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HSPB1 — IL10
Text-mined interactions from Literome
De et al., J Immunol 2000
:
Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2, c-Jun N-terminal kinase, and p38 ), only p38 activation was sustained and required for
hsp27 induction of monocyte
IL-10 , while both ERK 1/2 and p38 activation were required for induction of TNF-alpha when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059 ... The failure of either PD98059 or anti-TNF-alpha Ab to substantially inhibit IL-10 induction implied that
hsp27 induces
IL-10 via activation of p38 signaling independently of TNF-alpha activation and may be predominantly an antiinflammatory monokine stimulus
Sheth et al., J Surg Res 2001
:
Hsp 27 does not
induce secretion of TNF-alpha,
IL-10 , or IL-12, whereas LPS does signal IL-12 and TNF-alpha secretion
Santell et al., Biochem J 1992
:
Down-regulation of protein kinase C-alpha by prolonged treatment with phorbol esters eliminated the ability of phorbol 12-myristate 13-acetate, dioctanoylglycerol, thrombin and histamine to phosphorylate HSP27 above background levels and deceased
interleukin-1 stimulated
HSP27 phosphorylation by 60 %
Rayner et al., Circ Res 2008
(Atherosclerosis) :
Furthermore, extracellular
HSP27 decreased acLDL induced release of the proinflammatory cytokine IL-1beta and
increased the release of the antiinflammatory cytokine
IL-10
Miller-Graziano et al., Novartis Found Symp 2008
:
HSP27 increased MO
IL10 and M-CSF production but subsequent increased Mac differentiation is n't responsible for depressed MO to iDC differentiation and function
Cuenda et al., FEBS Lett 1995
:
We now show that one of these compounds ( SB 203580 ) inhibits RK in vitro ( IC50 = 0.6 microM ), suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of
heat shock protein (HSP) 27 in
response to
interleukin-1 , cellular stresses and bacterial endotoxin in vivo