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IFNG — IRF1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Paludan et al., Scand J Immunol 1999
(Herpes Simplex) :
Neither IL-4 nor HSV-2 affected the IFN-gamma activated Jak-STAT ( Janus kinase-signal transducer and activator of transcription ) pathway or altered the levels of
IFN-gamma induced
interferon regulatory factor (IRF)-1 expression, which is STAT1 dependent and known to play a central role in IFN-gamma mediated gene induction
Kano et al., Biochem Biophys Res Commun 1999
:
Taken together,
IRF-1 mediates
IFN-gamma signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis ... Taken together,
IRF-1 mediates
IFN-gamma signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis
Ackermann et al., J Immunol 1999
:
Both
IFN-gamma and IL-4
increased expression of the inducible transcription factor
IFN regulatory factor-1 (IRF-1) , but levels of IRF-1 only weakly correlated with levels of pIgR mRNA, suggesting that additional transcription factors are required
Mori et al., J Cell Biochem 1999
:
Induction of transcription factor
interferon regulatory factor-1 by
interferon-gamma (IFN gamma) and tumor necrosis factor-alpha (TNF alpha) in FRTL-5 cells ... In the present study, we used FRTL-5 rat thyroid cells to examine the
effects of
IFN gamma and TNF alpha on gene expression of transcription factor
interferon regulatory factor-1 (IRF-1) , which is involved in mediating the effects of these cytokines in a number of cell types
Lee et al., FEBS Lett 1999
:
IFN-gamma induces the expression of many early response genes such as
interferon regulatory factor-1 (IRF-1) by activation of signal transducer and activator of transcription ( STAT ) factor proteins
Green et al., Leukemia 1999
(Chromosome Deletion...) :
Unexpectedly, all primary acute promyelocytic leukemia ( APL ) samples lacked IRF-1 protein and most exhibited accelerated exon skipping ; furthermore,
IRF-1 could not be
induced by
IFNgamma or all-trans retinoic acid ( ATRA ) which both induce IRF-1 in the NB4 APL cell line ... Unexpectedly, all primary acute promyelocytic leukemia ( APL ) samples lacked IRF-1 protein and most exhibited accelerated exon skipping ; furthermore,
IRF-1 could not be
induced by
IFNgamma or all-trans retinoic acid ( ATRA ) which both induce IRF-1 in the NB4 APL cell line
Saito et al., J Immunol 2000
:
Gel-shift assays revealed that
IFN-gamma induced
IFN regulatory factor-1 (IRF-1) binding to VIRE, but not that of IRF-2 or three components of ISGF3
Coccia et al., Int Immunol 2000
:
Accordingly, the
IFN-gamma induced binding activity of
IRF-1 to the ISRE sequence was reduced in cells pre treated with IL-4, while the binding activity of STAT-1 to the STAT binding element (SBE) within the same region of the iNOS promoter remained unaffected ... Although STAT-6 has no trans acting function on iNOS gene expression, it is able to inhibit the
IFN-gamma induced expression of
IRF-1
Momose et al., Biochim Biophys Acta 2000
:
Phorbol ester synergistically increases
interferon regulatory factor-1 and inducible nitric oxide synthase
induction in
interferon-gamma treated RAW 264.7 cells ... The synergistic effect of PMA on
IFN-gamma induced
IRF-1 binding activity was observed in macrophage cell line J774 cells as well as RAW 264.7 cells, but not in thioglycollate elicited peritoneal macrophages
O'Keefe et al., J Immunol 2001
:
As well,
IFN-gamma induced expression of
IRF-1 and its binding to the IRF element is inhibited
Suk et al., J Biol Chem 2001
(Necrosis...) :
IFNgamma induced STAT1 phosphorylation and
interferon regulatory factor 1 (IRF-1) expression
Blair et al., J Biol Chem 2002
:
Interferon regulatory factor-1 (IRF-1) , the activation of which is
induced by dsRNA, viral infection, and
IFN-gamma , regulates the expression of many antiviral proteins, including PKR, type I IFN, and iNOS ... Importantly, we show that dsRNA- or dsRNA +
IFN-gamma stimulated
IRF-1 expression by mouse islets and peritoneal macrophages is independent of PKR
Teng et al., Am J Physiol Cell Physiol 2002
:
Conversely,
IFN-gamma , but not IL-1 beta,
induced signal transducer and activator of transcription ( STAT ) 1 and
interferon regulatory factor (IRF)-1 binding
Jarosinski et al., J Neuroimmunol 2002
:
As expected, astrocytes from wild type ( IRF-1 ( +/+ ) ) mice showed a coordinate increase in both
IRF-1 and MHC class I gene expression in
response to
IFN-gamma ... MHC class I gene promoter activity in astrocytes was controlled entirely through a single enhancer, the
MHC-IRF-E , to which IRF-1 bound in
response to
IFN-gamma in wild type but not in IRF-1 ( -/- ) mouse astrocytes ... MHC class I gene promoter activity in astrocytes was controlled entirely through a single enhancer, the MHC-IRF-E, to which
IRF-1 bound in
response to
IFN-gamma in wild type but not in IRF-1 ( -/- ) mouse astrocytes
Kirchhoff et al., J Immunol 2002
:
EMSAs demonstrate specific binding of
IFN-gamma induced
IFN-regulatory factor 1 (IRF-1) to the PRIDD sequences
Afrouzian et al., J Am Soc Nephrol 2002
(Necrosis) :
Because some effects of
IFN-gamma are
mediated by transcription factor
IRF-1 , the role of IRF-1 in the donor tissue early phases of rejection of mouse kidney allografts was studied
Ochi et al., Eur J Immunol 2002
:
Hyperosmotic medium also inhibited the expression of
IRF-1 induced by TNF-alpha or
IFN-gamma
Ramsauer et al., Proc Natl Acad Sci U S A 2002
:
Consistently,
IFN-gamma stimulated expression of the STAT1 target gene
IRF1 to a similar extent in both wild-type and p38alpha-deficient cells ... However, stress induced activation of the p38 MAPK pathway considerably enhanced the
IFN-gamma induced expression of both the endogenous
IRF1 gene and a reporter driven by the IFN-gamma activated sequence element of the IRF1 promoter
Chen et al., Exp Cell Res 2002
(Colonic Neoplasms) :
In this report, we showed that
IFN-gamma increased GKLF and
interferon regulatory factor-1 mRNA levels in a parallel fashion and these effects were abolished in STAT1 knockout mouse fibroblast cell lines, indicating that STAT1 mediated IFN-gamma stimulated GKLF gene expression
Elser et al., Immunity 2002
:
IRF-1 and IRF-2
induced by
IFN-gamma bind to three distinct IL-4 promoter sites and function as transcriptional repressors
Xi et al., Mol Immunol 2003
:
The
IFN-gamma activation of the CIITA type IV promoter is
mediated by STAT1 and
IRF-1 , which bind to the GAS and IRF-E of the promoter, respectively
Maruyama et al., J Immunol 2003
:
IFN-gamma induces
IFN regulatory factor-1 (IRF-1) , which in turn induces the transcription of the IL-12 p40 gene
Tomita et al., Int J Cancer 2003
(Carcinoma, Renal Cell...) :
These results suggest that
IRF-1 plays a pivotal role in the
IFN-gamma-mediated-enhancement of Fas/CD95 mediated apoptosis, through regulation of DEVD-CHO-sensitive caspases, most likely caspase-7
Salvati et al., Pediatr Res 2003
(Celiac Disease) :
Furthermore, stimulation of normal duodenal biopsies with
IFN-gamma enhanced
IRF-1
Tasheva et al., Molecular vision 2003
:
RT-PCR analyses demonstrate that
IFN-gamma rapidly and transiently suppresses mimecan expression and
induces IRF-1 and IRF-2 mRNAs in bovine corneal keratocytes
Chang et al., Immunogenetics 1992
:
These data suggest that
IRF-1 is
involved in the
IFN-gamma mediated induction of MHC class I expression
Giroux et al., J Immunol 2003
:
Overexpression of a dominant negative ( DN ) mutant of PKC-alpha inhibited the expression of IFN-gamma induced MHC-II but had no effect on
IFN-gamma induced STAT1 nuclear translocation and DNA binding activity, as well as on the expression of inducible NO synthase, IFN consensus sequence binding protein, MHC class I,
IFN regulatory factor (IRF)-1 , and IFN-gamma-inducible protein-10
Yim et al., J Interferon Cytokine Res 2003
(Breast Neoplasms...) :
The
role of
interferon regulatory factor-1 and interferon regulatory factor-2 in
IFN-gamma growth inhibition of human breast carcinoma cell lines ...
