the "Catalogue Of Somatic Mutations In Cancer," is an online database of somatic mutations found in
human cancer. Focused exclusively on non-inherited acquired mutations, COSMIC combines information
from a range of sources, curating the described relationships between cancer phenotypes and gene
(and genomic) mutations. These data are then made available in a number of ways including here in the
UCSC genome browser, on the COSMIC website with custom analytical tools, or via the
COSMIC sftp server.
Publications using COSMIC as a data source may cite our reference below.
The data in COSMIC are curated from a number of high-quality sources and combined into a single
resource. The sources include:
Information on known cancer genes, selected from the
Cancer Gene Census is curated manually to maximize its descriptive content.
The data was downloaded from the COSMIC sftp server. It was first converted to a bed file using
the UCSC utility cosmicToBed, then converted into a bigBed file using the UCSC utility bedToBigBed.
The bigBed file is used to generate the track.
- Dense - Indicate the positions where COSMIC mutations have been annotated in a single horizontal
- Squish - Indicate each mutation, in vertical pileups where appropriate, while minimizing
screen space used.
- Pack - Indicate each mutation with COSMIC identifier (COSMnnnnn).
- Full - Show each mutation in detail, one per line, with COSM identifier (COSMnnnnn).
Due to licensed material, we do not allow downloads or Table Browser access for the bigBed data. The
raw data underlying this track can be explored and downloaded via the COSMIC
CosmicMutantExport.tsv.gz file was converted to a BED file using the
utility, and then converted into a bigBed file using the
bedToBigBed utility. You can
download these tools from the
For further information on COSMIC, or for help with the information provided, please contact
Forbes SA, Beare D, Boutselakis H, Bamford S, Bindal N, Tate J, Cole CG, Ward S, Dawson E, Ponting L
COSMIC: somatic cancer genetics at high-resolution.
Nucleic Acids Res. 2017 Jan 4;45(D1):D777-D783.
PMID: 27899578; PMC: PMC5210583