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IFNG — IRF6

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Nomura et al., Toxicol Lett 1998 (Ischemic Attack, Transient) : LPS caused intranuclear translocation of NF-kappaB, and IFNgamma induced phosphorylation of Jak2 and Stat1, followed by the translocation of Stat1 into the nucleus
Jin et al., Methods 1998 (Inflammation) : Interferon-gamma (IFN-gamma) , which corrects the defective LPS response in Lps ( d ) macrophages, suppressed the LPS induced expression of SLPI and restored LPS response to SLPI overexpressing macrophages
Smith et al., Immunopharmacology 1999 (Endotoxemia) : Indeed, the protective effects of exogenously administered IL-10 against murine endotoxin lethality have been shown to correlate with its ability to inhibit the LPS induced production of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)
Schlaak et al., J Hepatol 1999 (Hepatitis B) : With regard to antigen unrelated stimulation, significantly lower amounts of LPS induced IFN-gamma production and alpha-CD3+28 induced proliferative responses, but higher amounts of LPS induced IL-10 were observed in group 3
Nakashima et al., J Am Soc Nephrol 1999 : TNF-alpha or LPS alone did not induce nitrite production, but with IFN-gamma these compounds did induce nitrite production
Kano et al., Biochem Biophys Res Commun 1999 : Taken together, IRF-1 mediates IFN-gamma signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis
Cowdery et al., J Immunol 1999 : Even though IFN-gamma augmented LPS-driven p40 promoter activity in RAW 264 cells, the combination of IFN-gamma and LPS induced less p40 mRNA or protein secretion than the combination of IFN-gamma and CpG DNA
Ranta et al., Crit Care Med 1999 : IFN-gamma , IL-1beta, or LPS alone did not induce TNF-alpha production, whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent, and the production could be further increased with LPS
Arena et al., New Microbiol 1999 : Furthermore, HHV-6 infection inhibited IFN gamma release induced by LPS in PBMC
Horváth et al., Immunol Lett 1999 : We found, that histamine inhibited the LPS induced transcription of IFNgamma gene and biosynthesis of IFNgamma protein in PMBC and also in CD19 depleted cell populations
Huang et al., Infect Immun 1999 : In the absence of IL-10, B. abortus LPS induced strong IFN-gamma responses, but IL-12 p70 levels were still undetectable from BALB/c spleen cells
Green et al., Leukemia 1999 (Chromosome Deletion...) : Unexpectedly, all primary acute promyelocytic leukemia ( APL ) samples lacked IRF-1 protein and most exhibited accelerated exon skipping ; furthermore, IRF-1 could not be induced by IFNgamma or all-trans retinoic acid ( ATRA ) which both induce IRF-1 in the NB4 APL cell line
Tominaga et al., J Leukoc Biol 1999 : Anti-IL-12 antibody, which suppressed the LPS induced IFN-gamma production, also suppressed the augmented NO production, as did anti-IFN-gamma antibody
Santucci et al., Hepatology 2000 (Drug-Induced Liver Injury) : In addition, galectin-1 almost completely prevented the Con A-induced increase in plasma TNF-alpha and IFN-gamma, an effect that was, at least in part, independent on the elimination of activated T helper cells, because galectin-1 prevented lipopolysaccharide (LPS) induced release of TNF-alpha and IFN-gamma also from macrophages in vitro, without affecting their viability
Fehniger et al., J Immunol 2000 (Shwartzman Phenomenon) : LPS stimulation of SCID mouse splenocytes resulted in measurable IFN-gamma production, which was reduced when IL-15 was neutralized or IL-2/15Rbeta was blocked ... Collectively, these data provide the first in vivo evidence that IL-15 participates in LPS induced innate immune IFN-gamma production and significantly contributes to the lethal Shwartzman reaction
Heriot et al., Br J Cancer 2000 (Colorectal Neoplasms) : The aim of this study was to assess monocyte/macrophage function, as defined by lipopolysaccharide (LPS) induced production of tumour necrosis factor (TNF)-alpha, interleukin (IL)-10 and interferon (IFN)-gamma by stimulated whole blood cultures in patients with colorectal carcinoma before and after surgical resection ... LPS induced production of TNF-alpha and of IFN-gamma was reduced in patients with colorectal carcinoma compared to controls ( TNF-alpha, 11,269 pg/ml(-1) ¿12,598¿ ; IFN-gamma, 0.00 pg/ml(-1) ¿226¿ ; median ¿IQR¿ ) ( TNF-alpha, 20,576 pg/m ( -1 ) ¿11,637¿, P < 0.0001 ; IFN-gamma, 1,048 ¿2,428¿, P = 0.0051, Mann-Whitney U-test )
Faggioni et al., Am J Pathol 2000 (Disease Susceptibility...) : In contrast, LPS induced lower levels of interferon-gamma and no differences in interleukin-1beta in fasted compared to fed animals ; leptin had no effect on those cytokines
Xing et al., Immunology 2000 (Marek Disease) : Addition of LPS and/or rChIFN-gamma resulted in the up-regulation of mRNA for iNOS, IL-1beta and IL-6, while IFN-gamma was up-regulated by LPS alone
Hochholzer et al., Infect Immun 2000 (Shock) : LPS induced IFN-gamma production was abrogated, yet induction of IL-12 and TNF was not affected ... These results imply that IL-18 plays an important role in induction of IFN-gamma and lethality in response to LPS
Granger et al., Biochim Biophys Acta 2000 : Whilst the expression of JunD was not affected by any of the mediators, the mRNA levels of c-fos and JunB were induced by LPS , IL-6, IFN-gamma, PDGF and TNF-alpha, and that of c-jun by LPS, IFN-gamma , PDGF and TNF-alpha
Hessle et al., Scand J Immunol 2000 : Purified lipopolysaccharide (LPS) induced neither proliferation nor IFN-gamma production
Lauw et al., J Immunol 2000 (Endotoxemia...) : IL-10 treatment, particularly when administered after LPS, enhanced LPS induced IFN-gamma release, as well as the release of the IFN-gamma dependent chemokines IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma, while inhibiting or not influencing the production of IFN-gamma inducing cytokines
Haskó et al., Shock 2000 (Inflammation...) : In spleen cell suspensions, spermine suppressed the release of IFN-gamma induced either by LPS or anti-CD3 antibody
Biswas et al., FEMS Immunol Med Microbiol 2000 : The nitrite release of LPS was enhanced significantly by lower concentrations of porin, whereas the effect of IFN-gamma was enhanced by porin at higher concentrations
Urbanik-Sypniewska et al., Immunobiology 2000 : Weak lethality of LPS from Mesorhizobium correlated with low capacity of this LPS to induce TNF-alpha, IL-1beta, IL-6 and IFN-gamma both in vivo and in vitro in murine splenocytes
Feili-Hariri et al., Clin Immunol 2001 : NOD GM + IL-4 DC produced lower amounts of IL-12 p70 following CD40 ligation or LPS stimulation in the presence of IFN-gamma than DC from other strains, although similar levels of IL-6 and NO were produced by all strains
Dinges et al., Infect Immun 2001 (Hypersensitivity) : Cs pretreatment also completely inhibited the known capacity of TSST-1 to amplify LPS induced levels of IFN-gamma in serum ... Cs given after TSST-1 also did not inhibit enhancement of LPS induced serum TNF-alpha by TSST-1 but inhibited the enhancement effect of TSST-1 on LPS induced serum IFN-gamma by 50 %
