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CCND1 — RHOA
Text-mined interactions from Literome
Bauerfeld et al., Am J Physiol Lung Cell Mol Physiol 2001
:
Cdc42, but not
RhoA ,
regulates cyclin D1 expression in bovine tracheal myocytes ... Here, we examined the
regulation of
cyclin D1 expression by Cdc42 and
RhoA ... Furthermore, dominant negative Cdc42, but not
RhoA ,
attenuated platelet derived growth factor mediated activation of the
cyclin D1 promoter
Liberto et al., Oncogene 2002
:
In addition, C3 blocked EGF stimulated cyclin D1 promoter activity whereas
V14RhoA induced the
cyclin D1 promoter and cooperated with V12Ras in cyclin D1 induction
Wang et al., J Biol Chem 2004
:
These effects are accompanied by activation of
cyclin D1 transcription and
repression of the collagen X promoter by
RhoA ... Dominant negative
RhoA also
inhibits induction of the
cyclin D1 promoter by parathyroid hormone related peptide
Debidda et al., J Biol Chem 2005
(Inflammation) :
STAT3 was required for the
RhoA induced NF-kappaB and
cyclin D1 transcription and was involved in NF-kappaB nuclear translocation
Watts et al., Respir Res 2006
(Pulmonary Fibrosis) :
To further explore
RhoA regulation of
cyclin D1 in lung fibroblasts and associated cell cycle progression, an established Rho inhibitor, Simvastatin, was incorporated in our studies
Forti et al., Endocr Relat Cancer 2007
(Adrenal Cortex Neoplasms...) :
Vasopressin triggers senescence in K-ras transformed cells via
RhoA dependent downregulation of
cyclin D1
Weber et al., J Biol Chem 1997
:
Ras stimulated extracellular signal related kinase 1 and
RhoA activities coordinate platelet derived growth factor
induced G1 progression through the independent regulation of
cyclin D1 and p27 ... Overexpression of dominant negative forms of Ras or
RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation, but only dominant negative Ras
inhibited cyclin D1 protein expression