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GRAP2 — IL8

Text-mined interactions from Literome

Hashimoto et al., Am J Respir Crit Care Med 2000 : In the present study, we therefore examined the role of p38 mitogen activated protein ( MAP ) kinase in DEP induced interleukin 8 (IL-8) and RANTES production by human bronchial epithelial cells ( BECs ) in order to clarify the intracellular signal transduction pathway that regulates IL-8 and RANTES production
Kato et al., Biorheology 2001 (Arteriosclerosis) : High glucose concentrations increased IL-8 mRNA levels in a MAPK-p38 dependent manner, which was suppressed by shear stress
Ling et al., Crit Care Med 2002 : In contrast to its effects on the janus kinase/STAT pathways, interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Krüll et al., Infect Immun 2004 : Subsequent interleukin-8 (IL-8) expression was dependent on p38-MAPK and ERK1/2 activation as demonstrated by preincubation of endothelial cells with specific inhibitors for the p38-MAPK ( SB202190 ) or ERK ( U0126 ) pathway
Jijon et al., Eur J Immunol 2005 : SAA dependent IL-8 gene expression required activation of the MAPK ERK, p38 and JNK in HT-29 cells
Torok et al., Infect Immun 2005 : When p38 activity was inhibited in TLR2- or TLR5 expressing cells, H. pylori dependent IL-8 secretion returned to the level observed in infected parental HEK293 cells that did not express TLR2 or TLR5 ; inhibition of p38 had no effect on IL-8 secretion from infected parental HEK cells
Wada et al., Immunol Lett 2005 (Sarcoma, Synovial) : A novel p38 MAP kinase inhibitor, R-130823, inhibited the release of IL-6, IL-8 and MMP-13 in a concentration dependent manner, but not that of IL-1beta or MMP-2
Wong et al., Allergy 2006 : Using various selective inhibitors for signaling molecules, we found that the inductions of IL-8 , MCP-1, and I-309 were mediated by either SCF activated ERK or TNF-alpha activated p38 MAPK, while the induction of IP-10 by TNF-alpha was mediated by both activated p38 MAPK and NF-kappaB
Kim et al., Mol Immunol 2007 (Ovarian Neoplasms) : Coexpression of dominant negative p38 ( DN-p38 ) suggested that p38 is involved in the IL-8 promoter activity which is regulated by saxatilin or TNF-alpha
Nonn et al., Carcinogenesis 2007 : We utilized the cytokines tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta to increase p38 dependent nuclear factor kappa-B (NFkappaB) activation and expression of pro-inflammatory genes cyclooxygenase-2 (COX-2), IL-6 and IL-8 in normal prostatic epithelial cells
Park et al., Toxicol Lett 2008 : The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen activated protein kinase ( MAPK ) pathway and/or extracellular signal ( ERK ) pathway
Bhavsar et al., Eur Respir J 2010 (Asthma) : We determined the concentration dependent effects of another p38 MAPK inhibitor, GW-A, on dexamethasone induced inhibition of interleukin (IL)-8 release from PBMCs. Cytokines were assayed using an ELISA based method
Jandhyala et al., Infect Immun 2010 (Escherichia coli Infections) : In contrast, inhibition of p38 has no detectable effect on interleukin-8 gene transcription, even though flagellin mediated activation of host p38 is critical for maximal interleukin-8 protein expression
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Dauletbaev et al., J Biol Chem 2011 : Down-regulation of cytokine induced interleukin-8 requires inhibition of p38 mitogen activated protein kinase ( MAPK ) via MAPK phosphatase 1-dependent and -independent mechanisms
Blume et al., Eur Respir J 2013 (Asthma...) : Inhibition of the extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase pathways selectively blocked apical CXCL8/IL-8 release via a post-transcriptional mechanism
Qiao et al., Invest Ophthalmol Vis Sci 2012 (MAP Kinase Signaling System) : S1P mediated IL-8 secretion is regulated by PTX, extracellular regulated protein kinases 1/2 ( ERK1/2 ), and p38 mitogen activated protein kinase ( MAPK )
Shapiro et al., Proc Natl Acad Sci U S A 1998 : In the presence of a specific p38 MAPK inhibitor (p38 inh) , IL-1beta induced HIV production was suppressed by more than 90 % and IL-1beta induced IL-8 production was suppressed completely, both with IC50 of 0.01 microM