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IL22 — TNF
Text-mined interactions from Literome
De Caterina et al., Am J Clin Nutr 2000
(Arteriosclerosis) :
Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ),
interleukin 6 (IL-6), and IL-8 in
response to IL-1, IL-4,
tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Ghigo et al., Infect Immun 2001
(Endocarditis, Bacterial...) :
First,
interleukin-10 suppressed C. burnetii stimulated production of
TNF
Werth et al., J Invest Dermatol 2003
:
Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that
interleukin-12 might also
affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous
interleukin-12 totally
blocked ultraviolet-B induced
tumor necrosis factor alpha production ... Thus,
interleukin-12 strongly
inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Lin et al., Crit Care Med 2003
(Hyperoxia) :
Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia
+ tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha,
interleukin-1 beta, and GRO/CINC-1 release
Jana et al., J Neurochem 2003
:
Induction of
tumor necrosis factor-alpha (TNF-alpha) by
interleukin-12 p40 monomer and homodimer in microglia and macrophages
Maeda et al., J Invest Dermatol 2003
:
Among T helper 1 cytokines,
interleukin-4 mediated suppression of
tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Tada et al., Hokkaido Igaku Zasshi 1992
(Brain Neoplasms...) :
TNF at a low dose ( 10 U/ml )
stimulated production of prostaglandin E2, Mn-superoxide dismutase,
interleukin (IL)-6 and IL-8 by glioblastoma cells
Ichiyama et al., Inflamm Res 2004
:
Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation,
interleukin-6 (IL-6) production, and E-selectin expression
induced by
TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively
Cheon et al., J Rheumatol 2004
(Arthritis, Rheumatoid...) :
When RA FLS are stimulated with
interleukin 1 or
tumor necrosis factor-a , WISP3 mRNA is significantly
increased
Desmet et al., Biochem Pharmacol 2005
:
On the contrary, both RSG and TRO significantly potentiated
TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor,
interleukin (IL)-6 and/or IL-8 in these cells
Brand et al., Am J Physiol Gastrointest Liver Physiol 2006
(Crohn Disease...) :
IL-22 significantly
increased cell proliferation ( P = 0.002 ) and phosphatidylinsitol 3-kinase dependent IEC cell migration ( P < 0.00001 ) as well as mRNA expression of
TNF-alpha , IL-8, and human beta-defensin-2
Van Damme et al., J Invest Dermatol 1990
:
This study focuses on interferon-beta (IFN-beta),
interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in
response to interleukin-1 (IL-1) and
tumor necrosis factor-alpha (TNF-alpha)
Brand et al., Am J Physiol Gastrointest Liver Physiol 2007
(Disease Models, Animal...) :
IL-22 increased the mRNA expression of suppressor of cytokine signaling (SOCS)-3 and the proinflammatory cytokines IL-6, IL-8, and
TNF-alpha
Choi et al., FEMS Immunol Med Microbiol 2007
(Candidiasis) :
CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving
tumor necrosis factor-alpha dependent
interleukin-12 induction
Shembade et al., J Virol 2007
:
Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal
tumor necrosis factor- and
interleukin-1 mediated NF-kappaB
activation
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced
activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Tyagi et al., Mol Cell Endocrinol 2010
:
In addition, like 17beta-estradiol, presence of medicarpin inhibited
TNFalpha induced upregulation of
interleukin-1 , and -6 mRNA levels in osteoblasts
Gutteberg et al., APMIS 1991
(Sepsis) :
Using a whole blood in vitro model, we have investigated the
effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and
tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF),
interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Elias et al., Chest 1990
(Pneumonia...) :
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the
effects of recombinant interleukin-1,
tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production,
interleukin-1-beta production, and interleukin-6 production
Zenewicz et al., Int Immunol 2011
(Communicable Diseases) :
T ( h ) 22 cells produce
IL-22 in
response to IL-6 and
tumor necrosis factor a (TNF-a) , particularly in the skin, whereas ?d T cells produce IL-22 in response to IL-23, particularly in the lung
Chan et al., Int J Oncol 1997
:
Involvement of
interleukin-1 in the differentiation inducing activity of
tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
Carlo et al., J Pediatr 2011
(Cerebral Palsy...) :
The analyses were focused on 5 cytokines (
interleukin [ IL] 1ß ; IL-8 ;
tumor necrosis factor-a ;
regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Takeda et al., Int Immunopharmacol 2011
(Orthomyxoviridae Infections) :
On day 2,
tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a,
interleukin-12 , and interferon-? productions were
augmented and natural killer ( NK ) cell activity was significantly elevated
Ma et al., J Pharmacol Sci 2012
:
We also demonstrated that pretreatment of cells with this compound prevented
TNF-a induced expression of NF-?B target genes, such as interleukin 6,
interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Villacres et al., J Infect Dis 2012
(HIV Infections...) :
Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß),
interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and
tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Gunaydın et al., J Pediatr Surg 2012
(Acute Lung Injury...) :
Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and
tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and
inhibited the expressions of tumor necrosis factor a and
interleukin-1ß
Elias et al., Am J Respir Cell Mol Biol 1990
:
We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in
response to recombinant
interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant
tumor necrosis factor ( rTNF )
Tsukamoto et al., Inflamm Bowel Dis 2013
:
: Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß
induced TNF-a
shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Zindl et al., Proc Natl Acad Sci U S A 2013
(Colitis) :
Freshly isolated colon infiltrating neutrophils produced IL-22 contingent upon IL-23 signaling, and
IL-22 production was
augmented by
TNF-a
Gowen et al., Endocrinology 1990
:
Human osteoblast cultures derived as out-growths from trabecular bone released
tumor necrosis factor ( TNF alpha ) upon
stimulation of the cells with human recombinant
interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Palladino et al., Ciba Found Symp 1987
(Neoplasms, Experimental) :
Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of
TNF-alpha or TNF-beta may
involve the following biological activities : the induction of
interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Bachwich et al., Biochem Biophys Res Commun 1986
:
Tumor necrosis factor stimulates
interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the
effect of
tumor necrosis factor on the release of
interleukin-1 and PGE2 from murine resident peritoneal macrophages ...
Tumor necrosis factor causes an increase in the production of
interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Hoffman et al., Lymphokine Res 1986
:
The
effects of
tumor necrosis factor on the production of
interleukin-1 by macrophages
Le et al., J Immunol 1987
:
Induction of membrane associated
interleukin 1 by
tumor necrosis factor in human fibroblasts
Männel et al., Rev Infect Dis 1987
:
No
TNF induced production of
interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Libby et al., Am J Pathol 1986
:
Endotoxin and
tumor necrosis factor induce
interleukin-1 gene expression in adult human vascular endothelial cells
Ferreira et al., Drugs 1993
(Hyperalgesia...) :
The release of
tumour necrosis factor-alpha (TNF-alpha) initiates the release of
interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Benveniste et al., Int J Dev Neurosci 1995
:
In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ),
interleukin-10 (IL-10) and interleukin-6 (IL-6)
inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Tsuji et al., Am J Pathol 1995
(Granuloma...) :
Thus,
interleukin-1 alpha and inducible nitric oxide synthase were
induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas
tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Aggarwal et al., Exp Cell Res 1995
:
Diminished responsiveness of senescent normal human fibroblasts to
TNF dependent proliferation and
interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Judd et al., Am J Physiol 1995
:
ZG cells released IL-6 and
TNF , and this release was
stimulated by lipopolysaccharide,
interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Seatter et al., Arch Surg 1994
(Disease Models, Animal) :
Tumor necrosis factor and
interleukin-1 regulation by lipopolysaccharide pretreatment
Blasi et al., Infect Immun 1994
:
Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances
TNF and
induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Becher et al., J Clin Invest 1996
:
Soluble
tumor necrosis factor receptor
inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Yamamoto et al., Eur J Pharmacol 1996
(Disseminated Intravascular Coagulation) :
Plasma interleukin-1 and
TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h )
inhibited the increased plasma
interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Ortiz-Arduan et al., Am J Physiol 1996
(Endotoxemia) :
Lipopolysaccharides (LPS),
interleukin-1 beta, interferon-gamma (IFN-gamma), and
TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Klegeris et al., Brain Res 1997
(Alzheimer Disease) :
First, it was shown that THP-1 cells could be
induced to secrete significant amounts of
TNF-alpha by
interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Li et al., Eur J Pharmacol 1998
(Multiple Sclerosis) :
Production of
tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of
interleukin-1 increased
Bryson et al., Arch Biochem Biophys 1998
:
It potently inhibited
interleukin 1- and
tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Fiedler et al., Am J Respir Cell Mol Biol 1998
:
The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit
TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation,
interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by interleukin-10, transforming growth factor-beta,
tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra