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EPHB2 — IL8

Text-mined interactions from Literome

Venkatakrishnan et al., J Biol Chem 2000 (Ovarian Neoplasms) : Treatment of SK-OV-3 cells with the inhibitors genestein and herbimycin A indicated that tyrosine kinases were involved in the IL-8 activation of Erk1 and Erk2
Valledor et al., J Biol Chem 2000 : Granulocyte/macrophage colony stimulating factor, interleukin 3, and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation
Alcorn et al., J Virol 2001 (Adenoviridae Infections) : Further, the kinetics of Erk activation and IL-8 induction suggest that an early viral event, such as receptor binding, may be responsible for the observed inflammatory response
Savkovic et al., Am J Physiol Gastrointest Liver Physiol 2001 (Inflammation...) : ERK1/2 inhibitors attenuated IkappaBalpha degradation and IL-8 expression
Na et al., Int Immunopharmacol 2001 : Collectively, this series of experiments indicates that radicicol inhibits IL-8 gene expression by blocking ERK1/2 and p38 signaling
Wang et al., J Biol Chem 2002 : Moreover, IL-8 mRNA stability was significantly enhanced by FVIIa induced activation of the mitogen activated protein kinases ERK1/2 and p38
Jijon et al., Am J Physiol Cell Physiol 2002 : In contrast, ERK and p38 inhibition resulted in the accelerated degradation of the IL-8 mRNA, suggesting that in HT-29 cells, p38 and ERK contribute to TNF-alpha stimulated IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism that involves stabilization of the IL-8 transcript
Ameixa et al., Infect Immun 2002 (MAP Kinase Signaling System) : Interleukin-8 secretion from Mycobacterium tuberculosis infected monocytes is regulated by protein tyrosine kinases but not by ERK1/2 or p38 mitogen activated protein kinases
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Recent studies indicate that maximal IL-8 protein expression requires activation of NF-kappaB as well as activation of the MAP kinases ERK , JNK, and p38
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : ERK activation is required for double stranded RNA- and virus induced interleukin-1 expression by macrophages
Bian et al., Exp Eye Res 2003 (Translocation, Genetic) : In addition, anti-inflammatory drugs dexamethasone ( DEX ) and cyclosporin A ( CSA ) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA
Li et al., Am J Physiol Lung Cell Mol Physiol 2003 (MAP Kinase Signaling System) : We exposed A549 cells, a type II-like alveolar epithelial cell line, to cyclic stretch at 20 cycles/min for 5 min-2 h. Cyclic stretch induced IL-8 protein production, IL-8 mRNA expression, and JNK activation, but only transient activation of p38 and ERK1/2 ... Inhibition of p38 and ERK1/2 did not affect stretch induced IL-8 production
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The protein tyrosine phosphatase SHP-2 regulates interleukin-1 induced ERK activation in fibroblasts
Song et al., J Clin Immunol 2003 (Tuberculosis) : However, IL-8 secretion was not regulated by ERK1/2 or p38 MAPK
Akhtar et al., FASEB J 2003 (MAP Kinase Signaling System) : Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 MAPK and inhibitors of ERK activity ( PD98059, UO126 ) significantly reduced the evoked IL-8 production
Xie et al., J Immunol 2003 : Furthermore, LPS up-regulated the secretion of IL-1beta, IL-6, IL-8 , IL-10, and TNF-alpha ; reduced Ag presentation capacity ; and inhibited phosphorylation of ERK , but activated p38, leading to a reduced NF-kappaB activity in treated cells
Chen et al., J Biomed Sci 2004 (MAP Kinase Signaling System) : A specific inhibitor of p38 MAPK ( SB203580 ) and an NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), but not an ERK inhibitor ( PD 98059 ), significantly inhibited neutrophil elastase induced IL-8 release and mRNA expression
Grab et al., Biochim Biophys Acta 2004 : The ERK and p38 MAPKs can also stimulate the expression of both cyclooxygenase-2 (Cox-2) and interleukin-8 (IL-8)
Booth et al., J Virol 2004 (Adenovirus Infections, Human...) : Adenovirus type 7 induces interleukin-8 in a lung slice model and requires activation of Erk
