▸ PRKAA1 ▸ IL6R ▸ GP5 ▸
PTX4 ▸ GP6 ▸ HGF ▸ GP9 ▸ GP2 ▸ MMP3 ▸ MYLIP ▸
IGF1 ▸ MMP9 ▸ EDN1 ▸ CRH ▸ TCF3 ▸ MMP2 ▸ JAK3 ▸
GRAP2 ▸ TCF4 ▸ TCF7 ▸ TCF12 ▸ CD4 ▸ TCF15 ▸ TCF20 ▸
TCF23 ▸ MYD88 ▸ TCF19 ▸ TCF21 ▸ TCF24 ▸ CISH ▸ TCF25 ▸
MMP13 ▸ IFNB1 ▸ CA2 ▸ TGFB3 ▸ A2M ▸ PLG ▸ TGFB2 ▸
MCL1 ▸ NOS3 ▸ OSM ▸ PAM ▸ TIMP1 ▸ AHSA1 ▸ HP ▸
CD14 ▸ NOS1 ▸ CD46 ▸ CEBPB ▸ HMGB1 ▸ HNRNPH1 ▸ HNRNPF ▸
PGF ▸ PTBP1 ▸ PTBP2 ▸ MT3 ▸ NFKBIA ▸ CSF1 ▸ NA ▸
CASP3 ▸ APOB ▸ ALB ▸ STAT5A ▸ AR ▸ NOX4 ▸ PRG3 ▸
PRG4 ▸ S100A12 ▸ PI3 ▸ TAT ▸ TNFSF11 ▸ PRG2 ▸ CASP4 ▸
CASP16 ▸ CASP12 ▸ CASP10 ▸ CASP2 ▸ CASP5 ▸ PRKAR2B ▸ NOX1 ▸
PRKACB ▸ CASP14 ▸ PRKAR2A ▸ NOX3 ▸ CASP1 ▸ PRKAR1B ▸ NGF ▸
CSF3 ▸ CASP9 ▸ PRKAR1A ▸ CASP6 ▸ NOX5 ▸ PRKACG ▸ CASP7 ▸
CASP8 ▸ VCAM1 ▸ LPA ▸ POLDIP2 ▸ FOXP3 ▸ SOCS1 ▸ ITIH4 ▸
PDGFB ▸ FAS ▸ ANGPT2 ▸ MT4 ▸ GPI ▸ PRL ▸ SOD1 ▸
FASLG ▸ SYT1 ▸ MMP11 ▸ MMP14 ▸ MMP7 ▸ SELE ▸ SPP1 ▸
CALM3 ▸ CYP19A1 ▸ SOD3 ▸ MMP10 ▸ CD8A ▸ SAA2 ▸ TNFRSF11B ▸
SOD2 ▸ IKBKB ▸ ANG ▸ IFI44 ▸ IRF1 ▸ NUP43 ▸ CEBPA ▸
PLA2G1B ▸ BCL2 ▸ MMP8 ▸ APP ▸ MMP12 ▸ PTPN11 ▸ LBP ▸
HMOX1 ▸ MMP28 ▸ MMP19 ▸ MMP25 ▸ CTSB ▸ ADIPOQ ▸ FCER2 ▸
CD28 ▸ CPOX ▸ MMP15 ▸ CALML3 ▸ SETBP1 ▸ F2RL1 ▸ MMP20 ▸
CCL3 ▸ MMP17 ▸ SERPINE1 ▸ MMP24 ▸ MMP21 ▸ NAALADL1 ▸ HDAC1 ▸
LPL ▸ MMP27 ▸ MMP16 ▸ EGF ▸ ALG1 ▸ MMP26 ▸ MSH3 ▸
APC ▸ AGTR2 ▸ AGT ▸ SAA4 ▸ PTHLH ▸ PRDX2 ▸ BCL6 ▸
CSK ▸ ERVK-6 ▸ BCL3 ▸ PLA2G4A ▸ NPS ▸ TYR ▸ SERPINA3 ▸
HDAC2 ▸ LTF ▸ FGF1 ▸ MAP3K7 ▸ GH1 ▸ MSH6 ▸ GFAP ▸
FGF23 ▸ HES1 ▸ PTPRC ▸ MIF ▸ FGF4 ▸ IL23A ▸ FGF7 ▸
