◀ Back to NFKB1
IL2 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Iacobelli et al., J Immunol 1999
:
The current study clearly demonstrates that
IL-2 does not
induce I kappa B alpha degradation or
NF-kappa B activation in primary human T cells that respond to IL-2 by entering the cell cycle and avoiding apoptosis
Takeda et al., Science 1999
(Limb Deformities, Congenital...) :
In contrast, there was no impairment of
NF-kappaB activation
induced by either
interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Vig et al., J Biol Chem 1999
:
Modulation of tumor necrosis factor and
interleukin-1 dependent
NF-kappaB activity by mPLK/IRAK
Mortellaro et al., J Immunol 1999
:
New immunosuppressive drug PNU156804 blocks
IL-2 dependent proliferation and
NF-kappa B and AP-1 activation
Li et al., J Exp Med 1999
:
Accordingly, IKKbeta-deficient cells are defective in activation of IKK and
NF-kappaB in
response to either tumor necrosis factor alpha or
interleukin 1
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ),
interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and
NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Greene et al., Biochim Biophys Acta 1999
:
Interleukin-1 receptor associated kinase, IRAK, has been shown to activate
NFkappaB in
response to
interleukin-1
Belt et al., Am J Obstet Gynecol 1999
:
In this study we investigated the possible
role of the nuclear transcription factor
NF-kappaB in
interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with
interleukin 1
leads to rapid activation of the transcription factor
NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Egan et al., J Biol Chem 1999
:
Inhibition of
interleukin-1 stimulated
NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Sun et al., Nature 2000
:
Activation of
NF-kappaB by tumour-necrosis factor alpha and
interleukin-1 was unaffected in the mutant mice
Iber et al., Arch Biochem Biophys 2000
:
Suppression of CYP2C11 gene transcription by
interleukin-1 mediated by
NF-kappaB binding at the transcription start site
Prasad et al., J Infect Dis 2000
(Communicable Diseases...) :
Decreased production of
IL-2 in zinc deficiency may be
due to decreased activation of
NF-kappaB and subsequent decreased gene expression of IL-2 and IL-2 receptors
Takeuchi et al., Antioxid Redox Signal 2000
:
Thioredoxin inhibits tumor necrosis factor- or
interleukin-1 induced
NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Van Huffel et al., J Biol Chem 2001
:
NF-kappaB activation
induced by TNF and
interleukin-1 is inhibited by overexpression of ABIN-2
Fichorova et al., J Infect Dis 2001
(HIV Infections...) :
Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through
interleukin-1 mediated
NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Qian et al., J Biol Chem 2001
:
IRAK mediated translocation of TRAF6 and TAB2 in the
interleukin-1 induced activation of
NFkappa B
Bradbury et al., Cancer Res 2001
:
Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and
interleukin-1 induced
NF-kappaB activation and act as radiosensitizing agents
Tomita et al., Phytother Res 2002
:
We found that tea pigments potently suppress
IL-2 secretion, IL-2 gene expression and the
activation of
NF-kappaB in murine spleens enriched for CD4 ( + ) T cells, as expected
Wright et al., Am J Physiol Heart Circ Physiol 2002
:
However,
interleukin-1beta and phorbol 12-myristate 13-acetate also
activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Palanki et al., Curr Med Chem 2002
(Autoimmune Diseases) :
In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the
nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is
required for the transcriptional regulation of
IL-2 , IL-3, IL-4, IL-5, IL-8, IL-13, TNF alpha, and GM-CSF
Friedman et al., J Virol 2002
:
We demonstrate here that the E3 region of Ad inhibits the activation of
NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and
interleukin-1
Liacini et al., Matrix Biol 2002
(Osteoarthritis, Hip) :
Inhibition of
interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and
nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Herndon et al., Clin Immunol 2002
(Arthritis, Rheumatoid...) :
Since
NF-kappaB contributes to the transcriptional regulation of the
IL-2 promoter, the effect of the forced replenishment of p65 on IL-2 transcription was tested
Matsumoto et al., J Immunol 2002
:
NIK mutant T cells showed impaired proliferation and
IL-2 production in response to anti-CD3 stimulation, and these effects were
caused by impaired
NF-kappa B activity in both mature and immature T cells ; the impaired NF-kappa B activity in mature T cells was also associated with the failure of maintenance of activated NF-kappa B
Raychaudhuri et al., Clin Immunol 2002
(Hypertension, Pulmonary) :
However, mRNA expression was decreased compared to controls for
NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor,
interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Prasad et al., J Lab Clin Med 2002
:
Using transfection of expression vectors of anti-sense NF-kappaB p105 ( precursor of NF-kappaB p50 ) in cells, we showed that a decrease in gene expression of
IL-2 and IL-2 Ralpha may be partly
due to decreased activation of
NF-kappaB in zinc-deficient cells
Cogswell et al., J Biol Chem 2003
:
Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or
interleukin-1 induces the degradation of I kappa B, the
inhibitor of
NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Zheng et al., J Exp Med 2003
:
In contrast, our results indicate a lack of
involvement of
NF-kappaB in both
IL-2 and Akt induced survival pathways
Zhou et al., Toxicological sciences : an official journal of the Society of Toxicology 2003
:
Alcohol consumption decreases
IL-2 induced
NF-kappaB activity in enriched NK cells from C57BL/6 mice ... In this study we show by electrophoretic mobility-shift assay ( EMSA ) that enriched splenic NK cells from EtOH consuming C57BL/6 mice exhibit reduced
NF-kappaB and AP-1 binding activity in
response to
IL-2 stimulation as compared to the water drinking mice
Brach et al., Cell Growth Differ 1992
(Lymphoma, Large B-Cell, Diffuse) :
Activation of
NF-kappa B by
interleukin 2 in human blood monocytes ... We report here that
interleukin 2 (IL-2) acts on human blood monocytes by
enhancing binding activity of the transcription factor
NF-kappa B to its consensus sequence in the 5 ' regulatory enhancer region of the IL-2 receptor alpha chain ( p55 ) ... Similarly,
IL-2 activates
NF-kappa B in the human monocytic cell line U 937, but not in resting human T-cells ... Enhanced NF-kappa B binding activity is followed by functional activation in that inducibility of the IL-2 receptor alpha chain is mediated by enhanced
NF-kappa B binding and that a heterologous promoter containing the NF-kappa B consensus sequence ( -291 to -245 ) of the
IL-2 receptor alpha chain gene is
activated ... In addition,
IL-2 is capable of increasing transcript levels of the p50 gene coding for the p50 subunit of the NF-kappa B transcription factor, whereas mRNA levels of the p65
NF-kappa B gene remained
unchanged
Jiang et al., J Biol Chem 2004
:
Without ERK activation,
interleukin-1beta induces only acute and transient
NF-kappaB activation
Takada et al., J Biol Chem 2004
:
PTD-p65-P1 suppressed
NF-kappaB activation
induced by lipopolysaccharide,
interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Arai et al., Biochem Pharmacol 2004
:
In the T cells stimulated with mitogenic lectin phytohemagglutinin ( PHA ) in conjunction with phorbol myristate acetate ( PMA ), 6-formylpterin suppressed the
NF-kappaB dependent transcription, the production of cytokines ( IFN-gamma and
IL-2 ) and the cell proliferation
Shishodia et al., J Biol Chem 2004
(Inflammation...) :
Guggulsterone suppressed DNA binding of
NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and
interleukin-1
Abboushi et al., J Immunol 2004
:
Ceramide
inhibits IL-2 production by preventing protein kinase C-dependent