Cowburn et al., Eur J Immunol 2004 : Inhibition of I kappa B-alpha phosphorylation, PI3-kinase or ERK1/2 activation blocked IL-8 release by both cytokines ... These data suggest that cross-talk between NF-kappa B and PI3-kinase pathways in TNF-alpha -stimulated neutrophils results from NF-kappa B/ERK1/2 dependent IL-8 production which acts in an autocrine manner to drive PI3-kinase dependent survival
Vitiello et al., Cytokine 2004 (MAP Kinase Signaling System) : In this report, we demonstrate, using two potent and selective inhibitors of MEK activation by Raf-1 ( PD-098059 ) and p38 ( SB-203580 ), that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS
Chang et al., J Biol Chem 2004 (Inflammation...) : The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation
Krüll et al., Infect Immun 2004 : Subsequent interleukin-8 (IL-8) expression was dependent on p38-MAPK and ERK1/2 activation as demonstrated by preincubation of endothelial cells with specific inhibitors for the p38-MAPK ( SB202190 ) or ERK ( U0126 ) pathway
Fuhler et al., J Leukoc Biol 2005 (Myelodysplastic Syndromes) : In accordance with these results, we subsequently showed that IL-8/GROalpha stimulated activation of ERK1/2 was substantially diminished in MDS neutrophils ... IL-8 stimulation resulted in higher migratory behavior and ERK1/2 activation than GROalpha stimulation, suggesting a greater importance of CXCR1
Wang et al., J Biol Chem 2005 : SHP-2 modulates interleukin-1 induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
Jijon et al., Eur J Immunol 2005 : SAA dependent IL-8 gene expression required activation of the MAPK ERK , p38 and JNK in HT-29 cells
Torok et al., Infect Immun 2005 : In contrast, inhibition of JNK and/or ERK resulted in substantially less IL-8 secretion from infected cells, independent of TLR2 or TLR5 expression
Wang et al., Cell Signal 2005 (MAP Kinase Signaling System...) : Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells leads to IL-6 or IL-8 secretion
Miranda et al., Leuk Res 2005 (MAP Kinase Signaling System) : Additionally, interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also inhibited the ability of G-CSF to stimulate prolonged MEK/ERK activation
Kim et al., Int Immunol 2005 (MAP Kinase Signaling System) : Exposure of the cells to CpG ODN resulted in a time- and dose dependent increase of IL-8 expression, and activation of phosphorylated ERK1/2 and phosphorylated p38
Wang et al., Oncogene 2006 (Colonic Neoplasms) : Treatment with SB-216763 increased expression of cyclooxygenase-2 (COX-2) and IL-8, which are downstream targets of ERK1/2 activation ; this induction was abolished by MEK/ERK inhibition, suggesting GSK-3 inhibition induced COX-2 and IL-8 through ERK1/2 activation
Kim et al., Cytokine 2005 : Pretreatment of MAPK inhibitors ( PD98059 and SB203580 ) markedly blocked Ca ( 2+ ) -induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2
Kim et al., Am J Physiol Lung Cell Mol Physiol 2006 : Zn2+ induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells
Wong et al., Allergy 2006 : Using various selective inhibitors for signaling molecules, we found that the inductions of IL-8 , MCP-1, and I-309 were mediated by either SCF activated ERK or TNF-alpha activated p38 MAPK, while the induction of IP-10 by TNF-alpha was mediated by both activated p38 MAPK and NF-kappaB
Matsubara et al., Int Arch Allergy Immunol 2006 : Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen activated protein/ERK kinase inhibitor, suppressed the histamine induced ERK activation and the production of granulocyte macrophage colony stimulating factor and IL-8
Liu et al., Biochem Biophys Res Commun 2006 (Prostatic Neoplasms) : Inhibitors of either extracellular signal regulating kinase ( ERK ) or phosphatidylinositol 3-kinase (PI3K) partly reversed the thrombin induced cytokine expression, suggesting that both ERK and PI3K kinase pathways may be involved in IL-8 and VEGF expression
Wang et al., Int J Biochem Cell Biol 2006 : Induction of interleukin-8 secretion and activation of ERK1/2 , p38 MAPK signaling pathways by thrombin in dermal fibroblasts
Kooijman et al., Int J Biochem Cell Biol 2006 : We previously established that stimulation by IGF-I of interleukin (IL)-8 expression in leukocytes required activation of extracellular regulated kinase (ERK) and basal activity of c-Jun N-terminal kinase (JNK)
