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BCL3 — RELA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
BCL3
—
RELA
(physical association, affinity chromatography technology)
Barré et al., EMBO J 2007
-
IRef Biogrid Interaction:
BCL3
—
RELA
(colocalization, imaging technique)
Barré et al., EMBO J 2007
-
MIPS CORUM ESR1-RELA-BCL3-NCOA3 complex:
ESR1-RELA-BCL3-NCOA3 complex complex (BCL3-ESR1-NCOA3-RELA)
Rubio et al., Oncogene 2006*
-
IRef Corum Interaction:
Complex of BCL3-ESR1-RELA-NCOA3
(association, coimmunoprecipitation)
Rubio et al., Oncogene 2006*
-
IRef Intact Interaction:
Complex of RELB-NFKB1-NFKB2-REL-SIN3A-RELA-BCL3
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of NFKB2-RELA-NFKB2-SIN3A-BCL3-NFKB1
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of BCL3-NFKB1-NFKB2-REL-SIN3A-RELA-NFKB2-RELB
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
Text-mined interactions from Literome
Badrichani et al., J Clin Invest 1999
:
In addition, Bcl-2 or
Bcl-XL inhibits activation of
NF-kappaB and thus upregulation of proinflammatory genes
Bertin et al., J Biol Chem 2000
:
Although its role in apoptosis remains to be determined,
BCL10 likely
activates NF-kappaB through the IKK complex in response to upstream stimuli
Brasier et al., J Biol Chem 2001
:
Two observations are interpreted to indicate that bcl-3 is transactivated by NF-kappa B/Rel A : 1 ) expression of a dominant negative NF-kappa B inhibitor blocks tumor necrosis factor-alpha induced BCL-3 expression and 2 ) expression of constitutively active
Rel A is
sufficient to induce
BCL-3 expression ... Down-regulation of
BCL-3 induction
results in prolonged, enhanced
NF-kappa B1 binding and increased NF-kappa B-dependent transcription
Rocha et al., Mol Cell Biol 2003
:
p53 represses cyclin D1 transcription through down regulation of
Bcl-3 and
inducing increased association of the p52
NF-kappaB subunit with histone deacetylase 1
Corn et al., J Immunol 2003
:
Further, induced expression of
Bcl-3 , a trans activating IkappaB-like protein, is decreased in T cells as a
consequence of
NF-kappaB inhibition
Yorke et al., Eur J Cancer 2003
(Adenocarcinoma...) :
Receptor activator of
NF-kappaB ( RANK ) activation
induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of
Bcl-xL
Ge et al., J Immunol 2003
:
NF-kappa B regulates
BCL3 transcription in T lymphocytes through an intronic enhancer ... Together, these results demonstrate a critical
role for
NF-kappaB in
BCL3 transcriptional up-regulation by TCR-mimetic signals
Chen et al., Apoptosis 2004
(Colonic Neoplasms) :
Bcl-2, and to the less extent,
Bcl-xL , were able to
increase the activity of
NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Tran et al., J Biol Chem 2005
(Astrocytoma...) :
In addition, Fn14 activation induced
BCL-XL and BCL-W mRNA and protein levels, and this effect was
dependent upon
NFkappaB transcriptional activity ... Our results suggest that
NFkappaB mediated up-regulation of BCL-XL and
BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
Furthermore,
BCL10 and cIAP2-MALT1 synergistically
activate NF-kappaB
Tao et al., Mol Cell Biol 2006
:
Up-regulation of proapoptotic protein
Bcl-XS and neuronal apoptosis induced by serum deprivation are
blocked by inhibition and/or down-regulation of
NF-kappaB and by prevention of K+ loss
Massoumi et al., Cell 2006
(Skin Neoplasms) :
Cyld inhibits tumor cell proliferation by blocking
Bcl-3 dependent
NF-kappaB signaling
Khanbolooki et al., Mol Cancer Ther 2006
(Pancreatic Neoplasms) :
NF-kappaB inhibition
resulted in down-regulation of
BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Deeb et al., J Pharmacol Exp Ther 2007
(Prostatic Neoplasms) :
Because expression of antiapoptotic Bcl-2,
Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is
regulated by
NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
de Kozak et al., Am J Pathol 2007
(Inflammation...) :
At 24 hours after lipopolysaccharide stimulation, nuclear NF-kappaB/p65 decreased and nuclear
NF-kappaB/p50 increased , associated with nuclear
BCL-3 and a low level of TNF-alpha, indicating onset of spontaneous resolution
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2,
Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Takase et al., Kidney Int 2008
(Chronic Disease...) :
Inhibition of
NF-kappaB dependent
Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated
NF-kappaB and STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Aimbire et al., Int Immunopharmacol 2008
(Inflammation) :
LLLT and an inhibitor of
NF-kappaB nuclear translocation ( BMS 205820 )
attenuated the mRNA levels of
Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009
(Adenocarcinoma...) :
NFkappaB DNA binding activity and
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes
Patel et al., J Leukoc Biol 2009
(Disease Susceptibility...) :
IL-10 did not influence p-IRAK, IkappaB degradation, or NF-kappaB p65 nuclear translocation in response to MTb, but IL-10 did increase levels of AM
BCL-3 , an
inhibitor of
NF-kappaB nuclear activity
Banerjee et al., Cancer Res 2009
(Pancreatic Neoplasms) :
Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced
activation of
NF-kappaB and its downstream genes (
Bcl-xL , XIAP, cIAP, and survivin )
Jinawath et al., PloS one 2010
(Ovarian Neoplasms) :
Combined ectopic expression of
RELA and STAT5B
enhanced Bcl-xL promoter activity while treatment with BMS-345541 and Dasatinib decreased it
Zhang et al., Mol Cell Biol 1994
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In contrast to I kappa B alpha ( MAD3 ),
BCL3 does not
cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Nolan et al., Mol Cell Biol 1993
:
At concentrations that significantly inhibited DNA binding by homodimeric p50,
Bcl-3 did not
inhibit binding of reconstituted heterodimeric
NF-kappa B ( p50 : p65 ), a DNA binding homodimeric form of p65, or homodimers of c-Rel
Bundy et al., J Biol Chem 1997
:
Diverse
effects of
BCL3 phosphorylation on its modulation of
NF-kappaB p52 homodimer binding to DNA