NF-kappaB activation : possible role in protein kinase Ctheta regulation ... As expected, the repression of
NF-kappaB activation by ceramide
led to the reduction of transcription of the
IL-2 gene in a dose dependent manner
Kwon et al., Mol Cell Biol 2004
:
Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not
interleukin-1 dependent
NF-kappaB activation
Nishiyama et al., Int Immunopharmacol 2005
:
Antisense
NF-kappaB p65/RelA oligonucleotides inhibited p65/RelA mRNA expression,
diminished IL-2 mRNA expression in the costimulated HPTC and reduced HPTC proliferation to the same extent as CsA added simultaneously with the costimulation
Feng et al., Mol Cell Biol 2005
:
The LIM protein Ajuba influences
interleukin-1 induced
NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Wu et al., Transplant Proc 2005
:
On posttransplant day 7, the serum albumin level significantly improved, the serum total bile acid and alanine aminotransferase levels were significantly lower, the serum
interleukin-2 and interferon-gamma levels were significantly lower, and the activation of transcription factor
NF-kappaB in peripheral blood T lymphocytes was significantly
suppressed in the combination group in comparison with those in the CsA group ( all P < .05 ) or control group ( all P < .01 ), and a histological examination revealed apparent difference in the severity of rejection between the combination group and CsA group ( P < .05 ) or control group ( P < .01 )
Arima et al., J Immunol 1992
:
Using electrophoretic mobility shift assays and DNA-protein cross linking techniques, we demonstrate that
IL-2 binding to functional forms of the human IL-2R
activates nuclear expression of the eukaryotic transcription factor
NF-kappa B ...
IL-2 activation of nuclear
NF-kappa B expression is regulated in part at a post-translational level, involving the rapid translocation of both the 50- and 65-kDa subunits of NF-kappa B from the cytoplasm to the nucleus ...
IL-2 induction of
NF-kappa B through the IL-2R beta subunit was both correlated with activation of the endogenous IL-2R alpha gene and critically dependent upon the presence of a serine-rich cytoplasmic domain within IL-2R beta ( amino acid residues 267-312 )
Wu et al., World J Gastroenterol 2005
:
On the 7th post-transplant day the serum albumin level significantly improved in the RES C group, the serum total bile acid and alanine aminotransferase ( ALT ) levels were significantly lower in the RES C group, the serum
IL-2 and INF-gamma levels were significantly lower in the RES C group, and the activation of transcription factor
NF-kappaB in peripheral blood T lymphocytes was significantly
suppressed in the RES A, B, and C groups in comparison to those in the control group
Yun et al., Toxicology 2006
:
These results suggest that PhIP has potential immunosuppressive effects by inhibiting T-cell proliferation and
IL-2 expression through down regulation of ROS generation and thereby
inhibiting NF-kappaB , AP-1 and NF-AT activation
Zhang et al., Alcohol Clin Exp Res 2005
(HIV Infections) :
Alcohol inhibited
IL-2 induced
NF-kappaB p65 protein expression and calcium mobilization by NK cells ... Alcohol, through the inhibition of
IL-2 induced
NF-kappaB p65 protein expression and intracellular calcium mobilization, suppressed NK cell production of CC chemokines
Narumi et al., J Immunol 1992
:
IFN-gamma and
IL-2 cooperatively
activate NF kappa B in murine peritoneal macrophages ... Although the
effects of LPS and
IFN-gamma/IL-2 on
NF kappa B activity were both transient, response to LPS was detected earlier and declined more rapidly than that seen with IFN-gamma/IL-2 treatment ... The
activation of
NF kappa B by
IFN-gamma/IL-2 did not depend upon protein synthesis
Wang et al., Nat Immunol 2006
:
Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR )
-interleukin 1 receptor (IL-1R) signaling and subsequent
activation of
NF-kappaB and AP-1, transcriptional activators of innate immunity
Sánchez-Valdepeñas et al., J Immunol 2006
:
Previous evidence suggested that
