LOVD is intended for use primarily by physicians and other
professionals concerned with genetic disorders, by genetics researchers, and
by advanced students in science and medicine. While the LOVD database is
open to the public, users seeking information about a personal medical or
genetic condition are urged to consult with a qualified physician for
diagnosis and for answers to personal questions. Further, please be
sure to visit the LOVD web site for the very latest, as they are continually
LOVD databases are owned by their respective curators
and are not available for download or mirroring
by any third party without their permission. Batch queries on this track are only available via the
UCSC Beacon API (see below). See also the
LOVD web site
for a list of database installations and the respective curators.
This track shows the genomic positions of all public entries in public
installations of the Leiden Open Variation Database system (LOVD) and the effect of the
variant, if annotated.
Due to the copyright restrictions of the LOVD databases, UCSC is not allowed to
host any further information. To get details on a variant (bibliographic
reference, phenotype, disease, patient, etc.), follow the
"Link to LOVD" to the central server at Leiden, which will then redirect you
to the details page on the particular LOVD server reporting this variant.
Since Apr 2020, similar to the ClinVar track, the data is split into two subtracks, for variants
with a length of < 50 bp and >= 50 bp, respectively.
LOVD is a flexible, freely-available tool for gene-centered collection and
display of DNA variations. It is not a database itself, but rather a platform
where curators store and analyze data. While the LOVD team and the biggest LOVD
sites are run at the Leiden University Medical Center, LOVD installations and their
curators are spread over the whole world. Most LOVD databases report at least
some of their content back to Leiden to allow global cross-database search, which
is, among others, exported to this UCSC Genome Browser track every month.
A few LOVD databases are entirely missing from this track. Reasons include configuration issues and
intentionally blocked data search. During the last check in November 2019, the following databases
did not export any variants:
Curators who want to share data in their database so it is present in this track can find more
details in the LOVD FAQ.
The LOVD data is not available for download or for batch queries in the Table Browser.
However, it is available for programmatic access via the Global
Alliance Beacon API, a web service that accepts queries in the form
(genome, chromosome, position, allele) and returns "true" or "false" depending
on whether there is information about this allele in the database. For more details see our
To find all LOVD databases that contain variants of a given gene, you can get a list of databases by
constructing a url in the format geneSymbol.lovd.nl, for example,
tp53.lovd.nl. You can
then use the LOVD API to retrieve more detailed information from a particular database. See the
Display Conventions and Configuration
Genomic locations of LOVD variation entries are labeled with the gene symbol
and the description of the mutation according to Human Gene Variation Society
standards. For instance, the label AGRN:c.172G>A means that the cDNA of AGRN is
mutated from G to A at position 172.
Since October 2017, the functional effect for variants is shown on the details page, if annotated.
The possible values are:
LOVD does not use the term "pathogenic", please see the HGVS Terminology page for
All other information is shown on the respective LOVD variation page, accessible via the
"Link to LOVD" above.
The mappings displayed in this track were provided by LOVD.
Thanks to the LOVD team, Ivo Fokkema, Peter Taschner, Johan den Dunnen, and all LOVD curators who
gave permission to show their data.
Fokkema IF, Taschner PE, Schaafsma GC, Celli J, Laros JF, den Dunnen JT.
LOVD v.2.0: the next generation in gene variant databases.
Hum Mutat. 2011 May;32(5):557-63.