Parmely et al., Infect Immun 2001 (Escherichia coli Infections) : Glutathione depletion completely inhibited the IFN-gamma response to LPS , but only partially inhibited IFN-gamma production in infected mice
Nicoletti et al., Antimicrob Agents Chemother 2001 (Disease Models, Animal...) : The treatment also lowered LPS induced levels of TNF-alpha and IFN-gamma in the blood
Habu et al., J Immunol 2001 (Dermatitis, Atopic...) : The low IFN-gamma response to staphylococcal enterotoxin B was correlated to the lack of regular Vbeta8 ( + ) T cells and Vbeta8 ( + ) NK T cells, and the low IFN-gamma response to LPS was correlated to an impaired IL-18 production of macrophages
Park et al., Int J Lepr Other Mycobact Dis 2000 : These data indicate a pivotal role for IFN-gamma and IFN-beta for the production of LPS and LAM initiated NO in peritoneal macrophages from low-responder ( C3H/HeJ ) mice
He et al., J Nutr 2001 (Body Weight) : In contrast, dietary caffeine significantly suppressed LPS induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration
Samardzic et al., Clin Exp Immunol 2001 : The effect of phosphodiesterase inhibiting anti-inflammatory drug pentoxifylline ( PTX ) on LPS induced IL-18 synthesis and IL-18 mediated IFN-gamma-induction were investigated
Stober et al., J Immunol 2001 : The presence of LPS during the stimulation of DC with IL-18 plus endogenous ( CD40 ligation ) or exogenous IL-12 did not affect their IFN-gamma release
Varma et al., Infect Immun 2001 : However, the cellular mediators regulating LPS induced production of IFN-gamma in normal mice and the effect of LPS tolerance on these mediators has not been well characterized ... Assessment of important IFN-gamma regulating factors showed that interleukin-12 (IL-12) and costimulatory signals provided by IL-15, IL-18, and CD86 are largely responsible for LPS induced IFN-gamma expression in control mice ... This study also better defines the factors that mediate LPS induced IFN-gamma production in normal mice
Boneberg et al., J Pharmacol Exp Ther 2001 : However, the lipopolysaccharide (LPS) induced release of tumor necrosis factor (TNF)-alpha was increased, and the secretion of interleukin (IL)-10 was reduced by Lektinol at a mistletoe lectin-1 (ML-1) concentration of 0.5 to 5 ng/ml, whereas the LPS induced secretion of IL-1 beta, IL-6, IL-12, and interferon-gamma was not affected
Panerai et al., Diabetologia 2001 (Diabetes Mellitus, Type 1...) : Anti-CD3 and/or lipopolysaccharide (LPS) induced blood levels of interferon (IFN)-gamma , interleukin (IL)-4, IL-10, IL-12 and tumour necrosis factor (TNF)-alpha were measured by ELISA in 10 week-old female NOD mice treated for 6 consecutive weeks with either MFP14 or PBS
Faggioni et al., J Immunol 2001 (Granuloma...) : Given 10 min before LPS challenge to mice primed 12 days in advance with heat killed Propionibacterium acnes, IL-18BP-Fc prevents LPS induced liver damage and IFN-gamma and Fas ligand expression
Sherwood et al., Clin Sci (Lond) 2001 : Glucan treatment potentiated LPS induced IFN-gamma expression in control mice ... The induction of LPS tolerance resulted in marked suppression of LPS induced IFN-gamma production
Lochner et al., J Immunol Methods 2002 : In vivo, LPS induced IFN-gamma production was reduced by 60-85 % following a single administration of Mabs SK113AE-4 or SK721-2
Chung et al., Eur J Immunol 2002 : Furthermore, in macrophage cells, transcripts for TREM-3 were up-regulated by LPS , but were down-regulated by IFN-gamma
Jarosinski et al., J Neuroimmunol 2002 : MHC class I gene promoter activity in astrocytes was controlled entirely through a single enhancer, the MHC-IRF-E , to which IRF-1 bound in response to IFN-gamma in wild type but not in IRF-1 ( -/- ) mouse astrocytes
Leoni et al., Proc Natl Acad Sci U S A 2002 : Steady-state mRNA levels for LPS induced TNF-alpha and IFN-gamma in peripheral blood mononuclear cells were markedly decreased, whereas IL-8 and IL-1-beta mRNA levels were unaffected
Fernandez et al., Eur Cytokine Netw 2002 : Conversely, in the presence of LPS , resting bulk NK cells interacting with DC acquire CD25 and CD69 surface expression, produce high levels of IFN-gamma and lyse DAUDI cells
Moré et al., Scand J Immunol 2002 : LPS induced IFN-gamma in T cell cultures even when the number of antigenic major histocompatibility complex ( MHC ) class-I complexes was too small to stimulate the T cells
Varma et al., Clin Diagn Lab Immunol 2002 : However, the specific cell types that produce IFN-gamma in response to LPS and the cellular factors that regulate LPS induced IFN-gamma production have not been fully determined ... The present studies were undertaken to characterize the cell populations that produce IFN-gamma after LPS challenge in the spleens of mice and to determine the regulatory factors that modulate LPS induced production of IFN-gamma ... IL-10 is a major inhibitor of LPS induced IFN-gamma production ... Unlike intact heat killed gram negative and gram positive bacteria, the class II major histocompatibility complex did not play a functional role in LPS induced IFN-gamma production ... These data demonstrate that NK cells and NKT cells are the most abundant IFN-gamma producing cells in the mouse spleen after LPS challenge and that IL-10 and IL-12 are key functional regulators of LPS induced IFN-gamma production
Kaisho et al., Int Immunol 2002 : In response to LPS , wild-type DC could enhance their ability to induce IFN-gamma production in allogeneic mixed lymphocyte reaction ( alloMLR )
Ami et al., J Immunol 2002 (Bacterial Infections...) : However, IL-18 injections into mice on alternate days beginning 1 day after burn injury strongly up-regulated LPS induced serum IFN-gamma levels and IFN-gamma production from liver and spleen MNC of mice 7 days after burn injury and down-regulated serum IL-10
Breidthardt et al., Immunobiology 2002 (Hyperprolactinemia) : Our results indicate that prolactin can upregulate IFN-gamma secretion from immune cells in whole blood cell cultures in response to both PHA or LPS
Walz et al., Horm Metab Res 2002 (Diabetes Mellitus, Type 1) : IL-4-Ig was found to downregulate LPS induced IFN-gamma and TNF-alpha production
Lettinga et al., Thorax 2003 (Legionnaires' Disease) : Patients released less IFN-gamma than controls in response to stimulation with LPS ( mean ( SE ) 393 ( 58 ) pg/ml v 914 ( 178 ) pg/ml ; p=0.001 ) and IL-12 ( 96 ( 14 ) pg/ml v 177 ( 41 ) pg/ml ; p=0.058 )
Maruyama et al., J Immunol 2003 : While IFN-gamma must be present for IL-12 p40 gene induction, the p35 gene is strongly induced by LPS , even in the absence of IFN-gamma, and therefore the induction of the p35 gene is IRF-1 independent
Kambayashi et al., J Immunol 2003 : LPS induced IFN-gamma production by CD8 ( + ) T cells was MHC class I independent and was restricted to CD44 ( high ) ( memory phenotype ) cells