NF-kappaB inducing kinase (NIK) might
regulate IL-2 synthesis
Sanchez-Lockhart et al., J Immunol 2006
:
CD28 signaling through PI3K results in the recruitment of protein kinase C (PKC)theta to the cSMAC,
activation of
NF-kappaB , and induction of
IL-2 transcription ... We show that induction of
IL-2 secretion under these conditions did not require expression of PKCtheta and did not
induce NF-kappaB activation or IL-2 transcription
Kim et al., J Immunol 2006
:
Adiponectin was found to suppress the IL-2 enhanced cytotoxic activity of NK cells without affecting basal NK cell cytotoxicity and to inhibit
IL-2 induced
NF-kappaB activation via activation of the AMP activated protein kinase, indicating that it suppresses IL-2 enhanced NK cell cytotoxicity through the AMP activated protein kinase mediated inhibition of NF-kappaB activation
Molinero et al., Hum Immunol 2006
:
IL-2 effect involved Jak3/STAT5, p38 MAPK, p70 ( 56 ) kinase, Lck/fyn kinases, and
NF-kappaB
LaVallie et al., J Biol Chem 2006
(Osteoarthritis) :
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for
activation of
NF-kappaB by tumor necrosis factor and
interleukin-1 in articular chondrocytes
Hayashi et al., J Immunol 2006
:
Depletion of FLNa by RNA interference did not affect TCR induced early tyrosine phosphorylation or actin polymerization but, nevertheless, resulted in impaired
IL-2 expression by human primary T cells and reduced
activation of
NF-kappaB , AP-1, and NFAT reporter genes in transfected T cells
Komine et al., Mol Immunol 2007
(Periodontitis) :
Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of
interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the
activation of
NF-kappaB in human oral epithelial HSC-2 cells
Suzuki et al., Trends Immunol 2006
:
Although each system seems to possess distinct activation mechanisms,
interleukin-1 receptor associated kinase ( IRAK)-4 is
essential for
NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Wullaert et al., J Biol Chem 2007
:
Similar to the other ABINs, ABIN-3 binds to A20 and inhibits
NF-kappaB activation
induced by tumor necrosis factor,
interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Ahn et al., J Biol Chem 2007
:
Besides TNF, gamma-tocotrienol also abolished
NF-kappaB activation
induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke,
interleukin-1beta , and epidermal growth factor
Hohmann et al., J Biol Chem 1992
(Leukemia, Promyelocytic, Acute) :
NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and
interleukin-1 was inhibited by staurosporin
Manna et al., Clin Cancer Res 2007
(Inflammation...) :
We showed by DNA binding assay that
NF-kappaB activation
induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide,
interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Krasnow et al., Cytokine 1991
(Lymphoma, T-Cell) :
Tumor necrosis factor-alpha,
interleukin 1, and phorbol myristate acetate are independent
activators of
NF-kappa B which differentially activate T cells
Touma et al., J Immunol 2007
:
The effect of I kappa BNS on the
IL-2 promoter, unlike c-Rel, is
dependent on the
NF-kappaB rather than the CD28RE site ; mutation of the NF-kappaB site extinguishes the induction of transcription by I kappa BNS in transfectants and prevents association of I kappa BNS with IL-2 promoter DNA
Shembade et al., J Virol 2007
:
Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and
interleukin-1 mediated
NF-kappaB activation
Dey et al., Cell Death Differ 2008
:
We show in this study that R-Roscovitine can downregulate
nuclear factor-kappa B (NF-kappaB) activation in
response to tumor necrosis factor (TNF)alpha and
interleukin 1
Kim et al., Mol Pharmacol 2008
(Inflammation...) :
BOT-64 attenuates
NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha,
interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Shifera et al., Mol Immunol 2008
(Immunologic Deficiency Syndromes) :
The suppression of
IL-2 induction was solely
due to the inhibition of