IRAK4 ▸ PPARG ▸ FGF8 ▸ FGF21 ▸ ABCC1 ▸ CEACAM5 ▸ SKP1 ▸
CHUK ▸ FGF18 ▸ FGF11 ▸ IL1R1 ▸ SMAD3 ▸ MSH2 ▸ FGF13 ▸
FGF19 ▸ IGF2 ▸ F2R ▸ FGF12 ▸ PDLIM7 ▸ FGF22 ▸ FGF16 ▸
PPARA ▸ CREB1 ▸ LTB ▸ CREB5 ▸ FGF6 ▸ FGF14 ▸ TP53 ▸
IFNA2 ▸ IL2RA ▸ FGF3 ▸ MSH5 ▸ CREB3 ▸ FGF17 ▸ MTX1 ▸
FGF9 ▸ CUL1 ▸ FGF10 ▸ FGF20 ▸ MSH4 ▸ KITLG ▸ FGF5 ▸
BMP2 ▸ PTK6 ▸ IFNA1 ▸ CEBPD ▸ CDKN1A ▸ MTOR ▸ CCL5 ▸
ESR1 ▸ IFNA8 ▸ IFNA14 ▸ SST ▸ IFNA6 ▸ HES3 ▸ IFNA4 ▸
HES7 ▸ ANXA1 ▸ CD8B ▸ TXN ▸ CD44 ▸ HES4 ▸ HES2 ▸
MAP2K1 ▸ IFNA7 ▸ IFNA16 ▸ HSPD1 ▸ IFNA21 ▸ IFNA17 ▸ CXCL12 ▸
PTK7 ▸ IFNA13 ▸ RHO ▸ MPO ▸ EPO ▸ IFNA10 ▸ EGFR ▸
PTK2 ▸ IFNA5 ▸ MRXS5 ▸ TRAF6 ▸ HES5 ▸ SMAD2 ▸ HES6 ▸
UCN ▸ PRKCA ▸ PAEP ▸ MAP2K4 ▸ SP1 ▸ CNTN2 ▸ HAMP ▸
BAX ▸ AVP ▸ NPY ▸ CAV1 ▸ P2RX7 ▸ SMAD7 ▸ SMAD4 ▸
IDO1 ▸ FCGR1A ▸ CAV3 ▸ WNK1 ▸ MUC1 ▸ RBBP4 ▸ C4BPA ▸
CXCL1 ▸ TFPI ▸ CNTF ▸ NAMPT ▸ CXCL10 ▸ KLK3 ▸ ANPEP ▸
HSPB1 ▸ IKBKG ▸ STAT4 ▸ RENBP ▸ CAV2 ▸ RBBP7 ▸ SMAD9 ▸
TAB1 ▸ NOD1 ▸ GZMB ▸ PDCD11 ▸ CD86 ▸ CLEC7A ▸ MET ▸
REL ▸ SHC1 ▸ IRAK1 ▸ NOD2 ▸ SYK ▸ ACE ▸ MUC4 ▸
SIN3A ▸ TNFRSF1B ▸ SELP ▸ IRF3 ▸ DDIT3 ▸ GIF ▸ SAP130 ▸
IRS1 ▸ BCL10 ▸ ADCY4 ▸ ACP2 ▸ ADCY7 ▸ RAG2 ▸ AGTR1 ▸
BMP7 ▸ IFI27 ▸ ADCY6 ▸ GCG ▸ NM ▸ SELL ▸ MBP ▸
SMAD5 ▸ IL17RA ▸ HLA-DRA ▸ CAT ▸ SMAD6 ▸ WNT5A ▸ HLA-DRB1 ▸
ADCY8 ▸ CYP3A4 ▸ BMP6 ▸ CHAT ▸ ARID4B ▸ CD5 ▸ HDC ▸
HIF1A ▸ ADCY3 ▸ TGFA ▸ ADCY5 ▸ ADCY1 ▸ CORT ▸ SAP30 ▸
ADCY9 ▸ DUSP1 ▸ ADM ▸ TNFRSF1A ▸ ADCY10 ▸ RAG1 ▸ NPPA ▸
STS ▸ S100B ▸ NPEPPS ▸ CSE ▸ ADCY2 ▸ CCR5 ▸ SUDS3 ▸
SMAD1 ▸ JUND ▸ SRC ▸ CTSL ▸ CXCL17 ▸ ANXA6 ▸ OPRM1 ▸
