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CARD14 — NFKB1
Text-mined interactions from Literome
Koseki et al., J Biol Chem 1999
:
Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the
CARD is
essential for
NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000
:
When expressed in cells,
CARD9 binds to BCL10 and
activates NF-kappaB
Bertin et al., J Biol Chem 2001
:
When expressed in cells,
CARD11 and CARD14
activate NF-kappaB and induce the phosphorylation of BCL10
Fontalba et al., J Immunol 2007
(Arthritis, Rheumatoid) :
Thus,
CARD8 may
control NF-kappaB activation through a regulatory loop
Jordan et al., Am J Hum Genet 2012
(Arthritis, Psoriatic...) :
CARD14 activates
nuclear factor kappa B (NF-kB) , and compared with wild-type CARD14, the p.Gly117Ser and p.Glu138Ala substitutions were shown to lead to enhanced NF-kB activation and upregulation of a subset of psoriasis associated genes in keratinocytes