NF-kappaB activation as the mutations did not impair the activation of AP-1 and NFAT
Xiao et al., J Biol Chem 2008
:
Pellino 3b negatively regulates
interleukin-1 induced TAK1 dependent
NF kappaB activation
Prasad et al., Mol Med 2008
(Lymphoma, T-Cell, Cutaneous) :
In HUT-78 ( T helper 0 [ Th ( 0 ) ] cell line ), we showed that a decrease in gene expression of
interleukin-2 (IL-2) and IL-2 receptor alpha ( IL-2Ralpha ) were
due to decreased activation of
nuclear factor-kappaB (NF-kappaB) in zinc deficient cells
Dasu et al., Diabetes 2008
:
High glucose increased TLR expression, myeloid differentiation factor 88,
interleukin-1 receptor associated kinase-1, and
nuclear factor-kappaB (NF-kappaB) p65 dependent
activation in THP-1 cells
Wijagkanalan et al., Mol Pharmacol 2008
(Pneumonia) :
DPML significantly inhibited tumor necrosis factor alpha,
interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and
inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could
activate both mitogen activated protein kinases and
NF-kappaB
Sanchez-Lockhart et al., J Immunol 2008
:
CD28 mediated signaling through PI3K results in the recruitment of protein kinase C-theta (PKCtheta) to the cSMAC,
activation of
NF-kappaB , and up-regulation of
IL-2 transcription
Gao et al., Cell Mol Life Sci 2009
:
Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the
activation of
NF-kappaB by tumor necrosis factor ( TNFalpha ),
interleukin-1beta (IL-1beta) and TLR ligands
de Mejia et al., Peptides 2009
(Inflammation) :
The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ),
interleukin-1beta production ( IC ( 50 ) =13 microM ),
nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Sheller et al., Exp Lung Res 2009
(Asthma...) :
Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory
interleukin , IL-10, was
suppressed by
NF-kappa B activation
Chan et al., J Pathol 2010
(Lymphoma, Extranodal NK-T-Cell) :
Interleukin-2 induces
NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells
Munitz et al., Gastroenterology 2010
(Colitis...) :
In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6,
interleukin-1beta , and tumor necrosis factor alpha ) and
activation of MAPK and
NF-kappaB in Pirb-/- macrophages following bacterial activation
Schreck et al., EMBO J 1991
:
NAC and other thiol compounds also blocked the
activation of
NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester,
interleukin-1 , lipopolysaccharide and lectin
Hazan et al., Proc Natl Acad Sci U S A 1990
:
Interleukin 2 induced proliferation but not
NF-kappa B translocation or LTR transactivation
Mahon et al., J Biol Chem 1995
(Lymphoma, T-Cell...) :
The tyrosine kinase inhibitor herbimycin A was found to block
NF-kappa B stimulation in
response to
interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Lewis et al., Mol Cell Biol 1994
:
Mutational analysis of the -127/-118 NF-kappa B site indicates that both
NF-kappa B and HMG-I(Y) binding at this site are
essential for
interleukin-1 induction of the promoter
Scheinman et al., Mol Cell Biol 1995
:
In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or
interleukin 1
activation of
NF-kappa B at the levels of both DNA binding and transcriptional activation
Ivanov et al., J Immunol 1994
:
These experiments also demonstrated a key
role for
NF-kappa B and AP-1 in the transcriptional regulation of the
IL-2 gene by TCR- and Ly6A/E mediated signaling
Ng et al., J Biol Chem 1994
:
Although tumor necrosis factor (TNF) and
interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of
NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Costello et al., Cell Growth Differ 1993
:
Increase of
IL-2R alpha gene transcription
involves the enhanced binding of the transcription factor
NF-kappa B to its consensus sequence in the 5'-regulatory region of the IL-2R alpha gene
Pimentel-Muiños et al., J Immunol 1994
:
Interestingly, a neutralizing anti-TNF-alpha mAb strongly inhibited the proliferation,
IL-2R alpha expression, and
activation of the