Amakawa et al., Exp Lung Res 2003 : Lipopolysaccharide (LPS)- or IFN-gamma induced TNF-alpha and IL-6 production by murine AMs were suppressed by DEP in a dose dependent manner ( P < .05 )
Bang et al., J Pharmacol Exp Ther 2003 (Drug-Induced Liver Injury...) : NK-1R blockade clearly inhibited GalN/LPS induced production of TNFalpha and IFNgamma , whereas synthesis of the hepatoprotective cytokines IL-6 and IL-10 was increased
Suzuki et al., Infect Immun 2003 : In these cells, IFN-gamma does not induce LPS responsiveness
Yoshikawa et al., Eur J Immunol 2003 : Moreover, the activation of mast cells by LPS is enhanced in the presence of IFN-gamma , which up-regulates the expression of cell surface TLR4
Nold et al., Biochem Pharmacol 2003 : Notably, IL-18 BPa : Fc ( 200 ng/mL ) further reinforced dexamethasone ( 5 nM ) - or mycophenolic acid ( 2 microM ) -mediated reduction of LPS/IL-12 induced IFNgamma production by an additional 50.5 or 49.9 %, respectively
Leshchinsky et al., Poult Sci 2003 : The LPS caused an increase in IL-1beta, MGF, and IFNgamma expression at all VE concentrations and had no effect on IL-2 and TGFbeta mRNA expression
Matsuura et al., Eur J Biochem 2003 : In the PEC culture, LPS induced both IFN-gamma production and activation of IFN response factor-1, which leads to the gene expression of inducible NO synthase, but neither was induced in the culture of RAW264.7 cells
Kohut et al., J Am Coll Nutr 2003 : LPS induced production of IL-1beta, and PHA induced IL-2, IL-4, IL-10, or IFN-gamma production was not altered by the supplement
Min et al., Mol Cells 2003 : LPS , particularly in the presence of IFN-gamma , induced P388D1 cells to secrete active TGF-beta1
Shin et al., Immunopharmacol Immunotoxicol 2003 (Fatigue Syndrome, Chronic) : Bojungikki-tang showed a slightly lower inhibitory effect of LPS induced Interferon (IFN)-gamma production
Shaklee et al., Cytokine 2004 : Mice pretreated with G-CSF for 7 days before LPS had lower serum levels of LPS induced interferon-gamma (IFN-gamma) and higher levels of interleukin (IL)-6 and IL-10 than controls
Cui et al., Am J Physiol Regul Integr Comp Physiol 2004 (Shock) : In additional experiments, although 24-h infusions of LeTx and Escherichia coli LPS produced similar mortality rates ( 54 and 56 %, respectively ) and times to death ( 13.2 +/- 0.8 vs. 11.0 +/- 1.7 h, respectively ) compared with controls, only LPS reduced circulating leukocytes, platelets, and IL-2 levels and increased TNF-alpha, IL-1 alpha and -1 beta, IL-6, IL-10, interferon-gamma , granulocyte macrophage-colony stimulating factor, RANTES, migratory inhibitory protein-1 alpha, -2, and -3, and monocyte chemotactic protein-1, as well as nitrate/nitrite levels ( all P < or = 0.05 for the effects of LPS )
Gould et al., J Immunol 2004 : Distinct modulatory effects of LPS and CpG on IL-18 dependent IFN-gamma synthesis
Moutabarrik et al., Lymphokine Cytokine Res 1992 : Furthermore, we report that LPS induced IFN-gamma production in monocyte culture
Shin et al., J Ethnopharmacol 2004 (Fatigue Syndrome, Chronic) : However, LPS induced interferon-gamma production was significantly increased by KBT ( 0.01 mg/ml )
Schmolz et al., Exp Gerontol 2004 : LPS induced production of three different cytokines, interferon gamma (IFNgamma), interleukin-6 (IL-6), and interleukin-10 (IL-10)
Sharma et al., Immunol Lett 2004 : It is observed that rLcrV and rYopB inhibited the LPS induced expression of TNF-alpha, IFN-gamma , KC, IP-10, and IL-12 in macrophages
Yajima et al., Infect Immun 2004 : Liver T cells from BCG primed IL-15 Tg mice produced IFN-gamma in vitro in response to LPS , which was inhibited by the addition of anti-IL-12 monoclonal antibody ( MAb )
Kamezaki et al., Int Immunol 2004 (MAP Kinase Signaling System...) : Interestingly, the induction of both IFN-beta and IFN-gamma by LPS was severely reduced in Tyk2-deficient mice
Fagerås Böttcher et al., J Allergy Clin Immunol 2004 (Asthma...) : LPS induced IL-12 ( p70 ), IL-10, and IFN-gamma responses of PBMCs from 69 of the children were analyzed by means of ELISA
Chang et al., Exp Mol Med 2004 : Moreover, LPS/ IFN-gamma stimulated RAW264.7 cells, which produce endogenous NO, expressed lower levels of iNOS, IL-1beta, IL-6 and TNF-alpha mRNAs, without changes in their mRNA half-lives, than those in the presence of the iNOS inhibitor NG-monomethyl-L-arginine
Tachibana et al., J Leukoc Biol 1992 : Amo phi s incubated with 10 ( 3 ) ng/ml LPS produced 50 times more TNF than RPm phi s and 5 times more than TGPm phi s, and LPS alone induced maximum TNF production by Am phi s. Stimulated cell supernatant or recombinant IFN-gamma alone did not induce TNF production
Esquifino et al., Endocrine 2004 : CD4+/CD8+ ratio, IFN-gamma release and Concanavalin A ( Con A ) and lipopolysaccharide (LPS) responses correlated significantly with plasma prolactin or GH levels while T/B ratio correlated with plasma prolactin levels only
Sugiyama et al., Microbiol Immunol 2004 : 2-AP also reduced the expression of IFN-beta and IFN-inducible genes, such as IFN-gamma-inducible protein ( IP ) -10 and immune-responsive gene (IRG)-1, and the inducible type of NO synthase (iNOS) mRNA in response to LPS
Sheikh et al., Cardiovasc Res 2005 (Arteriosclerosis) : Northern blotting showed that lysoPC transiently and dose-dependently inhibited the IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48, interferon regulatory factor-1 and guanidine binding protein-1
Shen et al., J Pharm Pharmacol 2005 (Hyperglycemia...) : LPS induced increases in plasma interleukin-1beta (IL-beta), IL-6, interferon-gamma (IFN-gamma) , tumour necrosis factor-alpha (TNF-alpha) and blood glucose levels were significantly inhibited by eugenosedin-A ( 1 mg kg ( -1 ), i. v. )
Tournier et al., J Immunol 2005 : Furthermore, ET inhibits in vivo IL-12p70 and IFN-gamma secretion induced by LPS
Osuchowski et al., Food Chem Toxicol 2005 (Body Weight) : FB ( 1 ) decreased the LPS induced brain expression of IFNgamma and IL-1beta, whereas the expression of IL-6 and IL-12 was augmented
Matalka et al., Neuro Endocrinol Lett 2005 : LPS increased significantly the production of TNF-alpha, IFN-gamma , and IL-10 from liver ( 521 %, 123 %, 72 % : p < 0.01, 0.04, 0.04 ), brain ( 470 %, 122 %, 280 % : p < 0.01, 0.03, 0.01 ), peritoneal lavage ( p < 0.001 ) and blood ( p < 0.001 )
Bogle et al., Biochem J 1992 : Bacterial lipopolysaccharide (LPS) induced a dose- and time dependent stimulation of nitrite production, which was further increased in the presence of interferon-gamma
Kirkpatrick et al., J Infect Dis 2005 (Typhoid Fever) : Immunogenicity data included Salmonella Typhi lipopolysaccharide (LPS)-specific immunoglobulin (Ig) A antibody secreting cells ( enzyme linked immunospot [ ELISPOT ] assay ), IgG serologic responses to Salmonella Typhi LPS , lymphocyte proliferation, and interferon (IFN)- gamma production