RETN ▸ HSP90AB1 ▸ IRF4 ▸ IBD6 ▸ SETD2 ▸ MPG ▸ ICOSLG ▸
MAP2K5 ▸ IBD9 ▸ NCAM1 ▸ BTRC ▸ IBD3 ▸ UTP23 ▸ ADORA1 ▸
BMP1 ▸ UTP15 ▸ CCND1 ▸ MUC8 ▸ HRAS ▸ IL17D ▸ MUC19 ▸
UTP20 ▸ MUC21 ▸ CYP1A1 ▸ TNFSF13B ▸ ICAM5 ▸ SFTPC ▸ S100A8 ▸
PLD2 ▸ EDN3 ▸ MUC6 ▸ IBD2 ▸ CTGF ▸ IBD5 ▸ MAP2K6 ▸
MUC13 ▸ ARSA ▸ MUC20 ▸ IGFBP1 ▸ LGALS1 ▸ ATP8A2 ▸ ICAM4 ▸
MUC12 ▸ PTPN4 ▸ CR2 ▸ EIF2AK2 ▸ MAP2K2 ▸ NLRP3 ▸ ATF3 ▸
MUC2 ▸ PGP ▸ HSPG2 ▸ UTP6 ▸ S100A9 ▸ UTP18 ▸ APOE ▸
FGFR3 ▸ CTF1 ▸ ICAM2 ▸ REG1A ▸ MAP2K3 ▸ TYK2 ▸ BCL5 ▸
SEA ▸ ZFP36 ▸ PLD1 ▸ PIGA ▸ IRAK3 ▸ MOG ▸ UTP3 ▸
AHR ▸ MUC17 ▸ ICAM3 ▸ EDN2 ▸ TPO ▸ HSF1 ▸ BCL9 ▸
GRB2 ▸ MAP2K7 ▸ IBD7 ▸ ABCB1 ▸ TNFRSF8 ▸ PTGS1 ▸ ITGB1 ▸
PPP2CA ▸ IBD8 ▸ HMGCR ▸ POMC ▸ IL17F ▸ INA ▸ ST2 ▸
MUC7 ▸ MUC22 ▸ CCL20 ▸ PDGFA ▸ MUC16 ▸ MUC15 ▸ CYP3A ▸
VAV1 ▸ TF ▸ IBD4 ▸ ITGAM ▸ PGD ▸ HCK ▸ CHGA ▸
ATP7A ▸ TEC ▸ FXR2 ▸ TRAF2 ▸ SERPINF1 ▸ PARP3 ▸ CPB1 ▸
ATP5O ▸ WNT10B ▸ HPD ▸ ETS2 ▸ PLD4 ▸ GPX6 ▸ PARP12 ▸
PPP2R2B ▸ BMP5 ▸ GAL ▸ EPS15 ▸ TSLP ▸ PON1 ▸ DNMT1 ▸
FXR1 ▸ OAS3 ▸ XRCC1 ▸ TNPO1 ▸ TRPV1 ▸ PARP15 ▸ CD1D ▸
NEUROD4 ▸ MS4A1 ▸ GPX4 ▸ PLD5 ▸ HCL3 ▸ HSPA5 ▸ GPX2 ▸
WNT4 ▸ ADORA3 ▸ GNRH1 ▸ NEUROD2 ▸ HSPB3 ▸ GTF2B ▸ CIB1 ▸
PIM1 ▸ HSP90AA1 ▸ PARP14 ▸ PDCD4 ▸ NTF3 ▸ C1orf228 ▸ GYS2 ▸
HDAC6 ▸ IL1R2 ▸ RPL17 ▸ GPX3 ▸ CTSS ▸ FUT4 ▸ GNA13 ▸
CD163 ▸ ROR1 ▸ THBD ▸ GYS1 ▸ KNG1 ▸ PARK2 ▸ CPB2 ▸
XBP1 ▸ PARP8 ▸ LCN2 ▸ GHRH ▸ IRF9 ▸ TIMP2 ▸ BMP10 ▸
GPX1 ▸ GPX5 ▸ LYN ▸ MAPKAPK2 ▸ BMP4 ▸ CA1 ▸ EPX ▸
CXCR4 ▸ NDP ▸ C5AR1 ▸ ANGPT1 ▸ ACHE ▸ C1QB ▸ PARP4 ▸
