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FGF10 — FGF8

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF8 → FGF10 (reaction) Carpenter et al., Exp Cell Res 1999, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Byron et al., Cancer Res 2008, Schüller et al., Biochem J 2008, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998

Text-mined interactions from Literome

Lizarraga et al., Dev Genet 1999 : A paracrine signaling loop model has been proposed whereby FGF10 expressed by limb mesoderm signals via ectodermally restricted FGFR2b to regulate FGF8 expression by the apical ectoderm ; in turn, FGF8 signals via mesodermally restricted FGFR2c to maintain FGF10 expression [ Ohuchi H, et al. 1997
Ohuchi et al., Dev Growth Differ 1999 : FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm, independent of its dorsoventral specification ... A secreted molecule fibroblast growth factor (FGF)10 is involved in inducing Fgf8 expression in the prospective AER and mutual interaction between mesenchymal FGF10 and FGF8 in the AER is essential for limb outgrowth ... It was found that FGF10 is sufficient to induce Fgf8 expression in the ectoderm of the foil inserted limb bud, concomitantly with R-fng and En1 expression
Kettunen et al., Dev Dyn 2000 : In vitro analyses showed that expression of Fgf-3 and Fgf-10 in the dental mesenchyme was dependent on dental epithelium and that epithelially expressed FGFs, FGF-4 and -8 induced Fgf-3 but not Fgf-10 expression in the isolated dental mesenchyme
Kawakami et al., Cell 2001 : Finally, we also show that the induction of Fgf-8 in the limb ectoderm by FGF-10 is mediated by the induction of Wnt-3a
Acosta et al., Am J Physiol Lung Cell Mol Physiol 2001 : Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen treated and control lungs but also substantially rescues nitrofen induced lung hypoplasia in culture
Liu et al., Development 2002 (Limb Deformities, Congenital) : In this system, FGF10 but not FGF8 protein injected into the mutant distal tip mesenchyme restores Fgf8 expression in the AER
Papadopoulou et al., Diabetes 2005 : We have earlier shown that the fibroblast growth factor ( FGF ) receptor 2 is expressed in pancreatic progenitor cells and that FGF10 , the high-affinity ligand of the FGF receptor 2 isoform FGF receptor 2b, promotes expansion of pancreatic progenitors
Saitsu et al., Mech Dev 2006 (Heart Defects, Congenital) : Moreover, over-expression of Fgf15 resulted in up-regulation of Fgf8 expression in the isthmus/r1
Zelarayan et al., Dev Biol 2007 : In the mouse, hindbrain derived FGF10 ectopically induces FGF8 and rescues otic vesicle formation in Fgf3 and Fgf10 homozygous double mutants
Katayama et al., Int J Oncol 2010 (Prostatic Neoplasms) : Overall, bicalutamide inhibits the cyclin A expression possibly by inhibiting FGF-8 mRNA expression and FGF-8 protein secretion but not by inhibiting FGF receptor ( FGFR ) signalling in androgen dependent cell lines, and by other mechanisms in androgen independent cell lines
Xu et al., Development 1998 : Consistent with this defect, the expression of Fgf8 , an apical ectodermal factor, is absent in the mutant presumptive limb ectoderm, and the expression of Fgf10 , a mesenchymally expressed limb bud initiator, is down regulated in the underlying mesoderm