Alvarez et al., J Immunol 2006 (MAP Kinase Signaling System) : When analyzing the role of these pathways on neutrophil functions, we observed that up-regulation of CD11b triggered by bacterial DNA was decreased by pharmacological inhibitors of the p38 MAPK, ERK1/2, and JNK, whereas stimulation of IL-8 release was dependent on p38, ERK1/2 , and NF-kappaB
Yoshida et al., Int J Mol Med 2007 : Blocking antibody to PAR2, camostat mesilate ( a trypsin inhibitor ), p-38 mitogen activated protein kinase ( MAPK ) inhibitors or ERK1/2 inhibitors reduced IL-8 production from trypsin stimulated HEEC
Nakanaga et al., Am J Physiol Lung Cell Mol Physiol 2007 (Carcinoma, Squamous Cell...) : First, we show that EGF receptor (EGFR) and MAP kinase ERK1/2 are involved in IL-8 expression by these stimuli
Chandru et al., Gene 2007 : Pharmacological inhibitors of ERK and p38 but not JNK partly inhibited S1-P induction of IL-8 mRNA levels
Chou et al., Invest Ophthalmol Vis Sci 2007 : The MMC related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor ( SB203580 ) and an ERK inhibitor ( PD98059 )
Choi et al., J Cell Biochem 2007 : Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase dependent activation of AP-1 ... In summary, our results indicate that iron chelator induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1
Choi et al., Cell Microbiol 2007 (Duodenal Ulcer...) : At acidic pH H. pylori induced augmentation of IL-8 production involved markedly upregulated the NF-kappaB pathways and the ERK -- > c-Fos -- > AP-1 pathways
Harimaya et al., Int J Pediatr Otorhinolaryngol 2007 (Gram-Positive Bacterial Infections...) : And, inhibitors of NF-kappaB ( caffeic acid phenylethyl ester ), p38 ( SB 203580 ), or ERK1/2 ( PD 98059 ) significantly reduced IL-8 induction by the organism
Moon et al., Biochem Biophys Res Commun 2007 : DON activated ERK1/2 also mediated the production of early growth response gene 1 (EGR-1) in the epithelial cell line and EGR-1 had the positive regulatory effect on the interleukin-8 production in the human epithelial cells
Kang et al., Int Immunopharmacol 2007 : HPE induced IL-8 expression was inhibited by a selective inhibitor of JNK/SAPK, but not by inhibitors of p38 kinase or ERK
Buchholz et al., Infect Immun 2007 (Chlamydia Infections...) : C. trachomatis serovar D also induced IL-8 in an ERK dependent manner ... We concluded that IL-8 induced during infection of epithelial cells is dependent on continual activation of ERK by C. trachomatis
Subramanian et al., Inflamm Bowel Dis 2008 (Colonic Neoplasms...) : IL-8 release was mediated by extracellular regulated kinase (ERK) and p38 mitogen activated protein kinase ( MAPK ) and inhibited by mesalamine, but not hydrocortisone, at therapeutic concentrations
Yang et al., Cell Signal 2008 (MAP Kinase Signaling System) : IL-1beta stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
Ostrowska et al., Cell Mol Life Sci 2008 (Astrocytoma) : Thus, we propose that PAR-3 is able to signal autonomously to induce IL-8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses
Li et al., Cancer Sci 2008 (Neovascularization, Pathologic...) : Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Hisatsune et al., J Immunol 2008 : Inhibitors of p38 MAPK ( SB203580 ), ERK1/2 ( PD98059 ), IkappaBalpha ( ( E ) -3- ( 4-methylphenylsulfonyl ) -2-propenenitrile ), Ca ( 2+ ) entry ( SKF96365 ), and intracellular Ca ( 2+ ) channels ( dantrolene ) blocked VacA induced IL-8 production
Min et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 (MAP Kinase Signaling System...) : Furthermore, inhibition of the ERK , p38, and NF-kappaB pathways blocked SNP induced IL-8 secretion
Cheng et al., Clin Biomech (Bristol, Avon) 2008 (MAP Kinase Signaling System...) : These results suggest that ERK1/2 , JNK1/2 and p38 MAPK are all involved in the low shear stress induced IL-8 gene expression
Edling et al., Toxicol In Vitro 2008 : In accordance, the release of IL-8 was attenuated by inhibitors of the ERK- and JNK-pathways
Hong et al., Vascul Pharmacol 2009 : The present study reports that TLR-4-agonistic LPS upregulates IL-8 at the transcriptional and post-translational level in VSMCs, and that ERK1/2 , NF-kappaB, and C/EBP play major roles in the upregulation of IL-8
Watanabe et al., J Invest Dermatol 2009 (Psoriasis) : These results indicate that IL-17F may be involved in psoriasis via, in part, the activation of ERK1/2 and the induction of IL-8 in keratinocytes