Interferon (IFN) regulatory factor-1 ( IRF-1 ) and IRF-2
play opposing roles in the regulation of many
IFN-gamma-inducible genes ... Finally, antisense oligonucleotides specific for IRF-1 attenuated IFN-gamma growth inhibition in MDA436 and MDA468, confirming the direct
role of
IRF-1 in
IFN-gamma growth inhibition
Hwa et al., J Biol Chem 2004
:
The
IFN-gamma induced regulation of the
interferon regulatory factor-1 gene, whose expression is dependent on activated STAT-1, was the same between CF and PF cells
Mitchell et al., Infect Immun 2004
:
STAT1 was unable to translocate from the cytoplasm to the nucleus in H. pylori infected HEp-2 cells examined by immunofluorescence, and reverse transcription-PCR showed that
IFN-gamma induced
interferon regulatory factor 1 expression was inhibited
Gira et al., J Invest Dermatol 2003
:
Induction of
interferon regulatory factor 1 expression in human dermal endothelial cells by
interferon-gamma and tumor necrosis factor-alpha is transcriptionally regulated and requires iron ... Both tumor necrosis factor-alpha and
interferon-gamma induced
interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription
Brucet et al., Genes Immun 2004
:
These results indicate that both STAT1 and
IRF-1 are
required for the
IFN-gamma induction of Tap-1 and Lmp-2 genes
Qiao et al., J Immunol 2004
:
IFN-gamma stimulation of infected cells
caused a synergistic increase in
IRF-1 transcription, yet IRF-1 mRNA abundance was similar in uninfected and infected cells stimulated by IFN-gamma, as was the IRF-1 protein level ... Moreover, the results indicate that regulated entry of nascent transcripts into the pool of total nuclear RNA affects
IRF-1 expression and that this process is
stimulated by
IFN-gamma and inhibited by M. tuberculosis
Ruiz-Ruiz et al., J Biol Chem 2004
(Breast Neoplasms) :
The up-regulation of human caspase-8 by
interferon-gamma in breast tumor cells
requires the induction and action of the transcription factor
interferon regulatory factor-1
Abadie et al., Oncogene 2004
(Bone Neoplasms...) :
We have shown that the presence of
IFNgamma is
required to allow the sustained expression of
IRF1 in SK-N-MC cells stimulated by addition of IFNalpha or TNFalpha suggesting that IRF1 plays a role in the synergistic induction of apoptosis by combinations of cytokines
Klampfer et al., J Biol Chem 2004
(Inflammation) :
Induction of
IRF-1 by
IFNgamma requires functional STAT1 signaling and was abrogated by butyrate, trichostatin A, suberoylanilide hydroxamic acid, and STAT1 small interfering RNA
Truchet et al., Biol Reprod 2004
:
In parallel, we showed that the transcription of two IFNgamma-target genes, namely
interferon regulatory factor-1 (IRF-1) and suppressor of cytokine signaling-1 ( SOCS-1 ) is indeed increased in two-cell embryos in
response to
IFNgamma
Lee et al., Neuroreport 2004
:
IFNgamma induced STAT-1 activation or
IRF-1 induction was not significantly influenced by PACAP
Pozharskaya et al., J Gen Virol 2004
:
Higher levels resulted from incubation with IFN-alpha than with IFN-gamma, whereas
IFN-gamma induced higher levels of
IRF-1 than did IFN-alpha
Jin et al., Clin Immunol 2004
(Disease Models, Animal...) :
Lack of
IRF-1 resulted in decreased CD8+ T cell number in the spleen and reduced
IFNgamma production by splenocytes
Lee et al., J Neuroimmunol 2004
:
In addition, ethanol pretreatment selectively regulated LPS induced NF-kappaB signaling pathway without affecting
IFNgamma induced signal transducer and activator of transcription 1 ( STAT1 ) phosphorylation,
interferon regulatory factor-1 (IRF-1) induction or IFNgamma-inducible IP-10 expression
Park et al., Eur J Biochem 2004
:
Western blotting analyses revealed that
IFN-gamma dramatically
increased the protein levels of interferon regulatory factor
(IRF)-1 , but not TRAIL receptors ( DR4 and DR5 ) and pro-apoptotic ( FADD and Bax ) and anti-apoptotic factors ( Bcl-2, Bcl-XL, cIAP-1, cIAP-2 and XIAP )
Nunez et al., Endocrinology 2005
:
IFN gamma rapidly
induces the expression of
IRF-1 proteins in a dose- and time dependent manner
Sheikh et al., Cardiovasc Res 2005
(Arteriosclerosis) :
Northern blotting showed that lysoPC transiently and dose-dependently inhibited the
IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48,
interferon regulatory factor-1 and guanidine binding protein-1 ... Northern blotting showed that lysoPC transiently and dose-dependently inhibited the
IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48,
interferon regulatory factor-1 and guanidine binding protein-1
Choi et al., Biochem Biophys Res Commun 2005
(Inflammation) :
In primary cultured rat brain astrocytes and C6 astroglioma cells, both cRA and tRA decreased
IFN-gamma induced expression of
interferon regulatory factor-1
Kollet et al., Mol Immunol 2006
:
IFN-gamma or LPS
stimulate nuclear localization of
IRF-1 or cRel/p50, respectively, in the RAW 264.7 macrophage cell line
Piskurich et al., Mol Immunol 2006
:
DNA binding of
IRF-1 and IRF-2, members of the IFN regulatory factor family, was up-regulated in B cells in
response to
IFN-gamma and increased the activity of CIITA pIV
Luo et al., J Biol Chem 2005
:
In this study, we have used the human lung epithelial cell line A549 to examine the effect of atRA on
IFNgamma induced expression of
IFN regulatory factor-1 (IRF-1) , an important transcription factor involved in cell growth and apoptosis, differentiation, and antiviral and antibacterial immune responses ... In addition, atRA pretreatment affected the transcriptional functions of
IFNgamma induced
IRF-1 , increasing its nuclear localization and DNA binding activity as well as the transcript levels of IRF-1 target genes ... These results suggest that atRA, an RARalpha ligand, regulates
IFNgamma induced
IRF-1 by affecting multiple components of the IFNgamma signaling pathway, from the plasma membrane to the nuclear transcription factors
Park et al., J Neuroimmunol 2005
:
In addition, it was found that sodium butyrate suppressed the
IFN-gamma induced
interferon regulatory factor 1 (IRF-1) expression via the inhibition of ERK
Chen et al., Eur J Pharmacol 2005
:
LPS induced IkappaB kinase (IKK), nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1) activation, and
IFN-gamma induced NF-kappaB, signal transducer and activator of transcription-1 ( STAT1 ) and
interferon regulatory factor-1 (IRF-1) activation were reduced by quercetin
Choi et al., J Neurosci Res 2005
(Alcohol-Induced Disorders, Nervous System...) :
Lipopolysaccharide (LPS), gangliosides, and interferon (IFN)-gamma induced the inflammatory activation of glia, which was differentially influenced by ethanol : 1 ) ethanol
inhibited LPS- or gangliosides induced, but not
IFNgamma induced, glial activation as demonstrated by the production of nitric oxide and the expression of inflammatory genes such as interleukin-1beta, tumor necrosis factor-alpha, IP-10, and CD86 ; 2 ) nuclear factor (NF)-kappaB or JAK/STAT1 pathway was necessary for LPS- or IFNgamma induced glial activation, respectively ; 3 ) ethanol inhibited LPS induced NF-kappaB activation ; and 4 ) ethanol did not significantly affect IFNgamma induced
STAT1/IRF-1 activation
Dimayuga et al., Arterioscler Thromb Vasc Biol 2005
(Carotid Artery Injuries...) :
Results further suggest that the effect of late
IFN-gamma in Rag-1KO mice is
mediated in part by increased
IRF-1 and iNOS expression, coupled with low SOCS1 expression
Shi et al., Int J Biochem Cell Biol 2006
(Breast Neoplasms...) :
Both treatments induced USF-1 and
IRF binding complexes to promoter IV but only
IFNgamma induced the binding of 435-Lung2 nuclear proteins to an ARE-1 site at the promoter III
Jia et al., Zhonghua Gan Zang Bing Za Zhi 2006
(Liver Neoplasms) :
IRF-1 , 2'5'-OAS1 ( p46 ), 2'5'-OAS2 ( p69 ) and ISGF3gamma may
mediate the anti-HCV effects of
interferon-gamma
Zhu et al., Int Immunol 2006
(MAP Kinase Signaling System) :
Furthermore, we demonstrated that there were no differences in
IFN-gamma induced signal transducer and activator of transcription-1 activation and consequent
interferon regulatory factor-1 and interferon consensus sequence binding protein up-regulation between pMphi and sMphi
Fujigaki et al., J Biochem 2006
:
Indoleamine 2,3-dioxygenase (IDO) is induced by
interferon (IFN)-gamma mediated effects of the signal transducer and activator of transcription 1alpha ( STAT1alpha ) and
interferon regulatory factor (IRF)-1
Bennett et al., Blood 2006
(Inflammation...) :
Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents
IFNgamma/tumor necrosis factor alpha (TNFalpha)
induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation,
IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival ... Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents
IFNgamma/tumor necrosis factor alpha (TNFalpha)
induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation,
IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Lafuse et al., J Interferon Cytokine Res 2006
:
However, the Mac101 strain, which is serovar 1, inhibited
IFN-gamma induction of
IFN regulatory factor-1 (IRF-1) and guanylate binding protein-1 (GBP-1) mRNA to a greater extent than the other M. avium strains, which are serovar 2
Negishi et al., Proc Natl Acad Sci U S A 2006
:
In this study we demonstrate that
IRF1 , which is
induced by
IFN-gamma , also interacts with and is activated by MyD88 upon TLR activation
Lengi et al., J Mol Endocrinol 2006
:
Given that
IFN-gamma is a potent
inducer of
IRF-1 , direct addition of recombinant IFN-gamma to splenocytes from either wild-type or IFN-gamma-knockout mice, or the addition of recombinant IFN-gamma to purified T-cells, was expected to stimulate IRF-1 expression ... Diminished
IFN-gamma induction of
IRF-1 in cells from estrogen treated mice was noticed despite comparable phosphorylated STAT-1 activation
Lui et al., Mol Pharmacol 2007
(Carcinoma, Squamous Cell...) :
Intact STAT1 signaling was demonstrated by
interferon-gamma (IFN-gamma) mediated induction of STAT1 phosphorylation ( Tyr701 ) and
interferon-regulatory factor-1 (IRF-1) expression
Buckley et al., Mol Cancer Res 2007
:
Using an Affymetrix U95A microarray,
IRF-7 was identified as a BRCA1 transcriptional target and was also shown to be synergistically up-regulated by BRCA1 specifically in the
presence of
IFN-gamma , coincident with the synergistic induction of apoptosis
Nikodemova et al., J Biol Chem 2007
(Demyelinating Autoimmune Diseases, CNS...) :
Interestingly, however, it was without effect on STAT1 phosphorylation or
IRF-1 expression, transcription factors that are
activated by
IFNgamma and necessary for CIITA expression ... Minocycline inhibited
IFNgamma induced PKC ( alpha/betaII ) phosphorylation and the nuclear translocation of both PKC ( alpha/betaII ) and
IRF-1 that subsequently inhibits CIITA expression
Sun et al., J Interferon Cytokine Res 2007
:
Expression of
IRF-1 was induced and expression of active caspase-3 was promoted by IFN-gamma treatment, but
IFN-gamma did not
affect the expression of IFNGR and p53
Van Der Fits et al., J Interferon Cytokine Res 2007
(Genetic Predisposition to Disease...) :
However, sequence analysis revealed no correlation between SNPs in the
IRF-1 promoter and
induction of
IFN-gamma or IL-10 expression
Kano et al., Nat Immunol 2008
:
Here we show that the
IFN-gamma induced transcription factor
IRF1 was essential in T ( H ) 1 differentiation by acting on Il12rb1, the gene encoding the IL-12 receptor beta1 subunit ( IL-12Rbeta1 ) ... Notably, the
IRF1 dependent induction of IL-12Rbeta1 was
essential for
IFN-gamma-IL-12 signaling but was dispensable for IL-23-IL-17 signaling
Schedel et al., Am J Respir Crit Care Med 2008
(Genetic Predisposition to Disease...) :
Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding,
IRF-1 gene expression, and
