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HSPG2 — PI3

Text-mined interactions from Literome

Liu et al., J Leukoc Biol 2003 : Wortmannin, the PI-3K inhibitor, at the concentration sufficient to inhibit PI-3K activity, can only partially inhibit Ca ( 2+ ) release from the internal store, indicating a partial regulation of PLC signaling by PI-3K and the existence of two pathways initiated by different PLC subfamilies
Rodríguez et al., Endocrinology 2004 : PI3-kinase products could induce PLC-gamma activation, whose hydrolytic activity could activate the DAG dependent isoforms PKC alpha, theta, and epsilon
Marjoram et al., J Biol Chem 2009 : The enhanced alpha ( 2 ) beta ( 1 ) -mediated platelet adhesion is controlled by phospholipase C (PLC) , but is not dependent on granule secretion, activation of alpha(IIb)beta(3) integrin, or on phosphoinositol-3 kinase (PI3K) activity
Valdés et al., J Cell Physiol 2013 (Calcium Signaling) : This response was completely blocked when myoblasts were incubated with LY294002 or transfected with the dominant negative p110 gamma, suggesting a fundamental role of phosphatidylinositol 3-kinase (PI3K) in PLC? activation
Bae et al., J Biol Chem 1998 : Furthermore, the expression of an activated catalytic subunit of PI 3-kinase in COS-7 cells resulted in an increase in inositol phosphate formation, whereas platelet derived growth factor induced PLC activation in NIH 3T3 cells was markedly inhibited by the specific PI 3-kinase inhibitor LY294002