Tsukada et al., Int Immunol 2005 : The CD8 DCs secrete a large amount of IFN-gamma , IL-12 and B lymphocyte stimulator/B cell activation factor of the tumor necrosis factor family in response to LPS and CpG stimulation
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : IFN-gamma enhances LPS for the induction of MDC and IP-10 through up-regulation of TLR-4, and the signal pathways of NF-kappaB and AP-1/ERK1/2
Choi et al., J Neurosci Res 2005 (Alcohol-Induced Disorders, Nervous System...) : Lipopolysaccharide (LPS), gangliosides, and interferon (IFN)-gamma induced the inflammatory activation of glia, which was differentially influenced by ethanol : 1 ) ethanol inhibited LPS- or gangliosides induced, but not IFNgamma induced, glial activation as demonstrated by the production of nitric oxide and the expression of inflammatory genes such as interleukin-1beta, tumor necrosis factor-alpha, IP-10, and CD86 ; 2 ) nuclear factor (NF)-kappaB or JAK/STAT1 pathway was necessary for LPS- or IFNgamma induced glial activation, respectively ; 3 ) ethanol inhibited LPS induced NF-kappaB activation ; and 4 ) ethanol did not significantly affect IFNgamma induced STAT1/IRF-1 activation
Sheu et al., Food Chem Toxicol 2006 (Glomerulonephritis) : Exogenous CLA dose-dependently diminished iNOS mRNA and protein expression as well as NO production in lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) stimulated SV-40 transformed mouse mesangial cells
Varma et al., Infect Immun 2005 : LPS primed wild-type mice exhibited significant suppression of LPS induced IFN-gamma and IL-12 but increased IL-10 production in blood and spleen compared to levels exhibited by saline primed wild-type mice
Yun et al., Int Immunopharmacol 2005 : RT-PCR analysis showed that LPS activated IFN-gamma expression gradually declined by CHL treatment in a dose dependent manner while mRNA production of TNF-alpha, IL-2, and FasL was not changed
Shi et al., Int J Biochem Cell Biol 2006 (Breast Neoplasms...) : Both treatments induced USF-1 and IRF binding complexes to promoter IV but only IFNgamma induced the binding of 435-Lung2 nuclear proteins to an ARE-1 site at the promoter III
Matsumoto et al., J Hepatol 2006 : Notably, depletion of B220+ cells from liver MNCs ( but not from spleen MNCs ) greatly decreased LPS induced IFN-gamma production
Corsini et al., J Leukoc Biol 2006 : A decrease in LPS induced tumor necrosis factor alpha (TNF-alpha), increased PHA induced interleukin-10 (IL-10) release, and similar PHA induced interferon-gamma production were observed in elderly subjects compared with young volunteers
Fan et al., Frontiers in bioscience : a journal and virtual library 2006 (Gram-Negative Bacterial Infections...) : Both LPS and SA significantly ( p < 0.05 ) induced cytokine production IL-6 > TNF alpha > IL-1 beta > GM-CSF > IL-10 > IFN gamma
Chan et al., Phytother Res 2006 (MAP Kinase Signaling System) : In terms of cytokine production, treatment of CKBM alone did not trigger the release of IL-1beta and IFNgamma, but it suppressed the LPS induced IFNgamma production from both Sup-T1 cells and Ramos cells
Yao et al., J Immunol 2006 (MAP Kinase Signaling System) : In macrophages, LPS inhibited IFN-gamma-inducible CIITA and MHC class II expression without affecting expression of IFN regulatory factor-1 and MHC class I. Blocking ERK and p38 by MAPK inhibitors not only rescued LPS mediated inhibition, but also augmented IFN-gamma induction of CIITA
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Duramad et al., J Appl Toxicol 2006 : Human blood cultures were treated with CPF/CPO/TCP ( 1-1000 microg ml(-1) ) and LPS ( 1.5-2.5 microg ml(-1) ) or Der p1 ( 200 AU ml(-1) ) and supernatants were collected at 48 h. Pesticides CPF, CPO and TCP did not induce cytokine expression in vitro, while LPS and Der p1 induced IFN-gamma and IL-4 expression, respectively ... While CPO increased LPS dependent induction of IFN-gamma , CPO treatment did not alter Der p1 induction of IL-4
Velayudham et al., J Hepatol 2006 (Granuloma...) : Selective priming through TLR9 but not TLR2 induced granulomas, elevated serum ALT, and sensitized C57BL6 mice to increased LPS induced serum IL-6, IL-12 and IFNgamma levels
Di Marzio et al., J Gen Virol 1990 : These results indicate that ( i ) various stimuli can induce IFN-beta production by PM, ( ii ) Lpsd PM spontaneously transcribe low levels of IFN-beta mRNA, even though they can not transfer an antiviral state, ( iii ) different stimuli, but not LPS , induce a normal IFN response in Lpsd PM, ( iv ) IFN-gamma increases the accumulation of IFN-beta mRNA in Lpsd PM by post-transcriptional mechanisms and ( v ) IFN-gamma may act synergistically with endogenous IFN-beta in inducing a potent antiviral state to VSV in PM
Maruyama et al., J Bone Miner Metab 2006 : Lipopolysaccharide (LPS) can induce tolerance in macrophages, whereas interferon (IFN)-gamma can activate macrophages to produce cytokines, exert bactericidal effects, and present antigens
Renckens et al., J Immunol 2006 : LPS induced IFN-gamma release in mice deficient for uPA, the uPA receptor, or tPA was not different from IFN-gamma release in LPS treated Wt mice
Ramana et al., Cytokine 2006 : Inhibition of AR by three distinct AR inhibitors sorbinil, tolrestat or zopolrestat suppressed the LPS induced production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma , and chemokine MCP-1 in murine peritoneal macrophages
Spertini et al., J Immunol 1991 : Expression of the LAM-1 ligand by endothelium was optimally induced by LPS and the proinflammatory cytokines TNF-alpha and IL-1 beta, whereas IFN-gamma and IL-4 induced lower levels of expression
Inoue et al., J Appl Toxicol 2007 : LPS significantly increased the protein levels of IFN-gamma , IL-2 and IL-10
Flores et al., J Immunol 2007 : Our analysis revealed that both LPS and CpG induced IL-10 and IL-12 production but that the presence of IFN-gamma , in a dose dependent manner, suppressed the production of IL-10 while enhancing that of IL-12
Landmann et al., J Cell Biochem 1991 : LPS at a low dose increased CD14, at a high dose it produced a variable decrease of CD14 in PBL, which was probably due to LPS induced IFNg secretion
Nagarajan et al., J Immunol 2007 : In this study, we demonstrate that mouse NKT cells are activated in response to Escherichia coli LPS , and produce IFN-gamma , but not IL-4, although activation through their TCR typically induces both IL-4 and IFN-gamma production ... LPS induced IFN-gamma production by NKT cells does not require CD1d mediated presentation of an endogenous Ag and exposure to a combination of IL-12 and IL-18 is sufficient to activate them
Buckley et al., Mol Cancer Res 2007 : Using an Affymetrix U95A microarray, IRF-7 was identified as a BRCA1 transcriptional target and was also shown to be synergistically up-regulated by BRCA1 specifically in the presence of IFN-gamma , coincident with the synergistic induction of apoptosis
