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NFKB1 — PRKCA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(modification, activates)
Sakurai et al., J Biol Chem 1999, Ducut Sigala et al., Science 2004, Brockman et al., Mol Cell Biol 1995, Brown et al., Science 1995, Zhong et al., Cell 1997, Zhong et al., Mol Cell 1998
Evidence: assay, physical interaction
Text-mined interactions from Literome
Yang et al., J Immunol 2001
:
The involvement of a conventional PKC isoform was confirmed by the finding that expression of PKCalpha enhanced the effect of Galpha(16), and a dominant negative
PKCalpha partially
blocked Galpha(16) mediated
NF-kappaB activation
Lee et al., Cancer Chemother Pharmacol 2004
:
For experimentally induced tumor promotion, we investigated whether the SNL glycoprotein was able to regulate the activity of
protein kinase C alpha (PKCalpha) , the DNA binding
activation of
nuclear factor-kappa B (NF-kappaB) , the activity of NF-kappaB protein, and the production of nitric oxide ( NO ) in HCT-116 cells stimulated with 12-O-tetradecanoylphorbol 13-acetate ( TPA ) using electrophoretic mobility shift assays ( EMSA ), Western blot analysis, and NO assays
Gopee et al., Cell Biol Toxicol 2004
:
The aim of current study was to investigate the
effect of
PKCalpha activation by FB1 on
NF-kappaB activation and subsequently on TNFalpha gene expression and caspase 3 induction in LLC-PK1 cells ... In summary, we hereby demonstrate that the FB1 activation of
NF-kappaB and sequential induction of TNFalpha expression resulting in the subsequent increase in caspase 3 activity are all
dependent on
PKCalpha stimulation in LLC-PK1 cells
Asehnoune et al., Cell Signal 2005
:
PKCalpha/beta can
regulate NF-kappaB dependent transcription in neutrophils both by enhancing nuclear translocation of
NF-kappaB and also by stimulating phosphorylation of the p65 subunit
Zhu et al., J Steroid Biochem Mol Biol 2004
(MAP Kinase Signaling System) :
This effect may be associated with the decreased expression of p27, the increased expression of
PKC-alpha , and the
activation of
NF-kappaB
Rouquette-Jazdanian et al., J Immunol 2005
:
Combined all together : raft modification in terms of lipids, ceramide production,
protein kinase Calpha inhibition , and
NF-kappaB activation lead to CD4+ T cell inhibition
Bolick et al., Arterioscler Thromb Vasc Biol 2006
:
Inhibition of rhoA and
PKCalpha significantly
reduced NF-kappaB activation, ICAM-1 induction, and monocyte adhesion to aorta
Paria et al., J Biol Chem 2006
:
Inhibition of store Ca ( 2+ ) depletion, buffering of intracellular Ca ( 2+ ), or down-regulation of
protein kinase Calpha downstream of Ca ( 2+ ) influx all
blocked thrombin induced
NF-kappaB activation and the resultant TRPC1 expression in endothelial cells
Banzi et al., Biochem Biophys Res Commun 2006
:
Polycystin-1 promotes
PKCalpha mediated
NF-kappaB activation in kidney cells ... CTT dependent
NF-kappaB promoter activation was
mediated by
PKCalpha because it was blocked by its specific inhibitor Ro-320432 ... These data reveal, therefore, a novel pathway by which polycystin-1 activates a
PKCalpha mediated
NF-kappaB signalling and cell survival
Liao et al., Neurochem Int 2007
:
The inductive action of manganese was accompanied by generation of oxidative stress,
activation of mitogen activated protein kinases ( MAPKs ), AKT, and protein kinase C-alpha
(PKC-alpha) , and increased
NF-kappaB and AP-1 DNA binding activities
Horovitz-Fried et al., Biochem Biophys Res Commun 2007
:
Thus,
PKCalpha regulates insulin induced PKCdelta expression levels and this regulation
involves activation of SP-1 and
NFkappaB
Chun et al., J Pharm Pharmacol 2007
:
Furthermore, ergolide mediated
protein kinase Calpha (PKCalpha) inhibition is
involved in reduction of
NF-kappaB inhibition, as demonstrated by the observation that dominant negative PKCalpha, but not p44/42 MAPK and p38 MAPK, inhibits TPA stimulated reporter gene expression
Mahanivong et al., Oncogene 2008
(Neoplasm Invasiveness...) :
Although constitutively active mutants of PKCalpha ( a cPKC ), PKCtheta ( a novel PKC ( nPKC ) ) and PKCzeta ( an atypical PKC ( aPKC ) ) were all able to activate NF-kappaB and upregulate uPA expression, only dominant negative
PKCalpha mutant
attenuated LPA induced
NF-kappaB activation and uPA upregulation
Kanetaka et al., Exp Cell Res 2008
:
Together, these results demonstrate that IFN-alpha causes a transient upregulation of c-FLIP expression, at least through
PKCalpha mediated activation of
NF-kappaB
Langlet et al., Eur J Immunol 2010
:
Dominant negative
PKC-alpha inhibited
NF-kappaB reporter activity mediated by overexpression of MyD88 but not TRIF
Chao et al., J Agric Food Chem 2010
:
By means of confocal microscope analysis we demonstrated that phosphorylation and membrane translocation of
protein kinase C-alpha , as well as
NF-kappaB activation , were inhibited by honokiol in LPS stimulated macrophages
Mut et al., Turk Neurosurg 2010
(Glioblastoma) :
The
activation of
NF-kappaB by
PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate ( PMA )