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EGF — RHO
Text-mined interactions from Literome
Gildea et al., Cancer Res 2002
(Neoplasm Metastasis...) :
In addition, activation of RalA and expression of
Rho were
increased by
EGF stimulation in both the nonmetastatic and metastatic variants of the same cell line
Liberto et al., Oncogene 2002
:
Here, we demonstrate that
Rho is required for G1 to S progression in MCF10A mammary epithelial cells, both in
response to
EGF and in response to oncogenic Ras
Denys et al., Cancer Lett 2008
(Colonic Neoplasms...) :
In contrast,
EGF down-regulated
Rho-GTP levels in fibroblasts, giving permissive signals for Rac1 activation, fibroblast polarization, and invasion
Nakashima et al., Int J Oncol 2010
(Colonic Neoplasms...) :
In this study, we investigated the
role of
Rho-kinase in
epidermal growth factor (EGF) signaling in SW480 colon cancer cells ... We also found that
EGF induced
Rho-kinase activation
Vial et al., J Biol Chem 2012
:
EGF activates ERK/p90RSK and
Rho/Rho kinase signaling in A431 and DiFi colon cancer cells, leading to phosphorylation of filamin A (FLNa) and inactivation of the a5ß1 integrin receptor