Fontana et al., Rejuvenation Res 2007 (Obesity, Morbid...) : At baseline, LPS stimulated MCP-1 production and PMAI stimulated IFNgamma production by PBMCs were 93.6 % +/- 4.9 % and 88.8 % +/- 9.6 % lower, respectively, in obese than in lean subjects ( p < 0.03 ) ... Weight loss completely restored LPS stimulated MCP-1 production and PMA+I stimulated IFNgamma production in obese subjects to normal
Moriya et al., Ann Surg 2007 (Critical Illness...) : As compared with enterally fed mice, cytokine production ( TNF-alpha, IFN-gamma , and IL-10 ) by hepatic MNCs in response to LPS was impaired in parenterally fed mice in association with blunted phosphorylation of ERK1/2, a MAPK
Srinivasan et al., J Immunol 2007 (Salmonella Infections, Animal) : Furthermore, innate T cell production of IFN-gamma in response to bacterial lysate or LPS was Ag independent and could be induced in Listeria infected mice and in the absence of MHC class II expression
Tsuboi et al., Clin Immunol 2007 (Shwartzman Phenomenon) : The fact that Gal-9 does not suppress LPS induced TNF-alpha, IFN-gamma and IL-12 production in neutropenic mice, and that it does not protect those mice from the Shwartzman reaction, confirms the involvement of PMN in regulation
Simon et al., Br J Dermatol 2007 (Dermatitis, Atopic) : Results Upon stimulation with LPS , PBMC from AD patients produced significantly higher amounts of tumour necrosis factor-alpha, interferon-gamma and interleukin (IL)-10 compared with control PBMC
Sohn et al., Vet Res 2007 : Bovine PMN were shown to secrete TNF-alpha, IL-1beta, IL-12, IL-8 and IFN-gamma in response to LPS
Le-Thi-Phuong et al., Int Immunol 2007 (Arterivirus Infections...) : In sharp contrast with other viral infections, IFN-alpha/beta diminished IFN-gamma production and the resulting increased response to LPS in LDV infected animals
Langhorst et al., Psychoneuroendocrinology 2007 (Colitis, Ulcerative) : Significant but comparable public speaking stress induced increases in LPS stimulated TNF-alpha and IL-10, as well as in CD2/CD28 stimulated IFN-gamma were observed in both groups
Clarke et al., J Biol Chem 2008 (Inflammation) : The effect of atorvastatin on the LPS induced increases in IFNgamma and IL-1beta was absent in tissue prepared from IL-4 ( -/- ) mice
Schedel et al., Am J Respir Crit Care Med 2008 (Genetic Predisposition to Disease...) : Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding, IRF-1 gene expression, and IFN-gamma regulation
Ozawa et al., Mod Rheumatol 2007 (Arthritis, Rheumatoid...) : In addition, we found that nuclear factor (NF)-kappaB inhibitor IMD-0354, dexamethasone, and interferon (IFN)-gamma inhibited the LPS- and poly-IC induced TSLP production in RA and OA synovial fibroblasts
Velickovic et al., Int Arch Allergy Immunol 2008 (Hypersensitivity) : Moreover, LPS increased the levels of rFel d 1-stimulated IFNgamma in cultures from cat negative subjects, IL-5 from cat positive subjects and IL-10 from both groups
Alvarado et al., Cytokine 2008 : In the presence of LPS , ECM bound IFN-gamma , but not soluble IFN-gamma, reduced the enterocyte MT1-MMP protein expression
Hung et al., Eur Respir J 2008 : In the present study, the effects of formoterol and salmeterol on lipopolysaccharide (LPS) induced expression of the Th2 related chemokine macrophage derived chemokine ( MDC ; CCL22 ) and the Th1 related chemokine interferon-gamma-inducible protein ( IP)-10 (CXCL10 ) were investigated in a monocytic cell line, THP-1, and in human primary monocytes
Jarry et al., J Clin Invest 2008 : Finally, adding a commensal bacteria strain to mucosa explant cultures depleted of both IL-10 and LPS reproduced the ability of endogenous LPS to induce IFN-gamma secretion
Calderon et al., Int J Oncol 2008 (Neoplasms) : Combinations of LPS and IFN-gamma did not alter the latter result, suggesting that IFN-gamma enhances LPS-induction of iNOS through a pathway other than activation of PKC
Zelnickova et al., Nitric Oxide 2008 : NO production was induced by lipopolysaccharide (LPS) or by phorbol 12-myristate 13-acetate ( PMA ) with ionomycin or recombinant interferon gamma ( rIFN-gamma ) and was assessed by Griess reaction
Chochi et al., Clin Cancer Res 2008 (Helicobacter Infections...) : H. pylori LPS induced neither interleukin-12 nor IFN-gamma production by MNC, although E. coli LPS did induce production of both significantly
Kasahara et al., J Immunol 2008 (Acute Disease...) : However, exposure to acrolein after LPS instillation markedly diminished the LPS induced production of several inflammatory cytokines, specifically TNF-alpha, IL-12, and the Th1 cytokine IFN-gamma , which was associated with reduction in NF-kappaB activation
Yu et al., Mol Cell Biochem 2008 : Although LPS- and PGN induced cytokine secretions were decreased greatly by MyD88 downregulation, IFN-gamma induced protein-10 ( IP10 ) and IFNbeta expression were enhanced by LPS irrespective of the downregulation of MyD88
Reale et al., Brain Behav Immun 2009 (Parkinson Disease) : Basal and LPS induced levels of MCP-1, RANTES, MIP-1alpha, IL-8, IFNgamma , IL-1beta and TNFalpha were significantly higher in PD patients than in HC subjects ( p < 0.001 ), as determined by RT-PCR and Elisa methods
Dai et al., Blood 2008 : Suppression of LPS induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen regulated microRNAs : a novel mechanism of immune modulation ... In this study, we investigated the potential role of miRNAs in estrogen mediated regulation of innate immune responses, as indicated by up-regulation of lipopolysaccharide (LPS) induced interferon-gamma (IFNgamma) , inducible nitric oxide synthase (iNOS), and nitric oxide in splenic lymphocytes from estrogen treated mice ... Increasing the activity of miR-146a significantly inhibited LPS induced IFNgamma and iNOS expression in mouse splenic lymphocytes ... miR-223, which is markedly enhanced by estrogen, regulates LPS induced IFNgamma , but not iNOS or nitric oxide in splenic lymphocytes ... Inhibition of miR-223 activity decreased LPS induced IFNgamma in splenic lymphocytes from estrogen treated mice
Wang et al., Hepatology 2008 (Hepatoblastoma...) : In vivo, compared with wild-type controls, FXR ( -/- ) mice displayed elevated messenger RNA ( mRNA ) levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interferon-inducible protein 10, and interferon-gamma in response to lipopolysaccharide (LPS)
Song et al., Vaccine 2009 (Foot-and-Mouth Disease) : Results indicated that when co-administered with a mixture of oil and GSLS, FMDV antigen induced significantly higher IgG titer and IgG1, IgG2a, IgG2b and IgG3 responses, production of IFN-gamma ( Th1 cytokine ) and IL-5 ( Th2 cytokine ) by splenocytes, as well as T and B lymphocyte proliferation in response to Con A and LPS than when FMDV antigen was used alone or mixed with either GSLS or oil
Zurhove et al., Science signaling 2008 (Inflammation) : LPS increases the proteolytic processing of the ectodomain of LRP1, which results in the gamma-secretase dependent release of the LRP1 intracellular domain ( ICD ) from the plasma membrane and its translocation to the nucleus, where it binds to and represses the interferon-gamma promoter