IFN-gamma regulation ... Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding,
IRF-1 gene expression, and
IFN-gamma regulation
Feng et al., Virology 2008
:
IFN-alpha activation of 6 of 7 endogenous ISRE regulated genes was also variably reduced, but not
IFN-gamma activated response element
mediated expression of
interferon regulatory factor 1
Hickey et al., J Leukoc Biol 2008
:
In contrast, CyaA suppressed LPS- and
IFN-gamma induced
IFN-regulatory factor-1 (IRF-1) and IRF-8 expression in DC
Fluhr et al., Fertil Steril 2009
:
Stimulation of
IRF-1 by
IFN-gamma is reduced in decidualized ESCs
Wort et al., J Biol Chem 2009
:
In contrast,
IFNgamma induced a delayed activation of
interferon regulatory factor-1 without any effect on NF-kappaB p65 nuclear localization or consensus DNA binding
Wang et al., Glia 2010
:
Using expression knock-down and forced overexpression methods, we directly demonstrated the
role of signal transducer and transcription activator 1 ( STAT1 ) and
interferon regulated factor 1 (IRF-1) in
IFN-gamma- induced OPC death
Shultz et al., J Interferon Cytokine Res 2009
:
Roles of IKK-beta,
IRF1 , and p65 in the activation of chemokine genes by
interferon-gamma ... In
response to
IFN-gamma , inhibitor of NF-kappaB (IkappaB) kinase beta ( IKK-beta ) is required to activate both newly synthesized
IRF1 and the p65 subunit of NF-kappaB, which contributes to ip-10 expression by binding to kappaB sites in the ip-10 promoter, with little or no activation of classical NF-kappaB
Ning et al., Mol Cancer Ther 2010
(Breast Neoplasms...) :
We show that
IFNgamma , but not IFNalpha, IFNbeta, or fulvestrant ( ICI ; ICI 182,780 ; Faslodex ),
induces IRF1 expression in antiestrogen-resistant MCF7/LCC9 and LY2 cells
Geller et al., Surgery 1993
:
The results showed that
IRF-1 is up-regulated in hepatocytes primarily in
response to
interferon-gamma and to a lesser extent after tumor necrosis factor-alpha or interleukin-1 beta stimulation
Panek et al., J Immunol 1995
:
TGF-beta does not act to inhibit IFN-gamma induced gene expression in a global fashion, as
induction of ICAM-1 and
IRF-1 gene expression by
IFN-gamma is unaffected by treatment with TGF-beta
Briken et al., Mol Cell Biol 1995
:
However, activation of the mouse Gbp promoter by
IFN-gamma requires transcription factor
IRF-1
Ohta et al., J Interferon Cytokine Res 1995
(Adenocarcinoma...) :
Northern analysis showed that IGR-5 cells responded to IFN-gamma and alpha, but the
enhancement of
IRF-1 expression by
IFN-gamma was markedly suppressed
Shin et al., J Biol Chem 1996
:
In contrast,
IFN-gamma induced and
activated interferon regulatory factor (IRF)-1 but had little effect on basal constitutive NF-kappa B activity
Karras et al., J Immunol 1996
:
Ag-receptor triggering in primary B lymphocytes stimulated nuclear expression of a complex that specifically binds the IFN response factor-1 (IRF-1) GAS sequence, and is distinguished by electrophoretic mobility and GAS preference from
IRF-1 GAS binding complexes
induced by
IFN-gamma
Drew et al., J Interferon Cytokine Res 1995
:
We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and
IFN-gamma induced binding of
IRF-1 to the adjacent interferon consensus sequence ( ICS )
Massa et al., J Neurochem 1996
:
Interferon-gamma induced
interferon regulatory factor 1 within 8 h, and GT1b suppressed this induction
Le Page et al., Immunology 1996
:
In addition,
IFN-gamma induced the
interferon regulatory factor-1 (IRF-1) gene and activated the binding of this factor to its target sequence in the iNOS gene
Sharf et al., J Biol Chem 1997
:
Tyr phosphorylated ICSBP and IRF-2 are detected in expressing cells constitutively, and Tyr phosphorylated
IRF-1 is
induced by
IFN-gamma
Aragane et al., J Immunol 1997
:
IFN-gamma significantly
induced IRF-1 binding, whereas UV treatment plus IFN-gamma decreased
IRF-1 binding, suggesting that UV light suppresses IFN-gamma induced expression of IL-7 by interfering with IRF-1
