Gene interactions and pathways from curated databases and text-mining

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IL2 — IL2RG

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Dai et al., J Immunol 1999 : IL-2 up-regulated Fas ligand (FasL) and down-regulated gamma c expression on activated 2C cells in vitro and in vivo
Olosz et al., J Biol Chem 2000 (Severe Combined Immunodeficiency...) : Using a model based site directed mutagenesis strategy, we have identified residues of the mouse gammac extracellular domain that are required for normal gammac dependent enhancement of IL-2 and IL-7 binding
Ginn et al., Hum Mutat 2004 (Genetic Diseases, X-Linked...) : Atypical phenotypes have also been described, but relatively little is known about the mechanisms by which the underlying mutations impair gammac dependent interleukin receptor signalling to produce these disease variants
Metcalfe et al., Open biology 2012 (Common Variable Immunodeficiency...) : We postulate that reduction of the Cys ( 183 ) -Cys ( 232 ) disulfide in CD132 inhibits IL-2 binding to the receptor complex
Granelli-Piperno et al., J Exp Med 1986 : Exogenous IL-2 had little ( IFN ) or no ( IL-2 ) effect on lymphokine mRNAs, but significantly increased c-myc, IL-2-R and heat shock protein mRNAs
Yodoi et al., J Immunol 1985 (Cell Transformation, Neoplastic...) : Furthermore, neither recombinant IL 2 nor gamma-interferon could induce IL 2-R on YT cells, suggesting the presence of a unique IL 2-R inducing factor in PBL or spleen CM
Nishimura et al., J Immunol 1989 : In contrast, IL-2 induced cell proliferation, IL-2R expression, and LFA-1 expression were enhanced by the addition of PMA
Reed et al., Proc Natl Acad Sci U S A 1986 : These data indicate that c-fos, c-myc, IL2 , and IL2R belong to a group of genes expressed early, whereas c-myb, N-ras, and TFR belong to a group of genes expressed later in PHA activated PBMC, and that the products of the c-fos and c-myc protooncogenes are not required for expression of IL2 or IL2R genes
Nagel et al., J Clin Invest 1988 : The results suggest that decreased expression of both IL2 and IL2R mRNA contributes to the low synthesis of IL2 and membrane IL2R , respectively, and is partially responsible for the diminished proliferative activity observed in lymphocytes from the elderly
de Totero et al., Leukemia & lymphoma 1994 (Leukemia, Hairy Cell) : Since in variant HCL the IL2 receptor alpha chain could not be induced by different stimuli, it appears that the CD25 antigen may not be essential in the process of IL2 promoted growth, while p75 and p64 play a primary role in IL2 activation
Hacein-Bey et al., Blood 1996 (Severe Combined Immunodeficiency) : gamma-c gene transfer into SCID X1 patients ' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function
Toyooka et al., Int Immunol 1996 : Conversely, IL-2R was not induced by bm12 B cell stimulation in the presence of IL-2
Liu et al., Cytokine 1996 : A cell line expressing human IL-2r alpha and IL-2r beta along with murine gamma c vigorously proliferated only in response to human IL-2 at low doses, while both human and murine IL-2 stimulated proliferation of a cell line containing murine IL-2r alpha ( as well as human IL-2r beta and murine gamma c )