Wu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009 : As a positive control, LPS caused increases of TLR4 expression and both IFN-gamma and TNF-alpha production in the microglial cells
Chung et al., Mol Cells 2009 : Microarray results showed that the induction of monocyte chemoattractant protein-1alpha ( MCP-1alpha ) and macrophage inflammatory protein-1alpha ( MIP-1alpha ), MIP-1beta, MIP-1gamma, regulated upon activation, normal T-cell expressed and secreted ( RANTES ), macrophage inflammatory protein-2 ( MIP-2 ), and interferon-gamma inducible protein 10 ( IP 10 ) by A. actinomycetemcomitans LPS was increased to 12.5, 1.53, 9.09, 17.3, 2.82, 16.1, and 18.1 folds at 18 h, respectively
Ji et al., Hum Immunol 2009 : IFN-gamma decreased NRP-1 expression and LPS suppressed NRP-2 and plexin A1 expression
Popa et al., Eur Cytokine Netw 2009 (Arthritis, Rheumatoid...) : Stimulation with Salmonella LPS resulted in a significantly lower production of IL-1beta, TNF and a trend towards lower IL-6 and IFN-gamma production in RA patients compared to healthy volunteers
Ishikawa et al., Genetic vaccines and therapy 2009 : The ability of splenic cells to produce IFN-gamma and IL-4 upon in vitro stimulation with LPS or S. aureus and the serum titer of specific IgG1 and IgG2a anti-hsp65 antibodies after intramuscular immunization with pVAXhsp65 was then tested
Mukherjee et al., J Biol Chem 2009 : Gram negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type ( type 1 ) cytokines such as IFNgamma , TNFalpha, and IL8
Li et al., Am J Pathol 2009 : Finally, in the presence of either the phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma , LPS activates both caspase- and Cat B-dependent death pathways
Shultz et al., J Interferon Cytokine Res 2009 : Roles of IKK-beta, IRF1 , and p65 in the activation of chemokine genes by interferon-gamma
Cox et al., World J Gastroenterol 2009 : In addition, SCFAs inhibit LPS induced production of tumor necrosis factor-alpha and interferon-gamma in human PBMC
Shimura et al., Am J Pathol 2010 : Lipopolysaccharide (LPS) reduced H-PGDS expression, but interferon-gamma followed by LPS induced significant PGD2 production in a delayed time course at 6 hours
Son et al., Rheumatol Int 2010 (Syndrome) : However, upon stimulation with MDP, LPS , and PGN, the cells from the BS patient produced much lower levels of TNF-alpha, IL-10, G-CSF, and IFN-gamma than the normal donor cells
Chun et al., J Clin Immunol 2010 (Asthma...) : Interestingly, in the treatment-naïve group, short-term prednisolone significantly increased LPS induced TNF-alpha and IFN-gamma productions by PBMCs
Jin et al., Journal of translational medicine 2010 (Neoplasms) : We analyzed the kinetics of DC maturation by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induction in order to characterize the usefulness of mature DCs ( mDCs ) for immune therapy and to identify biomarkers for assessing the quality of mDCs
Yang et al., Arthritis Rheum 2010 (Arthritis) : Estrogen deficiency in ArKO mice was associated with significant increases in LPS induced serum interleukin-6 (IL-6), tumor necrosis factor, monocyte chemotactic protein 1, and interferon-gamma levels, which were significantly abrogated by administration of 16alpha-LE2, but not 8beta-VE2
Negishi et al., Am J Reprod Immunol 2011 : Lipopolysaccharide (LPS) induced Interferon (IFN)-gamma production by decidual mononuclear cells ( DMNC ) is interleukin (IL)-2 and IL-12 dependent
Schindler et al., J Immunol 1990 : Thus, IFN-gamma reduces IL-1 induced IL-1 synthesis by suppressing IL-1 induced transcription, whereas the same concentrations of IFN-gamma augment LPS induced IL-1 production by increasing transcription
Huang et al., J Food Sci 2010 (Hypersensitivity...) : Our data demonstrated that kaempferol significantly inhibited the lipopolysaccharide (LPS) induced production of monocyte derived chemokine (MDC), interferon gamma induced protein 10 (IP-10), and interleukin-8 (IL-8) in THP-1 cells
Roy et al., J Biol Chem 2011 (Keratitis...) : Interferon-gamma induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter
Xie et al., Int J Oncol 1993 : L929 parental cells and L929 cells selected for resistance to tumor necrosis factor ( TNF-alpha ) were incubated in vitro with various concentrations of TNF-alpha, interleukin-1, and lipopolysaccharide (LPS) in the presence or absence of mouse interferon-gamma (IFN-gamma)
Sokolova et al., Zh Mikrobiol Epidemiol Immunobiol 2011 : LPS37 and LPS37-MT induce TNFalpha and IFNgamma synthesis by human monocytes
Blanchard et al., Infect Immun 1985 : This suggests that LPS present in F-1 is responsible for IFN-gamma production and that an activated cell population is required
Heremans et al., J Immunol 1987 (Hypersensitivity, Delayed...) : These data indicate that LPS induces local production of IFN-gamma , which acts as a trigger or positive regulator of the reaction
Galy et al., Cell Immunol 1989 : The following recombinant cytokines, IL2, IL3, IL4, interferon-gamma (IFN-gamma), IFN-alpha, tumor necrosis factor-alpha (TNF alpha), and TNF beta, as well as thymosin fraction 5 and Escherichia coli lipopolysaccharide (LPS) , were not found to modify TEC proliferation but IFN-gamma and TNF alpha enhanced the effects of IL1
Blanchard et al., J Immunol 1986 : Cultures that were enriched for T cells and LGL by passage through nylon wool produced significant amounts of IFN-gamma in response to LPS only if first treated with IL 2 ... Because IFN-gamma is a potent activator of the bactericidal and cytocidal potential of macrophages, the induction of IFN-gamma by bacterial LPS may play an important role in resistance/recovery mechanisms against bacterial infections
Wada et al., J Interferon Res 1985 : In this study, we compared the IFN-gamma response to LPS with that to Con A in an attempt to clarify the cellular mechanisms responsible for in vivo LPS induced IFN-gamma production ... ( ii ) Spleen cells taken from infected mice produced little IFN-gamma in response to LPS , but they showed a higher IFN-gamma response to Con A than those from control mice ... ( iii ) By treating infected mice with immunosuppressive drugs or antibodies to T and natural killer cells before challenge with the inducers, it was indicated that different cellular systems are involved in the IFN-gamma responses to LPS and to Con A
Le et al., J Immunol 1986 : Bacterial lipopolysaccharide (LPS) induced human peripheral blood mononuclear cells ( PBMC ) to produce interferon-gamma (IFN-gamma) ... Monocytes play a mandatory accessory role in this process, because purified T lymphocytes failed to produce IFN-gamma in response to LPS and the addition of 2 % monocytes to T cell cultures resulted in an optimal LPS induced IFN-gamma production ... These results suggest that induction of IFN-gamma by LPS is due mainly to the generation of IL 1 and an enhanced expression of IL 2 receptors
