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BCL6 — RELA

Text-mined interactions from Literome

Badrichani et al., J Clin Invest 1999 : In addition, Bcl-2 or Bcl-XL inhibits activation of NF-kappaB and thus upregulation of proinflammatory genes
Bertin et al., J Biol Chem 2000 : Although its role in apoptosis remains to be determined, BCL10 likely activates NF-kappaB through the IKK complex in response to upstream stimuli
Yorke et al., Eur J Cancer 2003 (Adenocarcinoma...) : Receptor activator of NF-kappaB ( RANK ) activation induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of Bcl-xL
Chen et al., Apoptosis 2004 (Colonic Neoplasms) : Bcl-2, and to the less extent, Bcl-xL , were able to increase the activity of NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Tran et al., J Biol Chem 2005 (Astrocytoma...) : In addition, Fn14 activation induced BCL-XL and BCL-W mRNA and protein levels, and this effect was dependent upon NFkappaB transcriptional activity ... Our results suggest that NFkappaB mediated up-regulation of BCL-XL and BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Li et al., J Immunol 2005 (Lymphoma, B-Cell) : We report in this study that BCL-6 can bind to three sequence motifs in the 5 ' regulatory region of NF-kappaB1 in vitro and in vivo, and repress NF-kappaB1 transcription both in reporter assays and in lymphoma B cell lines ... BCL-6 ( -/- ) mice further confirm the biological relevance of BCL-6 dependent regulation of NF-kappaB1 because BCL-6 inactivation caused notable increase in p105/p50 proteins in several cell types ... Our results demonstrate that BCL-6 can negatively regulate NF-kappaB1 expression, thereby inhibiting NF-kappaB mediated cellular functions
Hu et al., J Clin Invest 2006 (Lymphoma, B-Cell, Marginal Zone...) : Furthermore, BCL10 and cIAP2-MALT1 synergistically activate NF-kappaB
Tao et al., Mol Cell Biol 2006 : Up-regulation of proapoptotic protein Bcl-XS and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or down-regulation of NF-kappaB and by prevention of K+ loss
Khanbolooki et al., Mol Cancer Ther 2006 (Pancreatic Neoplasms) : NF-kappaB inhibition resulted in down-regulation of BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Deeb et al., J Pharmacol Exp Ther 2007 (Prostatic Neoplasms) : Because expression of antiapoptotic Bcl-2, Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is regulated by NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
Kunnumakkara et al., Cancer Res 2007 (Neovascularization, Pathologic...) : In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ), NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Takase et al., Kidney Int 2008 (Chronic Disease...) : Inhibition of NF-kappaB dependent Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008 (Carcinoma, Squamous Cell...) : A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Perez-Rosado et al., J Pathol 2008 (Lymphoma, Large B-Cell, Diffuse) : BCL6 represses NFkappaB activity in diffuse large B-cell lymphomas
Aimbire et al., Int Immunopharmacol 2008 (Inflammation) : LLLT and an inhibitor of NF-kappaB nuclear translocation ( BMS 205820 ) attenuated the mRNA levels of Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009 (Adenocarcinoma...) : NFkappaB DNA binding activity and NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes
Banerjee et al., Cancer Res 2009 (Pancreatic Neoplasms) : Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced activation of NF-kappaB and its downstream genes ( Bcl-xL , XIAP, cIAP, and survivin )
Jinawath et al., PloS one 2010 (Ovarian Neoplasms) : Combined ectopic expression of RELA and STAT5B enhanced Bcl-xL promoter activity while treatment with BMS-345541 and Dasatinib decreased it
Zhang et al., Mol Cell Biol 1994 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In contrast to I kappa B alpha ( MAD3 ), BCL3 does not cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50