Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866310-178952497)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

EGF ▸ RAC1 ▸ EGFR ▸ IL6 ▸ NOS3 ▸ TNF ▸ MMP9 ▸
LEP ▸ IRS1 ▸ PI3 ▸ PTGS2 ▸ IL8 ▸ HMOX1 ▸ ANXA6 ▸
FOXO3 ▸ IRF6 ▸ CASP3 ▸ CASP9 ▸ CASP1 ▸ CASP10 ▸ CASP2 ▸
CASP8 ▸ SRC ▸ BCL2 ▸ CASP12 ▸ CASP16 ▸ CASP7 ▸ CASP14 ▸
CASP6 ▸ CASP5 ▸ CASP4 ▸ BCR ▸ GSK3B ▸ HIF1A ▸ IL2 ▸
IL12A ▸ HGF ▸ JUN ▸ IL12B ▸ IL10 ▸ FOXO1 ▸ NOS2 ▸
STAT3 ▸ CD28 ▸ MLST8 ▸ FGF2 ▸ CCND1 ▸ RAC2 ▸ NGF ▸
TLR4 ▸ KRAS ▸ CTNNB1 ▸ TLR2 ▸ RAF1 ▸ ESR1 ▸ BDNF ▸
NOX4 ▸ MMP2 ▸ NOX3 ▸ RAC3 ▸ PTPN11 ▸ NOX5 ▸ CBFA2T2 ▸
IRS2 ▸ TP53 ▸ NOX1 ▸ CREB3 ▸ CREB1 ▸ ARHGEF7 ▸ CDC42 ▸
RPTOR ▸ HRAS ▸ CRK ▸ CD79A ▸ CREB5 ▸ MAP2K1 ▸ RHOA ▸
IL1B ▸ JAK2 ▸ GRAP2 ▸ PRKAB1 ▸ CDKN1A ▸ PRKAB2 ▸ PRKAG1 ▸
PRKAA2 ▸ IGF2 ▸ PRKAA1 ▸ CD79B ▸ PRKAG2 ▸ MMP14 ▸ BMP2 ▸
MCL1 ▸ PRKAR2B ▸ PRKACB ▸ PRKAR1B ▸ IFI27 ▸ GAB1 ▸ PRKACG ▸
PRKAR1A ▸ CBL ▸ PRKAR2A ▸ HSPG2 ▸ SLC2A4 ▸ PARP1 ▸ PLCG1 ▸
BCL10 ▸ STAT1 ▸ SMAD2 ▸ FAS ▸ TLR5 ▸ IFNG ▸ SLC25A16 ▸
FOS ▸ PDGFB ▸ SETD2 ▸ RAD50 ▸ PTK2 ▸ IGF1R ▸ MMP13 ▸
MRE11A ▸ TCF12 ▸ TMED7 ▸ TCF21 ▸ XRCC5 ▸ TCF23 ▸ MMP10 ▸
PDGFRB ▸ TLR3 ▸ TERF2IP ▸ POT1 ▸ TERF2 ▸ CXCL12 ▸ AHSA1 ▸
XRCC6 ▸ TCF20 ▸ BAX ▸ PIK3CB ▸ IL4 ▸ TCF3 ▸ ANGPT2 ▸
SYK ▸ MMP12 ▸ PIK3R1 ▸ IL3 ▸ TCF19 ▸ TGFB1 ▸ PRKCA ▸
TERF1 ▸ JAK1 ▸ IL17A ▸ TCF7 ▸ ACD ▸ RPS6KB1 ▸ ESR2 ▸
PHKA2 ▸ TCF4 ▸ PIK3CD ▸ TCF15 ▸ XIAP ▸ TCF24 ▸ TINF2 ▸
TCF25 ▸ MMP7 ▸ NOS1 ▸ VCAM1 ▸ RAB5A ▸ PRL ▸ MMP3 ▸
PLAU ▸ MMP20 ▸ SLC2A1 ▸ MMP21 ▸ MMP25 ▸ GJA1 ▸ TLR7 ▸
TLR10 ▸ ILK ▸ FOXO6 ▸ MMP26 ▸ JAK3 ▸ MMP8 ▸ PLD2 ▸
MMP15 ▸ MMP24 ▸ FOXO4 ▸ MMP17 ▸ ZGLP1 ▸ ICAM1 ▸ MYLIP ▸
TLR9 ▸ TLR1 ▸ TLR8 ▸ MMP27 ▸ MMP11 ▸ SP1 ▸ MYD88 ▸
MMP16 ▸ MMP19 ▸ TLR6 ▸ EIF4EBP1 ▸ MMP1 ▸ MMP28 ▸ IKBKG ▸
SREBF1 ▸ CTGF ▸ IL13 ▸ BCL9 ▸ PDLIM7 ▸ SMAD4 ▸ PTK6 ▸
ECM2 ▸ PIP ▸ LPA ▸ STK39 ▸ FOSL1 ▸ ECM1 ▸ RICTOR ▸
GYS1 ▸ STK10 ▸ BCL5 ▸ STK19 ▸ STK16 ▸ NFKBIA ▸ SMAD1 ▸
BCL3 ▸ SYT1 ▸ HSP90AA1 ▸ SLC22A3 ▸ HRG ▸ WNK1 ▸ INSR ▸
SERPINE1 ▸ STK40 ▸ IL7 ▸ KITLG ▸ CXCL11 ▸ CDH1 ▸ STK33 ▸
GRB2 ▸ BCL6 ▸ STK25 ▸ TGFB2 ▸ GDNF ▸ STK4 ▸ BTK ▸
LCK ▸ FGF21 ▸ SMAD5 ▸ CSF1 ▸ FYN ▸ PLA2G1B ▸ PLCG2 ▸
MET ▸ IL18 ▸ PTK7 ▸ EPO ▸ STK35 ▸ STK3 ▸ CA2 ▸
STK31 ▸ STK24 ▸ GYS2 ▸ STK11 ▸ STK38 ▸ STK36 ▸ NTRK1 ▸
FGF13 ▸ RUNX2 ▸ PLD3 ▸ PLD5 ▸ IL5 ▸ FGF23 ▸ FASLG ▸
TNFSF10 ▸ CXCR4 ▸ FGF6 ▸ PPP1R3A ▸ CDC73 ▸ SOAT1 ▸ FGF14 ▸
PLD4 ▸ NA ▸ RLN3 ▸ SMAD6 ▸ IL32 ▸ LGALS3 ▸ HDAC1 ▸
VAV1 ▸ ODC1 ▸ FGF22 ▸ FGF17 ▸ FGF9 ▸ HDAC2 ▸ PIK3IP1 ▸
ADORA1 ▸ CAT ▸ CYP19A1 ▸ PPARG ▸ CCNG1 ▸ SGK1 ▸ IL11 ▸
PDE3B ▸ PCNA ▸ NTRK2 ▸ PAK2 ▸ NANOG ▸ BMP6 ▸ TNFSF13B ▸
PLD1 ▸ PBK ▸ ABCB1 ▸ CD4 ▸ FGF1 ▸ ADORA3 ▸ CCND2 ▸
FGF3 ▸ ERBB2 ▸ CAV2 ▸ CALM3 ▸ CAV1 ▸ F2RL1 ▸ RBBP7 ▸
FGF4 ▸ TPO ▸ CXCL9 ▸ PLA2G4A ▸ RLN1 ▸ RBBP4 ▸ WNT4 ▸
FGF7 ▸ GPR15 ▸ FGF5 ▸ RNF19A ▸ EGR1 ▸ HDAC3 ▸ PIK3CG ▸
GAB2 ▸ EHMT1 ▸ AR ▸ FGF16 ▸ IL1A ▸ SMAD7 ▸ PAK1 ▸
STAT6 ▸ SPP1 ▸ FGF11 ▸ BPNT1 ▸ ATP5O ▸ SMAD9 ▸ FGF20 ▸
SMAD3 ▸ BAD ▸ TAT ▸ FGF8 ▸ SGK3 ▸ PDK1 ▸ IL24 ▸
SHC1 ▸ RLN2 ▸ PLD6 ▸ ITGB1 ▸ HSPB1 ▸ CAV3 ▸ MYC ▸
FGF18 ▸ KIT ▸ FGF12 ▸ BRAF ▸ FGF19 ▸ GSK3A ▸ CTLA4 ▸
AKT1S1 ▸ FGF10 ▸ NPY4R ▸ GPR20 ▸ IRS4 ▸ CDC23 ▸ CDC16 ▸
GPR116 ▸ GPR149 ▸ PAK3 ▸ CORO2A ▸ IL16 ▸ NOTCH1 ▸ AQP3 ▸
GAPDH ▸ GPR45 ▸ IL6ST ▸ GPR35 ▸ ARSK ▸ GPR25 ▸ IFNB1 ▸
CD14 ▸ IL15 ▸ IL27 ▸ CHKA ▸ GPR123 ▸ GPR17 ▸ MT3 ▸
PTTG1 ▸ FOXP3 ▸ PREX1 ▸ GPR182 ▸ SMN1 ▸ PAK7 ▸ GPR21 ▸
CCK ▸ GPR119 ▸ GPR107 ▸ GPR183 ▸ CX3CL1 ▸ GPR142 ▸ IL9 ▸
GPS2 ▸ BRCA1 ▸ IL34 ▸ PKD3 ▸ RPL17 ▸ GPR75 ▸ BMP7 ▸
HBEGF ▸ GPR139 ▸ GPR135 ▸ NTRK3 ▸ TBL1XR1 ▸ CALM1 ▸ BMP3 ▸
SNAI2 ▸ GPR173 ▸ MAP3K5 ▸ CSF2 ▸ WNT6 ▸ BIRC2 ▸ C1orf228 ▸
CDC27 ▸ SLPI ▸ BMP1 ▸ GPR156 ▸ PKD2 ▸ ANG ▸ GRP ▸
GPR151 ▸ GPR33 ▸ CDC6 ▸ IKBKB ▸ GPR126 ▸ WNT2 ▸ GPR64 ▸
ICOS ▸ PKD1 ▸ GPR62 ▸ GPR88 ▸ MUC8 ▸ ITIH4 ▸ SST ▸
GPR150 ▸ GPR83 ▸ CD19 ▸ SLC9A1 ▸ GPR68 ▸ GPR18 ▸ GPR61 ▸
PLEK ▸ CEBPB ▸ GPR42 ▸ TGFB3 ▸ NTF3 ▸ WNT16 ▸ PRDX2 ▸
GPR146 ▸ GPR108 ▸ GPR34 ▸ GPR114 ▸ CCL2 ▸ PTH ▸ GPR179 ▸
IL31 ▸ GPR36 ▸ GPR115 ▸ IL19 ▸ RBL2 ▸ GPR97 ▸ NFE2L2 ▸
TYR ▸ GPR26 ▸ GPR133 ▸ MOK ▸ GPR143 ▸ NM ▸ BMP4 ▸
PAK6 ▸ PRKCZ ▸ CSE ▸ LDLR ▸ CDK5 ▸ GPR152 ▸ GPR78 ▸
LTB ▸ PAK4 ▸ NCOR1 ▸ HMGB1 ▸ GPR39 ▸ GPR101 ▸ GPR3 ▸
GPR85 ▸ NCF1 ▸ ADAM12 ▸ GPR155 ▸ CDC20 ▸ GPR176 ▸ MAP3K7 ▸
BMP5 ▸ WNT3 ▸ IL21 ▸ IRF1 ▸ GPR79 ▸ MUC1 ▸ GPR111 ▸
MYCN ▸ CPOX ▸ CDC34 ▸ GPR141 ▸ ITGB4 ▸ RAE1 ▸ IL1RN ▸
GPR19 ▸ GPR65 ▸ GPR160 ▸ GPR32 ▸ GTPBP1 ▸ GPR171 ▸ GPR6 ▸
MSC ▸ SOCS3 ▸ FGR ▸ LIF ▸ GPR82 ▸ GPR56 ▸ GPR112 ▸
UVRAG ▸ GPR124 ▸ GPR84 ▸ CD86 ▸ ARAF ▸ GPR98 ▸ CCDC88A ▸
IGFBP3 ▸ DAB1 ▸ BSG ▸ GPR52 ▸ CXCL10 ▸ GPR55 ▸ ABL1 ▸
IL37 ▸ ADRBK1 ▸ AGTR2 ▸ CDC7 ▸ PLAT ▸ RHEB ▸ DAB2IP ▸
PTGES ▸ ITGA5 ▸ IL26 ▸ GPR144 ▸ MDM2 ▸ TBL1X ▸ PSEN1 ▸
LYN ▸ GPR137 ▸ GPR148 ▸ GPR110 ▸ GPR128 ▸ WNT11 ▸ GPR153 ▸
PDX1 ▸ GPER1 ▸ GPR1 ▸ CHUK ▸ GPR31 ▸ GPR87 ▸ TSC2 ▸
ITGA6 ▸ WNT1 ▸ CDC123 ▸ BMP10 ▸ GPR12 ▸ GPR161 ▸ CDH5 ▸
IL20 ▸ CDC26 ▸ GPR174 ▸ GPR4 ▸ GPR158 ▸ CD2 ▸ BMP15 ▸
IL22 ▸ SKP2 ▸ NRG1 ▸ IL33 ▸ TFRC ▸ ERBB4 ▸ CDC40 ▸
CALM2 ▸ GPR162 ▸ GPR180 ▸ GPR37 ▸ CDC37 ▸ GPR132 ▸ TRNAE1 ▸
PGP ▸ CDC45 ▸ NFAT5 ▸ CEBPA ▸ GPR27 ▸ GNE ▸ E2F1 ▸
MYOG ▸ CD38 ▸ NCF4 ▸ GPR50 ▸ GDF15 ▸ GPR157 ▸ GPR113 ▸
GPR63 ▸ IL25 ▸ VEGFC ▸ SIRT1 ▸ GPR22 ▸ GPR125 ▸ FGFR2 ▸
UCN ▸ DDIT3 ▸ PGK1 ▸ EDG1 ▸ MYO1C ▸ FRS2 ▸ RPSA ▸
ADAR ▸ ACTBL2 ▸ ITIH1 ▸ MOV10 ▸ NPHS2 ▸ HSP90AB1 ▸ HIST1H2AC ▸
MIF ▸ DGKZ ▸ YWHAH ▸ RPL23 ▸ RPS18 ▸ GNG4 ▸ GNG7 ▸
GNG13 ▸ RPS4X ▸ SHC3 ▸ HNRNPUL1 ▸ TRAT1 ▸ DNAJA1 ▸ SLC25A31 ▸
PIK3R2 ▸ TRB@ ▸ PIP5K1A ▸ GNG11 ▸ TUBB ▸ HIST1H2BO ▸ MRPS18B ▸
IGHE ▸ RBMX ▸ MATR3 ▸ FTL ▸ ACTG2 ▸ MRPS28 ▸ HIST1H2BN ▸
HLA-B ▸ IL23A ▸ XRN2 ▸ PABPN1 ▸ IGLC2 ▸ YWHAZ ▸ SEMG2 ▸
DLG1 ▸ ERH ▸ INS-IGF2 ▸ PIK3R3 ▸ PPP1CC ▸ ATPIF1 ▸ PDGFRA ▸
RPS5 ▸ EFNA1 ▸ PCBP3 ▸ SYNJ2 ▸ NGFB ▸ HLA-DRB1 ▸ NBPF8 ▸
PIP4K2A ▸ PCID2 ▸ IL2RB ▸ CCT5 ▸ HIST1H2AJ ▸ PDPK1 ▸ FGFR1OP2 ▸
HIST2H2AA4 ▸ MRPS27 ▸ PLCZ1 ▸ NPM1 ▸ SLC25A3 ▸ TREM2 ▸ RPL22 ▸
TRA@ ▸ SYNJ1 ▸ UFD1L ▸ MRPS25 ▸ FIGF ▸ PGAM2 ▸ IGHG2 ▸
FGFR1OP ▸ PABPC4 ▸ GNGT2 ▸ CNTRL ▸ MRPS22 ▸ GNB1 ▸ GNA15 ▸
CSF1R ▸ IL5RA ▸ WDR6 ▸ LAT2 ▸ RPLP1 ▸ GFRA1 ▸ POTEKP ▸
FCGR3A ▸ CTNNA1 ▸ HIST1H2AG ▸ GABRB1 ▸ FGB ▸ INPP5E ▸ GNB2 ▸
FUS ▸ HNRNPH2 ▸ SPTA1 ▸ INPP5B ▸ RPS12 ▸ SH3KBP1 ▸ OCRL ▸
HIST1H2BJ ▸ PAICS ▸ GNAI3 ▸ CRKL ▸ EPHB4 ▸ GHR ▸ IGHG1 ▸
SHANK3 ▸ SSR1 ▸ LGALS3BP ▸ RPS2 ▸ CPSF1 ▸ CUX1 ▸ KIRREL ▸
HIST1H2AE ▸ IFNGR1 ▸ FES ▸ HIST1H2BM ▸ MRAS ▸ RPS24 ▸ SNRPF ▸
HNRNPA0 ▸ TRIM21 ▸ NR3C1 ▸ AIFM1 ▸ MYL6 ▸ IGLC3 ▸ PPP1CB ▸
TIAM2 ▸ DDX5 ▸ HLA-DRA ▸ PRKCI ▸ CBLC ▸ GNG8 ▸ PLCD3 ▸
TUBA1A ▸ MARCKS ▸ ZMYM2 ▸ HIST1H1A ▸ HNRNPA1 ▸ KL ▸ CBLB ▸
PLCE1 ▸ PGAM1 ▸ HIST3H2A ▸ HRNR ▸ GNAI1 ▸ CD3Z ▸ PIK3R5 ▸
PIP5K1B ▸ YWHAQ ▸ ENO1 ▸ TPI1 ▸ KLRK1 ▸ IGKC ▸ PTBP1 ▸
HIST1H1T ▸ KHDRBS1 ▸ PTPN1 ▸ MRPS34 ▸ ATP5B ▸ DHX30 ▸ UBC ▸
TUBA4A ▸ KLRC2 ▸ YBX3 ▸ HLA-A ▸ LRPPRC ▸ WDR5 ▸ MYH14 ▸
F11R ▸ IL1R1 ▸ VEGF ▸ EEF1A1 ▸ YES1 ▸ APLP2 ▸ CALR ▸
ATP1A3 ▸ VAV3 ▸ CSF2RA ▸ IL23R ▸ PLCB4 ▸ VLDLR ▸ INSRR ▸
HNRNPR ▸ HLA-E ▸ NEDD9 ▸ HNRNPU ▸ KLB ▸ EEF1A2 ▸ IGF2BP3 ▸
AMBP ▸ ITGB3 ▸ PCBP1 ▸ ENY2 ▸ DHX15 ▸ HIST1H2AD ▸ STAU1 ▸
HNRNPDL ▸ RTCB ▸ HNRNPF ▸ HNRNPC ▸ ITGB2 ▸ ARHGEF1 ▸ PTMA ▸
UPF1 ▸ EEF2 ▸ PIK3R6 ▸ EFNB2 ▸ SGK2 ▸ AMPH ▸ GNB3 ▸
CSF2RB ▸ ACTA2 ▸ ALYREF ▸ GH1 ▸ TUBA1C ▸ ZAP70 ▸ PTCD3 ▸
EPS8 ▸ H2AFJ ▸ RUVBL1 ▸ DDX17 ▸ IGF2BP1 ▸ MRPS14 ▸ FGG ▸
IGKV1-5 ▸ IGKV4-1 ▸ VAV2 ▸ NKRF ▸ PGR ▸ SH2D2A ▸ PIK3R4 ▸
ATXN2L ▸ CCAR2 ▸ STAT5B ▸ SEMG1 ▸ YWHAG ▸ GNB4 ▸ IGHG4 ▸
GNAQ ▸ PLCB1 ▸ IGLC6 ▸ MASP1 ▸ MS4A2 ▸ PLCB3 ▸ PIP5K1C ▸
GNG12 ▸ H2BFS ▸ DHX9 ▸ IL1RAP ▸ PIK3C2G ▸ IGLC7 ▸ GNGT1 ▸
MAP2K2 ▸ GRIN2B ▸ SLC25A4 ▸ S100A10 ▸ EEF1A1P5 ▸ GNG3 ▸ HIST3H2BB ▸
HIST1H2BD ▸ HNRNPH3 ▸ NPHS1 ▸ PPIA ▸ MDH2 ▸ IGLC1 ▸ ILF2 ▸
SLC9A3R1 ▸ HNRNPL ▸ KLRD1 ▸ GNA14 ▸ IL3RA ▸ HNRNPA2B1 ▸ GSN ▸
EIF5AL1 ▸ HNRNPA3 ▸ AP1M2 ▸ HNRNPK ▸ ANGPT1 ▸ RUVBL2 ▸ BASP1 ▸
GNG5 ▸ RRAS2 ▸ CKB ▸ MYH9 ▸ FLT1 ▸ PCBP2 ▸ JUP ▸
ELAVL1 ▸ DNAJB11 ▸ FCER1G ▸ RALY ▸ NRAS ▸ PLCD4 ▸ RPS3 ▸
RPLP0 ▸ EIF2AK1 ▸ PDE4D ▸ GNAO1 ▸ HIST2H2AC ▸ ADAP1 ▸ MYH10 ▸
EPHB1 ▸ RPLP0P6 ▸ DDX3Y ▸ TYROBP ▸ LAT ▸ FLNB ▸ GNA11 ▸
CANX ▸ HIST1H2BL ▸ HCST ▸ IGF2BP2 ▸ RASD2 ▸ SQSTM1 ▸ VARS2 ▸
IL4R ▸ PABPC1 ▸ ITK ▸ EIF5A2 ▸ BCAR1 ▸ TIMM50 ▸ ITGAV ▸
PLCD1 ▸ SNRPD3 ▸ YWHAE ▸ B2M ▸ DDX3X ▸ HNRNPH1 ▸ LDHB ▸
CD247 ▸ HIST1H2BK ▸ RASGRP3 ▸ PIP4K2C ▸ ANXA2 ▸ SOS1 ▸ PON2 ▸
DNM1L ▸ Il7r ▸ RHOG ▸ MRPS17 ▸ PIK3C2B ▸ HNRNPD ▸ PHLDA1 ▸
PRKRA ▸ SYNCRIP ▸ SLC25A5 ▸ GNG10 ▸ ABI1 ▸ ALDOA ▸ HIST2H2BE ▸
GNAI2 ▸ PIK3AP1 ▸ ATP1A1 ▸ HIST1H2AB ▸ PLCB2 ▸ NEFH ▸ MRPS26 ▸
EPB41L1 ▸ FCGR3B ▸ FLT3 ▸ RPL28 ▸ FCGR1A ▸ TXK ▸ UBTF ▸
C14orf166 ▸ HIST2H2AA3 ▸ GNG2 ▸ PIK3C2A ▸ FCER1A ▸ IL12RB1 ▸ SMO ▸
TUBB4B ▸ DNAJB6 ▸ APPL1 ▸ TRIM24 ▸ CD80 ▸ SHC2 ▸ PPP1CA ▸
HIST1H2AH ▸ ATR ▸ HIST2H2BF ▸ FBL ▸ RPS20 ▸ UNC5B ▸ RPS10 ▸
TEK ▸ HNRNPAB ▸ PGAM4 ▸ HIST1H2BB ▸ IL2RG ▸ MRPL12 ▸ PRDX6 ▸
MRPS23 ▸ PGF ▸ HIST1H4A ▸ RPS11 ▸ ILF3 ▸ GNB5 ▸ FGA ▸
EIF5A ▸ IGHG3 ▸ HIST1H2BH ▸
Data information
Please see the Gene Interactions Track Manual.