Okamura et al., Infect Immun 1987 : Indomethacin augmented the induction of IFN-gamma by LPS or IL-2, and prostaglandin E2 reversed its effect
Akagawa et al., Jpn J Cancer Res 1987 (Neoplasms, Experimental) : These results suggest that IFN-gamma can restore LPS responsiveness of PEM from C3H/HeJ mice and that elevation of the intracellular calcium level is involved in the action of IFN-gamma
Matsumura et al., J Immunol 1988 : These results indicate that there is a mechanism of IFN-gamma induction by LPS which requires the direct contact between adherent cells and nonadherent cells without the participation of any soluble factor ( s ) from the adherent cells ... Therefore, it is concluded that both T cells ( presumably L3T4+T cells ) and asialo-GM1+ natural killer cells in the BCG primed C3H/HeJ cell cultures produced IFN-gamma in the presence of LPS , and the production was supported by the function of macrophages
Katz et al., J Exp Med 1988 : Four different human fibroblast cell lines synthesized C2 and factor B. Factor B synthesis was increased 12.1-fold by 50 ng/ml LPS and 7.1-fold by 100 U/ml IFN-gamma ... LPS induced a 4.7-fold greater increase in factor B protein than in factor B mRNA, whereas IFN-gamma stimulated comparable increases in protein and mRNA
Ando et al., Jpn J Cancer Res 1988 : Whereas hemmagglutinating virus of Japan ( HVJ ) enhanced the production of IFN-alpha, bacterial lipopolysaccharide (LPS) markedly enhanced the production of IFN-gamma ... Furthermore, the enhancement of production of IFN-gamma by LPS was completely abolished by polymixin B. IFN-gamma derived from LPS stimulated HBL-38 cells was purified to homogeneity and characterized
Nakane et al., Microbiol Immunol 1985 (Listeriosis) : IFN-gamma production in response to LPS was observed from the 5th through the 11th day after infection with Listeria, but it was not demonstrated in either mice infected with lower doses of viable Listeria or mice immunized with heat killed bacteria ... IFN-gamma induction by LPS was markedly suppressed in mice in which IFN-alpha/beta produced by Listeria infection itself had been depleted by treatment with anti-mouse IFN-alpha/beta antibody, but it was not inhibited in mice when IFN-alpha/beta induced not by Listeria infection but by LPS had been depleted by treatment with anti-mouse IFN-alpha/beta antibody
Steeg et al., J Immunol 1982 : The data suggest that LPS inhibits IFN-gamma regulation of macrophage Ia antigen expression by stimulating macrophage prostaglandin E2 production, and consequently enhancing intracellular cAMP levels
Funk et al., Endocrinology 1994 : Paradoxically, IFN gamma ( 50 micrograms ), a cytokine that usually synergizes with TNF, inhibited LPS induction of splenic PTHrP messenger RNA ( mRNA ) levels in LPS-sensitive C3H/OuJ ( OuJ ) and LPS-resistant C3H/HeJ ( HeJ ) mice
Smith et al., Transplantation 1995 (Disease Models, Animal...) : The IFN gamma produced in response to LPS stimulation was found to be derived from CD4+ and CD8+ T cells with little or no contribution from the NK1.1+ subpopulation of the GVH spleen
Wysocka et al., Eur J Immunol 1995 (Shock, Septic) : The priming effect of BCG on IFN-gamma production appears to be mostly due to its ability to increase TNF-alpha production, which acts as cofactor with LPS induced IL-12 in inducing IFN-gamma production, as shown by the ability of injection of TNF-alpha and LPS ( 1 microgram/mouse ), but not LPS alone, to induce IFN-gamma production ... Neutralizing anti-IL-12 antibodies, in addition to inhibiting the in vivo LPS induced IFN-gamma production, also completely protect BCG primed mice injected with up to 10 micrograms of LPS from shock induced death
Petrov et al., Vaccine 1994 : Liposomal LPS also induced more active accumulation of IFN-gamma in human peripheral blood mononuclear cells and less active accumulation of monokines, contributing to the realization of the toxic properties of endotoxin ( IL-1 alpha, TNF-alpha, IL-6 and GM-CSF )
Darmani et al., Int J Exp Pathol 1994 : Interferon-gamma also induced a 35 % increase in binding of FITC-LPS in U937 cells ( P < 0.0001 vs control cells )
Ogawa et al., Microbiology 1994 : P. gingivalis lipid A and its LPS induced stronger or comparable production of the cytokines interleukin-1 receptor antagonist ( IL-1ra ), IL-6, IL-8, granulocyte-macrophage colony stimulating factor and interferon-gamma as compared with compounds 506 and 516 in the culture supernatants of human peripheral blood monocytes or mononuclear cells
Car et al., J Exp Med 1994 (Body Weight...) : We report that IFN gamma R-/- mice have an increased resistance to LPS induced toxicity, this resistance manifesting well before the synthesis and release of LPS induced IFN-gamma
Heremans et al., Eur J Immunol 1994 (Shwartzman Phenomenon) : Since activated T cells and natural killer ( NK ) cells are the main if not the only potential source of LPS induced IFN-gamma , we investigated the relative importance of these cells in the development of the generalized Shwartzman-like reaction in mice by depleting them selectively with relevant monoclonal antibodies
Marchant et al., Eur J Immunol 1994 (Toxemia) : As IFN-gamma is another important mediator of LPS toxicity, we studied the effects of IL-10 on LPS induced IFN-gamma synthesis in vitro and in vivo ... First, we found that the addition of recombinant human IL-10 ( rhIL-10 ) ( 10 U/ml ) to human whole blood markedly suppressed LPS induced IFN-gamma release while neutralization of endogenously synthesized IL-10 resulted in increased IFN-gamma levels ... The ability of rIL-10 to inhibit LPS induced IFN-gamma synthesis was also observed in vivo in mice
Tannenbaum et al., J Immunol 1993 : The effects of IFN-gamma on LPS mediated TNFR expression were dependent on the sequence of exposure ; pretreatment with IFN-gamma was most effective at blocking response to LPS, whereas IFN-gamma added 1 h after initiation of LPS treatment had little or no effect
Galdiero et al., Infect Immun 1993 (Salmonella Infections) : LPS-S ( 1 microgram/ml ) induces IFN-gamma release from lymphocytes in notably smaller quantities than that obtained with LPS-R and slightly larger quantities than that obtained with porins
Cockfield et al., J Immunol 1993 : We found that concomitant administration of a neutralizing mAb to IFN-gamma inhibited not only the MHC expression induced by LPS but also the increased IFN-gamma mRNA expression, suggesting an autoregulatory role for IFN-gamma
Sioud et al., Eur J Immunol 1996 : The anti-TNF-alpha ribozyme treatment in vivo resulted in a more significant reduction of LPS induced IFN-gamma protein secretion compared to IL-10
D'Souza et al., Alcohol Clin Exp Res 1996 (Alcoholic Intoxication...) : Both acute and chronic alcohol treatment inhibited AM NO secretion in response to IFN-gamma , LPS, and IFN-gamma + LPS significantly