nuclear factor (NF)-kappa B induced on human purified T lymphocytes by an immobilized anti-CD3 mAb ( imm.anti-CD3 )
McGuire et al., J Virol 1993
:
Several studies have shown that tax transactivation of the
IL-2R alpha-chain promoter is
mediated by binding sites for the transcriptional activator
NF-kappa B , and this mechanism has also been implicated in the tax activation of IL-2 promoter activity
Paliogianni et al., J Immunol 1993
:
IL-2 dependent
IL-2R alpha expression in PMA blasts and
NF-kB induction in resting human T cells were also inhibited by Dex
Brach et al., J Immunol 1993
:
Transcriptional activation of the macrophage colony stimulating factor gene by
IL-2 is associated with secretion of bioactive macrophage colony stimulating factor protein by monocytes and
involves activation of the transcription factor
NF-kappa B
Good et al., EMBO J 1996
:
In the present study, we demonstrate that neither
NF-kappa B/Rel nor CREB/ATF is
sufficient for Tax mediated activation of the
IL-2 promoter
Mori et al., Blood 1997
(Asthma...) :
NF-AT and
NF-kappaB were not significantly
induced by
IL-2 stimulation
De Valck et al., Biochem Biophys Res Commun 1997
:
However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit
NF-kappaB activation
induced by tumor necrosis factor,
interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Bowie et al., J Biol Chem 1997
:
Here we have investigated the effect of a range of putative antioxidants on
NF-kappaB activation by
interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Chaturvedi et al., J Biol Chem 1997
:
As sanguinarine also inhibited
NF-kappaB activation
induced by
interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers
Muñoz-Fernández et al., J Allergy Clin Immunol 1997
:
Moreover, supplementing the cultures with high doses of
IL-2 reverted anti-TNF-alpha inhibition of cell proliferation but did not
affect the inhibition of HIV p24 antigen release or
NF-kappa B activation in the same cultures
Gri et al., J Biol Chem 1998
(Cell Transformation, Viral) :
Synergistic
regulation of the human
interleukin-12 p40 promoter by
NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Kalli et al., Mol Cell Biol 1998
:
Together, these results suggest a mechanism by which signals from the T-cell antigen receptor and either CD28 or IL-1 synergistically
regulate IL-2 gene transcription by modulating
NF-kappaB nuclear translocation
Giri et al., J Biol Chem 1998
(Lymphoma, T-Cell...) :
HuT-78 cells were also resistant to
NF-kappaB activation
induced by phorbol ester, H2O2, ceramide, endotoxin, and
interleukin-1
Heitmeier et al., J Biol Chem 1998
:
Double stranded RNA induced inducible nitric-oxide synthase expression and
interleukin-1 release by murine macrophages
requires NF-kappaB activation
Arima et al., Leuk Res 1998
(Leukemia, Prolymphocytic...) :
The binding of
interleukin-2 (IL-2) to its receptor on normal T cells
induces nuclear expression of
nuclear factor kappaB (NF-kappaB) , activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation ... Electrophoretic mobility-shift assays revealed that recombinant
IL-2 increased
NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells
Sen et al., Biochem Biophys Res Commun 1998
:
At 100 microM, LA did not but LA-Plus inhibited H2O2 induced NF-kappaB activation and
NF-kappaB directed
IL-2 receptor expression
Schwager et al., Vet Immunol Immunopathol 1998
(Ascorbic Acid Deficiency...) :
The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor
NF-kappa B is sensitive to ROI and
regulates the expression of
interleukin genes
Harhaj et al., J Biol Chem 1998
:
The
interleukin-2 gene is
regulated by
NF-kappaB among other transcription factors, in part, via a CD28 responsive element (CD28RE) present in the IL-2 promoter
McDonald et al., Blood 1998
:
In peripheral blood lymphocytes ( PBL ), however, both
IL-2 and IL-15 were potent
inducers of
NF-kappaB activation
Béraud et al., Proc Natl Acad Sci U S A 1999
:
The compound had virtually no effect on tumor necrosis factor- and
interleukin-1 induced
NF-kappaB activities