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FGF2 — FGFR3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FGFR3 → FGF2 (increases) Ishikawa et al., J Clin Exp Hematop 2006*
  Evidence: Figure 5. This is a figure in the review representing the cross talk between FGFR3 and IL6 signaling in multiple myeloma cell line KH11; the legend is as follows: Fig. 5. Enhanced proliferation of myeloma cells by interleu- kin- 6 cooperatingwith FGFR3-mediated signals. IL- 6 and FGF induce the distinct intracellular signaling pathways in myeloma cells carryingt(4 ;14)(p16. 3 ;q32) that ectopically express FGFR3. FGF and IL- 6 activate ERK1/ 2, PI- 3 kinase and STAT3, respectively. The serine ph...
• KEGG MAPK signaling pathway: FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9 → FGFR1/FGFR2/FGFR3/FGFR4 (protein-protein, activation)
• KEGG Pathways in cancer: FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9 → FGFR1/FGFR2/FGFR3 (protein-protein, activation)
• Reactome Reaction: FGF2 → FGFR3 (direct_complex) Hart et al., Mol Biol Cell 2001, Mohammadi et al., Nature 1992, Mohammadi et al., Mol Cell Biol 1991, Mohammadi et al., Mol Cell Biol 1996
• Reactome Reaction: FGF2 → FGFR3 (reaction) Carpenter et al., Exp Cell Res 1999, Yu et al., Proc Natl Acad Sci U S A 2000, Hart et al., Mol Biol Cell 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Mohammadi et al., Nature 1992, Agazie et al., Oncogene 2003, Ibrahimi et al., Hum Mol Genet 2004, Ibrahimi et al., Hum Mol Genet 2004, Mohammadi et al., Cytokine Growth Factor Rev 2005, Mohammadi et al., Mol Cell Biol 1991, Zhang et al., J Biol Chem 2006, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Schüller et al., Biochem J 2008, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Mohammadi et al., Mol Cell Biol 1996, Ong et al., Biochem Biophys Res Commun 1996, Bellus et al., Nat Genet 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Reardon et al., J Med Genet 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998
• Reactome Reaction: FGF2 → FGFR3 (indirect_complex) Yu et al., Proc Natl Acad Sci U S A 2000, Ibrahimi et al., Hum Mol Genet 2004, Ibrahimi et al., Hum Mol Genet 2004, Mohammadi et al., Cytokine Growth Factor Rev 2005, Zhang et al., J Biol Chem 2006, Bellus et al., Nat Genet 1996, Reardon et al., J Med Genet 1997
• WikiPathways ESC Pluripotency Pathways: FGF1/FGF16/FGF6/FGF19/FGF22/FGF10/FGF9/FGF20/FGF11/FGF17/FGF18/FGF14/FGF23/FGF5/FGF2/FGF12/FGF21/FGF3/FGF7/FGF8/FGF4 → FGFR1/FGFR3/FGFR4/FGFR2 (activation)
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  
• WikiPathways Neural Crest Differentiation: FGF2/FGF8/FGF19 → FGFR1/FGFR2/FGFR3 (mim-binding)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: FGFR3 — FGF2 (physical association, coimmunoprecipitation) Kanai et al., J Biol Chem 1997
• IRef Hprd Interaction: FGFR3 — FGF2 (in vivo) Chellaiah et al., J Biol Chem 1999
• IRef Ophid Interaction: FGFR3 — FGF2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Richardson et al., J Biol Chem 1999 : The cell density dependent change in bFGF binding was not the result of altered FGFR expression as determined by equilibrium binding experiments and by immunoblot analysis
Wang et al., Growth Factors 2000 : The biological activities of fibroblast growth factors ( FGF ) are mediated by specific cell membrane receptors ( FGFR ), which have three immunoglobulin-like IgG domains in the extracellular region
Cohen et al., J Neurosci Res 2000 : The effects of FGF-9 and FGF-2 on FGFR and myelin protein levels were comparable ; both up-regulated FGFR-1, and down-regulated FGFR-2, CNP, PLP and MBP
Cailliau et al., Biochim Biophys Acta 2001 : In contrast, FGFR4 stimulation by FGF2 induced an early transient activation of ERK2 and no meiosis reinitiation
Pellegrini et al., Curr Opin Struct Biol 2001 : Fibroblast growth factors ( FGFs ) are among the best studied heparin binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR
Anderson et al., J Neurochem 2005 : Dendrimeric FRM peptide was 125-fold more active and stimulated FGFR activation, FGFR dependent and FGF-mimetic neurite outgrowth and cell survival ( but not proliferation )