SLPI ▸ IRF5 ▸ BMP15 ▸ PARP6 ▸ EBP ▸ NEUROD1 ▸ UCN2 ▸
BPI ▸ CRYGEP ▸ ETS1 ▸ OPN1LW ▸ EPS8 ▸ PARP16 ▸ GPX7 ▸
ESR2 ▸ CYP1A2 ▸ C1QA ▸ TGM2 ▸ SCARB1 ▸ CD19 ▸ NFATC2 ▸
ABL1 ▸ CLU ▸ IRF8 ▸ BTK ▸ BGLAP ▸ FOXO3 ▸ PLD6 ▸
CX3CR1 ▸ IDS ▸ CSH2 ▸ PPP2R1A ▸ PARP2 ▸ CD80 ▸ MAF ▸
CD2 ▸ PARP10 ▸ HDAC3 ▸ BCR ▸ CCL1 ▸ OAS2 ▸ PLD3 ▸
PTS ▸ GPX8 ▸ HCL1 ▸ BMP3 ▸ PCK1 ▸ PITX2 ▸ CXCL6 ▸
NEUROD6 ▸ HCL2 ▸ AHSG ▸ FXYD1 ▸ PARP9 ▸ TRNAI1 ▸ PARP11 ▸
MPL ▸ OAS1 ▸ PARP1 ▸ NNMT ▸ IGFBP3 ▸ TFAP2A ▸ TNFAIP6 ▸
TSN ▸ CXCR3 ▸ NR0B1 ▸ EGR1 ▸ CDKN1B ▸ IRF2 ▸ CXCL11 ▸
ITGA4 ▸ MAP3K3 ▸ TNFSF10 ▸ MYO10 ▸ COQ5 ▸ TSC22D3 ▸ NR4A1 ▸
IL1RAP ▸ AREG ▸ SMC4 ▸ PINK1 ▸ PDCD7 ▸ TRAF5 ▸ ECM1 ▸
ACE2 ▸ MCS ▸ CNR2 ▸ THBS1 ▸ STK31 ▸ CDK4 ▸ STK3 ▸
UCN3 ▸ ADAM17 ▸ ITGA5 ▸ LCAT ▸ TGM4 ▸ E2F1 ▸ CALM2 ▸
ACAN ▸ ABCA4 ▸ SLC39A14 ▸ CDH1 ▸ CCL4 ▸ CHP2 ▸ CXCL16 ▸
CEBPZ ▸ STK4 ▸ NMU ▸ CD274 ▸ PDCD5 ▸ PHB ▸ APOA4 ▸
OXA1L ▸ ACSM3 ▸ CXCL2 ▸ DYNLRB1 ▸ HDAC11 ▸ STK16 ▸ APCS ▸
KRT10 ▸ COQ7 ▸ GSTM2 ▸ SPN ▸ HDAC7 ▸ IGF1R ▸ PDCD6 ▸
COQ2 ▸ COQ4 ▸ CD69 ▸ BAI3 ▸ C5 ▸ MICE ▸ NOTCH2 ▸
CXCL3 ▸ MTA1 ▸ RAF1 ▸ SMC3 ▸ KLRB1 ▸ SMN1 ▸ RLN3 ▸
BLVRB ▸ BAI1 ▸ NLRC5 ▸ GSTM3 ▸ MYC ▸ CREBBP ▸ TIMP3 ▸
HDAC10 ▸ RPS6KA3 ▸ HBD ▸ TRAF1 ▸ FLOT2 ▸ ATF4 ▸ LYZ ▸
MEPE ▸ QRICH1 ▸ PDAP1 ▸ PLA2G2D ▸ XIAP ▸ STK24 ▸ WNT2 ▸
P2RY6 ▸ TNC ▸ PDCD2 ▸ RORC ▸ RUNX2 ▸ PRNP ▸ CXCL9 ▸
MYO16 ▸ COQ9 ▸ GSTM1 ▸ STK11 ▸ TBP ▸ CCR6 ▸ TAC3 ▸
WNT11 ▸ MUC5AC ▸ VCP ▸ MYO19 ▸ IGFBP7 ▸ STK40 ▸ CD38 ▸
AZU1 ▸ MAL ▸ CDK9 ▸ HCFC1 ▸ IRF7 ▸ KRT38 ▸ ATF1 ▸