Smith et al., Arch Biochem Biophys 1996 : All three are induced in the RAW 264.7 macrophage cell line by LPS , by interferons-alpha/beta, and by interferon-gamma
Tennenberg et al., J Surg Res 1996 (Inflammation) : A subset of donor cocultures showed no IFN-gamma response to LPS
Barton et al., J Gen Virol 1996 : Conditioned media from Tat expressing cells reduced the level of nitrite accumulation in parental cells following IFN-gamma stimulation but not stimulation with LPS
Trepicchio et al., J Immunol 1996 (Inflammation) : In a mouse model of endotoxemia, pretreatment with rhIL-11 blocked LPS induced elevation of TNF-alpha, IL-1beta, and IFN-gamma serum levels, but had no effect on IL-12 p40, IL-6, or IL-10 serum levels
Hammoda et al., Journal of the Egyptian Society of Parasitology 1996 : Infective, stationary growth phase metacyclic promastigotes of Leishmania major were introduced to murine peritoneal macrophages and incubated with recombinant murine tumour necrosis factor (TNF) or with interferon gamma (IFN-gamma) in the presence of LPS
Jin et al., Cell 1997 : IFN gamma suppressed expression of SLPI and restored LPS responsiveness to SLPI producing cells ... Thus, SLPI is an LPS induced IFN gamma-suppressible phagocyte product that serves to inhibit LPS responses
Ghayur et al., Nature 1997 : Caspase-1 processes IFN-gamma inducing factor and regulates LPS induced IFN-gamma production
Pohl et al., Allergy 1997 (Hypersensitivity, Immediate) : LPS and SEE as single stimuli induced IFN-gamma production to the same extent in CBMC of neonates with high and low risk of atopy
Shibata et al., J Immunol 1997 : The treatments with soluble mannan or with cytochalasin D, in sharp contrast, did not inhibit LPS induced IL-12/IFN-gamma production or exogenous IL-12 induced IFN-gamma production
Trembleau et al., Eur J Immunol 1997 (Diabetes Mellitus, Type 1) : ( p40 ) 2 administration to NOD mice inhibits interferon-gamma but not IL-10 production in response to lipopolysaccharide (LPS) or to the putative autoantigen IA-2
Weinstock et al., Clin Infect Dis 1997 (Leishmaniasis, Diffuse Cutaneous...) : In whole blood cultures, induction of IFN-gamma by lipopolysaccharide (LPS) was completely negative, even after therapy
Bauché et al., Biol Reprod 1998 : Nitrite production in Sertoli cells and peritubular cells required both IFNgamma and TNF alpha and was potentiated by LPS , whereas IL-1alpha was ineffective
Smits et al., Clin Exp Immunol 1998 : Following exercise, significant decreases in LPS induced release of IL-6, tumour necrosis factor-alpha (TNF-alpha) and IL-10 and anti-CD2/anti-CD28 MoAb stimulated secretion of interferon-gamma (IFN-gamma) were observed
Fantuzzi et al., Blood 1998 : LPS induced IFNgamma was also reduced by an ICE inhibitor
Takeda et al., Immunity 1998 : In Propionibacterium acnes ( P. acnes ) -primed IL-18-deficient mice, LPS induced IFNgamma production was markedly reduced, despite normal IL-12 induction
Yeaman et al., J Immunol 1998 : We further found that polymorphonuclear neutrophils isolated from normal donors produce IFN-gamma in response to stimulation with LPS , IL-12, and TNF-alpha
Petrovsky et al., Cytokine 1998 : To investigate the latter, the authors performed measurements of lipopolysaccharide (LPS) stimulated whole blood, interferon gamma (IFN-gamma), tumour necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1) and IL-12 production in 13 healthy volunteers over 24 h
Sun et al., J Mol Cell Cardiol 1998 : Thus IFN-gamma , in the presence of LPS , reduced papillary muscle contraction and decreased responsiveness to beta-adrenoceptor stimulation through induction of NOS2 in the muscle
Xiao et al., Neuroreport 1998 : No IFN-gamma production by astrocytes could be induced by LPS , IL-10 or TGF-beta 1
Caivano et al., FEBS Lett 1998 : Bacterial lipopolysaccharide (LPS) in the presence of interferon gamma (IFNgamma) stimulates the synthesis of the cationic amino acid transporter 2B ( CAT-2B ) and inducible nitric oxide synthetase (iNOS) in RAW264 macrophages, which are thought to underlie the increased rate of arginine uptake into these cells and its conversion to nitric oxide, respectively
Wallis et al., Clin Diagn Lab Immunol 1998 (Acquired Immunodeficiency Syndrome) : Measurement of LPS induced TNF-alpha and mitogen- or antigen induced IFN-gamma can be performed simply and reproducibly in human immunodeficiency virus infected persons by the whole-blood culture method ... These values indicate that sample sizes of 8, 24, and 29 subjects would be sufficient to detect twofold changes in LPS induced TNF-alpha and in PHA- and antigen induced IFN-gamma respectively, if two baseline and two treatment determinations were obtained, and if the interpatient variability of changes in true levels from baseline to follow-up is negligible compared to the variability in the three weekly measurements
Németh et al., Brain Res Bull 1998 (Endotoxemia) : Intraperitoneal ( i.p. ) pretreatment with dantrolene ( 20 mg/kg ), but not verapamil ( 10 mg/kg, i.p. ) or diltiazem ( 20 mg/kg, i.p. ) suppressed the LPS induced ( 80 mg/kg, i.p. ) plasma levels of IL-12 and IFN-gamma in BALB/c mice
Németh et al., Shock 1998 (Endotoxemia) : Moreover, pretreatment of mice with PDTC ( 10-100 mg/kg, i.p. ) did not alter LPS induced ( 4 mg/kg ) production of IL-1alpha, IL-6, and IFN-gamma
Liu et al., J Immunol 1998 : Like IFN-beta, IFN-gamma suppresses the expression of both LPS and IL-1 induced IL-1beta
Schlaak et al., J Med Virol 1998 (Hepatitis C) : Lower baseline IL-12- and LPS induced IFN gamma , TNF alpha, and IL-12 production was observed in group 2 due to a possible dysfunction of accessory cells
Cheng et al., J Interferon Cytokine Res 1998 : A requirement for Stat1 binding to ISRE for IFN-gamma and IFN regulatory factor-1 (IRF-1) binding to ISRE for LPS , poly ( I:C ), and virus has been reported
Noguchi et al., Eur J Immunol 1998 : Granulocyte-macrophage colony stimulating factor-deficient ( GM-CSF-/- ) mice produce far lower serum levels of IFN-gamma in response to LPS than GM-CSF+/+ mice
Cembrzyńska-Nowak et al., Arch Immunol Ther Exp (Warsz) 1998 (Carcinoma, Small Cell...) : In contrast, the cells obtained from SCLC group produced little detectable levels of TNF-alpha ( median 12.0, range 3-45 U/ml ), IFN-gamma ( median 3, range 3-12 U/ml ) and IL-6 ( median 15, range 6-45 U/ml ) in response to LPS and interferons, mainly IFN-alpha ; ( median 3, range 3-12 U/ml ) in response to NDV
Faggioni et al., Am J Physiol 1999 (Obesity) : No differences were detected in LPS induced serum levels of interleukin (IL)-1beta, tumor necrosis factor, macrophage inflammatory protein-1alpha, and interferon-gamma in ob/ob mice compared with their own littermates
Isler et al., Am J Respir Cell Mol Biol 1999 : Both p35 and p40 mRNA levels were induced by lipopolysaccharide (LPS) and were further increased by interferon-gamma (IFN-gamma)
Faure et al., J Biol Chem 1999 : The decrease of LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds