This track lists amino acid positions that are close to
certain Covid drug target protein binding sites; potentially relevant
for viral drug resistance. The protein products are the S, NSP3, and NSP5 proteins. The data is
derived from 3D Protein Data Bank (PDB) X-ray crystal structures and was imported from
Coronavirus3d.org, a project funded by NIAID, NIGMS and UCR. For more information, please
visit that site and look through the 9 protein-drug structures listed.
The display shows amino acids within 5 Angstroms of an inhibitor binding site on the
S, NSP3, and NSP5 proteins. The label of the annotations
is the number of GISAID sequences with at least one mutation
at this position as of March 3, 2022. Click or mouse-over
the mutations to show the full list of nucleotide changes and the
frequency of each.
You can see the original data
as tables on Coronavirus3d.org.
The data can be explored interactively at the Genome Browser with the
Table Browser or the
For automated analysis, the genome annotation is stored in
a bigBed file that can be downloaded from
the download server
or the API.
Please refer to our
mailing list archives for questions, or our
Data Access FAQ
for more information.
Thanks to Anna Niewiadomska from
the BV-BRC team at the J. Craig Venter Institute for finding the dataset and testing
the track. Thanks to the Godzik Lab for making available the data in .tsv format
on the coronavirus3d.org website.