Piskurich et al., Mol Immunol 1997
:
Furthermore,
induction of the
IRF-1 promoter by
IFN-gamma correlates with induction of the pIgR promoter by IFN-gamma
Le Page et al., Adv Exp Med Biol 1997
:
We showed that inhibitors of ADP-ribosylation had no effect on
IFN-gamma mediated mRNA
induction of
IRF-1 nor on its activation and binding to its target sequence in the iNOS gene
Flodström et al., Endocrinology 1997
:
Interferon-gamma induced
interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production ... However,
IFN-gamma induced an early ( 30 min ( -1 ) h ) increase in
interferon regulatory factor-1 (IRF-1) mRNA expression and a later ( 2 h ) 19-fold increase in RIN cell nuclear IRF-1 protein content, an effect further potentiated by IL-1beta ... However, nicotinamide ( 20 mM ) presently failed to prevent IL-1beta +
IFN-gamma induced
IRF-1 protein expression in human pancreatic islets
Nazar et al., J Neuroimmunol 1997
(Glioblastoma) :
IFN-gamma and MV also
induced IRF-1 DNA binding activity which persisted for longer time periods with IFN-gamma stimulation
Lehtonen et al., J Immunol 1997
:
We show that IFN-alpha and
IFN-gamma rapidly and efficiently
enhanced STAT1, STAT2, p48, and
IRF-1 gene expression ...
IFN-gamma induced
IRF-1 gene expression more strongly than IFN-alpha
Rathbun et al., Blood 1997
(Anemia, Aplastic...) :
In normal human and murine HPC,
IFN-gamma primed the fas pathway and
induced both fas and
interferon response factor-1 (IRF-1) gene expression
Thomas et al., J Neuroimmunol 1997
:
Interferon regulatory factor 1 is
induced by
interferon-gamma equally in neurons and glial cells ... These experiments show that there is no defect in expression of
IRF-1 in
response to
IFN-gamma in mature mouse neurons but that insufficient class I MHC gene expression is induced for detectable cell surface protein expression
Ohmori et al., J Immunol 1997
:
IL-4 suppresses the
IFN-gamma induced expression of the
IFN regulatory factor-1 (IRF-1) gene, and this suppression is attenuated by increasing the amount of IFN-gamma ... These observations suggest that IL-4 may suppress
IFN-gamma stimulated transcription of the
IRF-1 gene by activation of STAT6, which can compete with STAT1 for occupancy of the IRF-1 SBE when STAT1 levels are low
Kanzaki et al., Endocrinology 1998
:
Identification and regulation of testicular interferon-gamma (IFNgamma) receptor subunits :
IFNgamma enhances
interferon regulatory factor-1 and interleukin-1beta converting enzyme expression
Agresti et al., Eur J Neurosci 1998
:
With respect to ICS element,
IFN-gamma induced
IRF-1 binding, that was further enhanced upon co-treatment with TNF-alpha ... This transcriptional
regulation of
IRF-1 gene by
IFN-gamma and TNF-alpha was confirmed at the mRNA level
Rohn et al., J Immunol 1999
(Astrocytoma) :
As well, IL-1beta treatment did not affect the ability of
IFN-gamma induced
interferon-regulatory factor-1 (IRF-1) to bind the IRF-1 element within the type IV CIITA promoter
Blanch et al., J Immunol 1999
:
We previously reported that
IFN-gamma and TNF-alpha
induce production of the transcription factor
IFN regulatory factor-1 (IRF-1) in HT-29 cells and that IRF-1 binds to an element in exon 1 of the PIGR gene ... We now report that levels of
IRF-1 and pIgR mRNA are coordinately
regulated in HT-29 cells by TNF-alpha,
IFN-gamma , and IL-1beta
Faure et al., J Biol Chem 1999
:
Analysis by reverse transcriptase-polymerase chain reaction, Western blot, and electrophoretic mobility shift assay demonstrated that
IFN-gamma alone or combined with LPS
induced an accumulation of IRF-1 mRNA and protein and
IRF-1 DNA binding ... The decrease of
LPS/IFN-gamma induced IRF-1 promoter activity,
IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds ... The decrease of
LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and
IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds