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CEBPB — TNF

Text-mined interactions from Literome

Andoh et al., Clin Exp Immunol 1999 : The EMSAs indicated that sodium butyrate suppressed TNF-alpha induced nuclear factor (NF)-kappaB- and activation protein (AP)-1-DNA binding activity, but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity
Cardinaux et al., Glia 2000 : Here we show that lipopolysaccharides (LPS), IL-1beta, and TNFalpha induce the expression of the c/ebpbeta and -delta genes in mouse primary astrocytes
Kurebayashi et al., Endocr J 2001 : In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma
Buck et al., EMBO J 2001 (Cachexia) : Here we show that tumor necrosis-alpha ( TNF-alpha ) treatment of primary mouse hepatocytes or TNF-alpha overexpression in a mouse model of cachexia induces oxidative stress, nitric oxide synthase (NOS) expression and phosphorylation of C/EBPbeta on Ser239, within the nuclear localization signal, thus inducing its nuclear export, which inhibits transcription from the albumin gene
Jana et al., J Neurochem 2002 : However, CD40 ligation alone in the presence or absence of CD40 overexpression induced the activation of only NF-kappaB and not that of C/EBPbeta, suggesting that the activation of NF-kappaB alone by CD40 ligation is not sufficient to induce the expression of TNF-alpha and that the activation of C/EBPbeta is also necessary for strong induction of TNF-alpha ... Taken together, these studies suggest that activation of both NF-kappaB and C/EBPbeta is important for strong induction of TNF-alpha and that CD40 ligation regulates the expression of TNF-alpha by modulating the activation of only NF-kappaB but not that of C/EBPbeta
Webb et al., J Dent Res 2002 (Osteosarcoma) : Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that NFkappaB activity was enhanced and that constitutive C/EBPbeta was inhibited by TNF-alpha , with both effects being p38 MAPK dependent
Liu et al., J Biochem Mol Toxicol 2002 : Based on the knowledge that TNFalpha preferentially affects C/EBPalpha and that TGFbeta specifically controls C/EBPbeta and delta in their antiadipogenic action, we hypothesized that the major cause for the differential response of these two similar cell lines could be the insensitivity of C/EBPbeta and/or delta of F442A cells to the action of TCDD
Jana et al., J Neurochem 2003 : Activation of NF-kappaB as well as C/EBPbeta by p40 and inhibition of p40 induced expression of TNF-alpha by Deltap65, a dominant negative mutant of p65, and DeltaC/EBPbeta, a dominant negative mutant of C/EBPbeta, suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta
Papin et al., J Biol Chem 2003 (Familial Mediterranean Fever) : The tumor necrosis factor alpha dependent activation of the human mediterranean fever (MEFV) promoter is mediated by a synergistic interaction between C/EBP beta and NF kappaB p65
Chojkier et al., J Clin Gastroenterol 2005 (Cachexia) : In turn, TNF-alpha stimulates oxidative stress, NO synthesis, and phosphorylation of C/EBP-beta within its nuclear localization signal ( NLS )
Karagiannides et al., J Biol Chem 2006 : Tumor necrosis factor-alpha , levels of which are elevated in fat tissue with aging, increased CUGBP1 protein, CUGBP1 binding activity, and C/EBPbeta-LIP in preadipocytes from young rats
Saha et al., J Neuroimmune Pharmacol 2006 : Similarly, TNF-alpha induced the activation of C/EBPbeta and the expression of BDNF was sensitive to overexpression of DeltaC/EBPbeta ( a dominant negative mutant ) and ETO ( an inhibitor of C/EBPbeta )
Ignatova et al., Am J Physiol Endocrinol Metab 2009 (Carcinoma, Hepatocellular...) : In conclusion, C/EBPalpha and C/EBPbeta control basal transcription, and TNF-alpha upregulates 11beta-HSD1, most likely by p38 MAPK mediated increased binding of C/EBPbeta to the human HSD11B1 promoter
Xu et al., Stem Cells 2009 : We further found that, while either IFNgamma or TNFalpha alone induced minor expression of C/EBPbeta in MSCs, this transcription factor was dramatically upregulated when these cytokines were added together ... Furthermore, while STAT1 is critical in IFNgamma signaling, we found that STAT1 knockdown in MSCs did not affect C/EBPbeta expression or the synergistic induction of IL-6 and CXCL1 by IFNgamma and TNFalpha
Dai et al., J Cell Biochem 2009 : Binding of the NF kappaB p65 subunit and C/EBP beta to this element is induced by TNF alpha
Pope et al., J Clin Invest 1994 : C/EBP beta regulation of the tumor necrosis factor alpha gene ... We present data to show that the expression of TNF alpha is regulated by the transcription factor C/EBP beta ( NF-IL6 ) ... C/EBP beta activated the TNF alpha gene promoter in cotransfection assays and bound to it at a site which failed to bind the closely related protein C/EBP alpha
Zagariya et al., Mol Cell Biol 1998 : Previously, we found that the monocyte/macrophage enriched nuclear transcription factor C/EBPbeta played an important role in the regulation of the TNF alpha gene in myelomonocytic cells ... Our data demonstrate that the TNF alpha gene is regulated by the interaction of the ubiquitous AP-1 complex protein c-Jun and the monocyte/macrophage enriched transcription factor C/EBPbeta and that this interaction contributes to the expression of the cellular TNF alpha gene in myelomonocytic cells
Catron et al., Cell Growth Differ 1998 : Functional studies with various reporter gene constructs revealed that both binding sites were required for maximal activation of the ICAM-1 promoter in response to TNF-alpha and for synergistic activation by RelA and C/EBPbeta