BSG ▸ COL1A1 ▸ NOTCH1 ▸ NT5E ▸ CD33 ▸ RNASE3 ▸ MTA2 ▸
SERPINA1 ▸ SAA3P ▸ EEF1A2 ▸ HDAC8 ▸ ADIPOR1 ▸ QRICH2 ▸ RAC1 ▸
DERL1 ▸ BDNF ▸ CHP1 ▸ STK35 ▸ CD1C ▸ STK39 ▸ CD59 ▸
ARG2 ▸ VHLL ▸ SERPINA6 ▸ IL2RG ▸ IGFBP2 ▸ ARG1 ▸ CALM1 ▸
GAST ▸ VIMP ▸ TBCC ▸ SDC1 ▸ STK33 ▸ TRD ▸ ADH4 ▸
ANGPT4 ▸ WNT16 ▸ ADH6 ▸ STK38 ▸ GSTM5 ▸ NTF4 ▸ PSMB9 ▸
MCC ▸ RBP4 ▸ PTPN22 ▸ MKL1 ▸ ITGA2B ▸ FLT3LG ▸ GIP ▸
SCG5 ▸ WNT3 ▸ CXCL13 ▸ TGM7 ▸ SOS1 ▸ HDAC4 ▸ COQ3 ▸
SMC5 ▸ ECM2 ▸ ABCG2 ▸ RLN1 ▸ CD34 ▸ KRT13 ▸ ASIP ▸
GCLC ▸ TAC4 ▸ RASIP1 ▸ TRAF3IP2 ▸ CCR1 ▸ DEFB114 ▸ FMR1 ▸
AMELX ▸ IGFBP4 ▸ IL2RB ▸ CEACAM1 ▸ SMC6 ▸ MIA ▸ MYO6 ▸
NANOG ▸ FGL1 ▸ IGFBP5 ▸ MSC ▸ PC ▸ STK19 ▸ PDCD10 ▸
PTK2B ▸ PDCD1 ▸ SCG3 ▸ ROR2 ▸ PIAS3 ▸ CX3CL1 ▸ PLAT ▸
SCG2 ▸ AIF1 ▸ PPP5C ▸ GSTM4 ▸ OXTR ▸ RABEPK ▸ ICOS ▸
LDLR ▸ SARS ▸ SLC25A3 ▸ C3AR1 ▸ FGFR2 ▸ HDAC9 ▸ LRG1 ▸
IFIT1 ▸ STEAP4 ▸ VWF ▸ HDAC5 ▸ SLC33A1 ▸ SMC2 ▸ KDR ▸
RAB7A ▸ CDKN2A ▸ STK10 ▸ CCR2 ▸ BAI2 ▸ SFTPA1 ▸ SP3 ▸
ACD ▸ DEFB4B ▸ CPA1 ▸ KRT37 ▸ JUNB ▸ IRG1 ▸ WAS ▸
COQ6 ▸ ADH7 ▸ TIRAP ▸ SERPING1 ▸ GAS6 ▸ STK25 ▸ MIP ▸
CXCL5 ▸ AD5 ▸ WNT6 ▸ ACR ▸ EREG ▸ RAB7B ▸ RB1 ▸
MTA3 ▸ FYN ▸ CALCA ▸ WNT1 ▸ PCK2 ▸ CRAT ▸ NTS ▸
SERPINB5 ▸ SERPINE2 ▸ HSPB8 ▸ CP ▸ NTN1 ▸ EDNRA ▸ TAC1 ▸
NPY4R ▸ TTR ▸ CXCL14 ▸ REN ▸ ADH5 ▸ RLN2 ▸ STK36 ▸
IRAK2 ▸ POU5F1 ▸ LGALS3 ▸ CCK ▸ P2RX1 ▸ PARK7 ▸ HPX ▸
PIK3C3 ▸ CBL ▸ PRKD1 ▸ PTGER4 ▸ NFKB2 ▸ ZBTB16 ▸ PTPRE ▸
KAT2B ▸ FOXO1 ▸ MEOX2 ▸ HNRNPA1 ▸ ERBB3 ▸ SH3GL2 ▸ F12 ▸
PIAS1 ▸ GCSAM ▸
Data information
Please see the Gene Interactions Track Manual.