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CARD16 — RELA
Text-mined interactions from Literome
Koseki et al., J Biol Chem 1999
:
Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the
CARD is
essential for
NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000
:
When expressed in cells,
CARD9 binds to BCL10 and
activates NF-kappaB
Bertin et al., J Biol Chem 2001
:
When expressed in cells,
CARD11 and CARD14
activate NF-kappaB and induce the phosphorylation of BCL10
Druilhe et al., Cell Death Differ 2001
:
Moreover,
Pseudo-ICE , but not ICEBERG, interacts with the CARD containing kinase RICK/RIP2/CARDIAK and
activates NF-kappaB ... Our data suggest that
Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could
play a role in the regulation of IL-1beta secretion and
NF-kappaB activation during the pro-inflammatory cytokine response
Fontalba et al., J Immunol 2007
(Arthritis, Rheumatoid) :
Thus,
CARD8 may
control NF-kappaB activation through a regulatory loop