Hatziapostolou et al., J Biol Chem 2006 (Prostatic Neoplasms) : Using a combination of Western blot analyses, as well as genetic and pharmacological inhibitors, we found that activation of FGFR by FGF2 in LNCaP cells leads to NAD ( P ) H oxidase dependent hydrogen peroxide production, phosphorylation of ERK1/2 and p38, activation of AP-1, increased expression and secretion of HARP, and, finally, increased cell proliferation and migration
Cushing et al., Biomaterials 2007 : Fibroblast growth factor receptor ( FGFR ) activation by basic fibroblast growth factor ( FGF-2 ) serves to naturally repress the myofibroblast activation of valvular interstitial cells ( VICs )
Buratini et al., Biol Reprod 2007 : Whereas many FGFs activate several FGF receptors, FGF7 and FGF10 primarily activate only one, FGFR2B
Nur-E-Kamal et al., Mol Cell Biochem 2008 : Covalently bound FGF-2 also strongly activated FGFR , extracellular signal regulated kinase ( ERK1/2 ), and c-fos
Ditlevsen et al., Neurochem Int 2008 : For comparison, we also evaluated the role of upstream signalling cascades on fibroblast growth factor 2 (FGF2) mediated phosphorylation of ERK, Akt, and CREB and found that FGF2 required the activity of both FGFR and Src-family kinases for phosphorylation of ERK, Akt, and CREB
Park et al., Growth Factors 2009 : bFGF also increased the expression of FGFR , which in turn increased expression of insulin-like growth factor ( IGFs )
Xiao et al., J Biol Chem 2010 (Hypophosphatemia...) : The results suggest that overexpression of HMW FGF2 increases FGF23/FGFR/KLOTHO signaling to down-regulate NPT2a, causing P ( i ) wasting, osteomalacia, and decreased BMD
Lai et al., Stem Cells 2011 : Fgf2 also induced expression of Fgf receptor 1 (Fgfr1) and Fgfr4 and repressed Fgfr2 and Fgfr3 expression in MSCs, whereas Wnt3a and Bmp2 had the opposite effect
Li et al., Mol Cell Endocrinol 2012 : In hepatocyte, FGF-21 up-regulation reduced HMGR and PEPCK mRNA expression and increased ß-klotho, FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Yan et al., Arthritis Res Ther 2011 (Osteoarthritis) : Our results also demonstrate that FGFR3 was negatively regulated by FGF-2 at the transcriptional level through the FGFR1-ERK ( extracellular signal regulated kinase ) signaling pathway in human articular chondrocytes
Ahmad et al., Biochim Biophys Acta 2012 (Cell Transformation, Neoplastic...) : FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy
Huang et al., Neurobiol Dis 2012 (Cerebral Hemorrhage, Traumatic) : Exogenous FGF2 increased activated FGFR , Akt, and Rac1 but reduced activated RhoA protein expression at 72 h after cICH ( p < 0.05, compared to vehicle ), which was reversed by FGFR and PI3K inhibition
Rusnati et al., Biochem Biophys Res Commun 1994 : Interaction of basic fibroblast growth factor (bFGF) with heparan sulfate proteoglycans ( HSPGs ) plays an important role in the binding of bFGF to its tyrosine kinase receptor ( FGFR )
Itoh et al., Development 1996 : These results suggest that the FGFR mediated FGF signaling ( 1 ) blocks terminal differentiation of myogenic cells within the somite and ( 2 ) sustains myoblast migration to limb buds from the somite, and that ( 3 ) down-regulation of FGFRs or FGFR signaling is involved in mechanisms triggering terminal differentiation of the limb muscle mass during avian embryogenesis
Santos-Ocampo et al., J Biol Chem 1996 : Significantly, FGF-9 also binds to and activates the `` b '' splice form of FGFR3 , thus becoming the first FGF ligand besides FGF-1 to activate this highly specific member of the FGF receptor family
Estival et al., J Biol Chem 1996 : Increasing cell densities or cell treatment with exogenous FGF-2 resulted in FGFR down-regulation as in control cells
Ballabriga et al., Brain Res 1997 : bFGF and FGFR-3 immunoreactivity in the rat brain following systemic kainic acid administration at convulsant doses : localization of bFGF and FGFR-3 in reactive astrocytes, and FGFR-3 in reactive microglia
McKeehan et al., Prog Nucleic Acid Res Mol Biol 1998 : Divalent cations cooperate with the FGFRHS to conformationally restrict FGFRTK trans-phosphorylation, which causes depression of kinase activity and facilitates appropriate activation of the FGFR complex by FGF