Boots et al., J Biol Chem 2009 : Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation
Chandras et al., Endocrinology 2009 (MAP Kinase Signaling System) : ERK1/2 activation results in up-regulation of IL-8 expression, an effect inhibited by the CRF induced activation of PI3K/Akt
Woolson et al., Cell Signal 2009 : Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Saraiva et al., Immunity 2009 : Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38
Araki et al., J Biol Chem 2009 (Melanoma...) : Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8
Allison et al., J Immunol 2009 : Pharmacological inhibition of p38 and ERK activity significantly reduced IL-8 production in response to H. pylori, further emphasizing the importance of MAPKs in innate immune responses to the pathogen
Wang et al., FASEB J 2010 : Proteinase activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation ... Inhibition of ERK activation completely blocked PAR induced IL-8 expression, phosphorylation of p65 and HAT activity
Nomi et al., Invest Ophthalmol Vis Sci 2010 : The zymosan induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK , p38, JNK, and NF-kappaB signaling
Lee et al., Int Immunopharmacol 2010 (Dermatitis) : Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 ( an inhibitor of NF-kappaB activation ) reduced the lipopolysaccharide induced production of cytokines IL-1beta and IL-8 , and the chemokine CCL17
Sekiguchi et al., Biosci Biotechnol Biochem 2010 (Stomach Neoplasms) : However, PD98059 ( a MEK1/2 inhibitor ) dramatically down-regulated this cytokine, suggesting MEK/ERK dependent IL-8 production
Hong et al., Scand J Immunol 2010 : Through ERK inhibitor ( U0126 ) and NF-kB inhibitor ( caffeine acid phenethyl ester ) treatment, it was proven that ERK and NF-kB regulated chitinase induced IL-8 expression
Lee et al., Ann Allergy Asthma Immunol 2010 (Asthma) : Furthermore, ERK1/2 ( U0126 ) and JNK ( SP600125 ) inhibitors inhibited CraA induced IL-8 secretion by 100 % and 45 %, respectively
Bhattacharyya et al., Am J Physiol Lung Cell Mol Physiol 2011 (Cystic Fibrosis...) : However, we find that inhibition of ERK1/2 or p38 leads to suppression of the effect of JNK-2 inhibition on IL-8 mRNA stability
Zhang et al., J Cell Physiol 2012 (Carcinoma, Non-Small-Cell Lung...) : EGF stimulated IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be inhibited by EGFR inhibitor ( Erlotinib ), PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ), and ERK1/2 inhibitor ( PD98059 )
Miura et al., Infect Immun 2011 (Inflammation) : When the human leukemia cell line THP-1 was exposed to E. chaffeensis, significant upregulation of IL-8 , IL-1ß, and TNF-a mRNA and extracellular regulated kinase 2 (ERK2) activation were detected
Maza et al., Microbes Infect 2012 : Moreover, P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase ( MAPK ), c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( ERK ) 1/2 in A549 cells, and IL-8 and IL-6 secretion promoted by this fungus was dependent on activation of p38 MAPK and ERK 1/2
Lee et al., J Clin Immunol 2013 (MAP Kinase Signaling System) : The pharmacologic inhibitors of ERK , U0126 and PD98059, effectively reduced IL-8 expression and the active forms of ERK signaling molecules, as detected by anti phosphorylated p44/42 antibody
Lo et al., J Biol Chem 1998 : Requirements of focal adhesions and calcium fluxes for interleukin-1 induced ERK kinase activation and c-fos expression in fibroblasts
Lee et al., J Biol Chem 1998 (Ovarian Neoplasms) : Paclitaxel induced IL-8 promoter activation was inhibited by dominant-inhibitory mutants of JNK, p38, and the super-repressor form of IkappaBalpha, but not by dominant-inhibitory forms of ERK1
Shyamala et al., Biochemistry 1998 : Our results demonstrate the following in CHO cells stably expressing either IL-8 R1 or R2 receptors : ( a ) IL-8 activates ERK and ERK kinases ( MEK ) through R1 ... Both IL-8 and GROalpha activate ERK and MEK through R2, whereas MIP-1alpha, a beta chemokine, does not activate these kinases through either of these receptors
Marie et al., Infect Immun 1999 : By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 ( a kinase upstream of ERK1/2 ) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions