◀ Back to NFKB1

IL4 — NFKB1

Text-mined interactions from Literome

Takeda et al., Science 1999 (Limb Deformities, Congenital...) : In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Alaaeddine et al., Arthritis Rheum 1999 (Osteoarthritis) : IL-4 had no effect on TNFalpha up-regulation of NF-kappaB , and a slight decrease was noted with IL-10 and IL-13 at the highest concentration used ( 5 ng/ml )
Vig et al., J Biol Chem 1999 : Modulation of tumor necrosis factor and interleukin-1 dependent NF-kappaB activity by mPLK/IRAK
Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase, IRAK, has been shown to activate NFkappaB in response to interleukin-1
Belt et al., Am J Obstet Gynecol 1999 : In this study we investigated the possible role of the nuclear transcription factor NF-kappaB in interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with interleukin 1 leads to rapid activation of the transcription factor NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Egan et al., J Biol Chem 1999 : Inhibition of interleukin-1 stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Sun et al., Nature 2000 : Activation of NF-kappaB by tumour-necrosis factor alpha and interleukin-1 was unaffected in the mutant mice
Iber et al., Arch Biochem Biophys 2000 : Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site
Paludan et al., Arch Virol 2000 : IL-4 reduced virus induced TNF-alpha secretion and nuclear factor (NF)-kappaB activation significantly, but less in cells concomitantly treated with IFN-gamma
Bendixen et al., Proc Natl Acad Sci U S A 2001 : We show here that IL-4 inhibits receptor activator of NF-kappaB ligand induced osteoclast differentiation through an action on osteoclast precursors that is independent of stromal cells
Takeuchi et al., Antioxid Redox Signal 2000 : Thioredoxin inhibits tumor necrosis factor- or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Cianferoni et al., Blood 2001 : The inhibitory effect of ASA on IL-4 transcription was not mediated by decreased nuclear expression of the known salicylate target nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of, but not overlapping, the NF of activated T cells- and NF-kappaB binding P1 element
Van Huffel et al., J Biol Chem 2001 : NF-kappaB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2
Abu-Amer et al., J Clin Invest 2001 : It is shown here that IL-4 reduces NF-kappaB nuclear translocation by inhibiting IkappaB phosphorylation, thus markedly inhibiting NF-kappaB DNA binding activity and blocking osteoclastogenesis entirely ... Residual translocation of NF-kappaB in the presence of IL-4 , however, suggests that nuclear mechanisms must primarily account for inhibition of NF-kappaB DNA binding and blockade of osteoclastogenesis
Fichorova et al., J Infect Dis 2001 (HIV Infections...) : Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through interleukin-1 mediated NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Bradbury et al., Cancer Res 2001 : Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and interleukin-1 induced NF-kappaB activation and act as radiosensitizing agents
Zamorano et al., Int Immunol 2001 : IL-4 enhanced TNF-alpha induced activation of the transcription factor NF-kappaB ... Supporting this hypothesis, IL-4 also increased NF-kappaB activation induced by anti-CD3 antibodies in primary T cells and protected them from apoptosis induced by receptor engagement
Wei et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Consistent with this observation, the inhibitory effects of IL-4 on RANKL induced NF-kappa B and mitogen activated protein kinase activation are STAT6 dependent
Beppu et al., Biochim Biophys Acta 2002 (Carcinoma, Squamous Cell...) : Regarding their mechanisms to inhibit the expression of MMP-9 and uPA, DEX and IL-4 had no effect on the cell surface levels of TNFalpha receptors, but inhibited the activation of NF-kappaB and NF-kappaB dependent gene expression
Wright et al., Am J Physiol Heart Circ Physiol 2002 : However, interleukin-1beta and phorbol 12-myristate 13-acetate also activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Palanki et al., Curr Med Chem 2002 (Autoimmune Diseases) : In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4 , IL-5, IL-8, IL-13, TNF alpha, and GM-CSF
Goletti et al., Cytokine 2002 : IL-4 inhibited LTR-driven transcription triggered by PMA stimulation of U1 cells, and this effect was dependent upon intact NF-kappaB but not Sp-1 binding sites
Friedman et al., J Virol 2002 : We demonstrate here that the E3 region of Ad inhibits the activation of NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and interleukin-1
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : Inhibition of interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Raychaudhuri et al., Clin Immunol 2002 (Hypertension, Pulmonary) : However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Cogswell et al., J Biol Chem 2003 : Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or interleukin-1 induces the degradation of I kappa B, the inhibitor of NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Kim et al., Mol Cells 2003 : IGF-1 increased the activity of signal transducer and activator of transcription 6 ( STAT6 ) in response to IL-4 , and activated NF-(kappa)B
Zamorano et al., J Immunol 2003 : We previously found that IL-4 and TNF-alpha cooperate in the activation of STAT6 and NF-kappaB , suggesting that these transcription factors are regulated by common intracellular signaling pathways
Jiang et al., J Biol Chem 2004 : Without ERK activation, interleukin-1beta induces only acute and transient NF-kappaB activation
Ackermann et al., Immunology 2004 : In studies using human intestinal epithelial cells ( HT29 ), multiple inhibitors of the transcription factor nuclear factor-kappaB (NF-kappaB) , including a dominant negative IkappaBalpha-serine mutant, inhibited both IL-4- and IFN dependent increases in pIgR expression ... Finally, reporter gene studies with NF-kappaB enhancer elements indicated that IFN-gamma alone and IL-4 in combination with other cytokines activated NF-kappaB in HT29 cells
Yamamoto et al., Biochem Biophys Res Commun 2004 (Inflammation) : Involvement of NF-kappaB in TGF-beta mediated suppression of IL-4 signaling
Takada et al., J Biol Chem 2004 : PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Dedeoglu et al., Int Immunol 2004 : IL-4 induced STAT6 binding to a site in the 5 ' upstream region of the AID gene, while CD40 ligation induced NFkappaB binding to two sites in that region
Li-Weber et al., Eur J Immunol 2004 : In this study, we show that the IL-4 promoter is synergistically activated by NF-kappa B , NF-AT and NF-IL6 at the NF-kappa B/NF-AT/NF-IL6 composite sites ... Inhibition of NF-kappa B nuclear translocation in living cells blocked binding of NF-kappa B to the IL-4 promoter ... The data provide first evidence that NF-kappa B is directly involved in IL-4 transcription
Lgssiar et al., Experimental biology and medicine (Maywood, N.J.) 2004 (Diabetes Mellitus, Experimental) : Interleukin-11 prevented diabetes without affecting insulitis ; attenuated TNF-alpha and IFN-gamma response ; and stimulated IL-4 production and inhibited activation of IKK-alpha, NF-kappaB , and AP-1
Xu et al., World J Gastroenterol 2004 : NF-kappaB decoy ODNs completely abrogated IL-4 induced DC maturation and allocostimulatory activity as well as LPS induced NF-kappaB activation and IL-12 protein expression in DCs
Shishodia et al., J Biol Chem 2004 (Inflammation...) : Guggulsterone suppressed DNA binding of NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and interleukin-1
Kwon et al., Mol Cell Biol 2004 : Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not interleukin-1 dependent NF-kappaB activation
Jain et al., J Clin Invest 2004 (Ectodermal Dysplasia...) : This suggests that these NF-kappaB components have different activation requirements and that IL-4 can augment some but not all NEMO dependent NF-kappaB signaling
Lee et al., Prostate 2005 (Prostatic Neoplasms) : IL-4 increases NF-(kappa)B transcriptional activity in prostate cancer cells which can be blocked by the addition of IL-4 antibody ... IL-4 can also rapidly activate NF-kappaB ... Furthermore, the IL-4 induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4 induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway
Feng et al., Mol Cell Biol 2005 : The LIM protein Ajuba influences interleukin-1 induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Park et al., Biochemistry 2005 : Inhibition of NF-kappaB by cobrotoxin resulted in reductions in the LPS induced expressions of COX-2, iNOS, cPLA(2), IL-4 , and TNF-alpha in astrocytes and in COX-2 expression induced by SNP, LPS, and TNF-alpha in astrocytes
Mangashetti et al., J Immunol 2005 (Bone Resorption...) : Thus, we reveal that IL-4 acts directly on mature osteoclasts and inhibits bone resorption by inhibiting NF-kappaB and Ca ( 2+ ) signaling
Wang et al., Nat Immunol 2006 : Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity
Paintlia et al., J Immunol 2006 (Demyelinating Diseases...) : IL-4 induced peroxisome proliferator activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system ( CNS ) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions : implication for CNS demyelinating diseases
LaVallie et al., J Biol Chem 2006 (Osteoarthritis) : Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
Jang et al., Cell Immunol 2006 : In fact, IL-4 induced specific activation of NF-kappaB , Akt, and Erk in Jurkat T cells and partially rescued these cells from dexamethasone induced apoptosis
Komine et al., Mol Immunol 2007 (Periodontitis) : Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the activation of NF-kappaB in human oral epithelial HSC-2 cells
Suzuki et al., Trends Immunol 2006 : Although each system seems to possess distinct activation mechanisms, interleukin-1 receptor associated kinase ( IRAK)-4 is essential for NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Frasca et al., Exp Gerontol 2007 : Therefore, NF-kappaB is not involved in the decreased response of old B cells to anti-CD40/IL-4
Wullaert et al., J Biol Chem 2007 : Similar to the other ABINs, ABIN-3 binds to A20 and inhibits NF-kappaB activation induced by tumor necrosis factor, interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Ahn et al., J Biol Chem 2007 : Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta , and epidermal growth factor
Hohmann et al., J Biol Chem 1992 (Leukemia, Promyelocytic, Acute) : NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and interleukin-1 was inhibited by staurosporin
Manna et al., Clin Cancer Res 2007 (Inflammation...) : We showed by DNA binding assay that NF-kappaB activation induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide, interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Thieu et al., J Leukoc Biol 2007 : IL-4 stimulated NF-kappaB activity is required for Stat6 DNA binding ... IL-4 induced NF-kappaB p52 production requires PI-3K activity and correlates with IkappaB kinase phosphorylation and TNF receptor associated factor 3 degradation
Krasnow et al., Cytokine 1991 (Lymphoma, T-Cell) : Tumor necrosis factor-alpha, interleukin 1, and phorbol myristate acetate are independent activators of NF-kappa B which differentially activate T cells
Liu et al., J Immunol 2007 : Activation of NF-kappaB , STAT6, and STAT1 was induced in eosinophils by TNF-alpha, IL-4 , and IFN-gamma, respectively
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Voboril et al., Neoplasma 2007 (Colorectal Neoplasms) : IL-4 or IL-10 ( 1, 10, 100 ng/ml ) neither inhibited growth and clonogenicity nor activated NF-kappaB , but they sensitized cells to irradiation in a dose dependent manner
Dey et al., Cell Death Differ 2008 : We show in this study that R-Roscovitine can downregulate nuclear factor-kappa B (NF-kappaB) activation in response to tumor necrosis factor (TNF)alpha and interleukin 1
Kim et al., Mol Pharmacol 2008 (Inflammation...) : BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Park et al., J Microbiol Biotechnol 2008 (Hypersensitivity, Immediate) : These extracts also inhibited mRNA expression of TNF-alpha and IL-4 , as well as NF-kappaB activation in RBL-2H3 cells induced by the IgE-antigen complex
Xiao et al., J Biol Chem 2008 : Pellino 3b negatively regulates interleukin-1 induced TAK1 dependent NF kappaB activation
Dasu et al., Diabetes 2008 : High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor associated kinase-1, and nuclear factor-kappaB (NF-kappaB) p65 dependent activation in THP-1 cells
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Gao et al., Cell Mol Life Sci 2009 : Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the activation of NF-kappaB by tumor necrosis factor ( TNFalpha ), interleukin-1beta (IL-1beta) and TLR ligands
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Lohoff et al., J Biol Chem 2010 : We also show that Egr-1, nuclear factor of activated T cell, and NF-kappaB cooperatively bind to an NFAT/NF-kappaB overlapping IL-4 enhancer element and activate the IL-4 promoter synergistically
Sheller et al., Exp Lung Res 2009 (Asthma...) : Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory interleukin , IL-10, was suppressed by NF-kappa B activation
Yao et al., Inflamm Res 2010 : Moreover, NF-kappaB p50, COX-2, and iNOS levels in SF were markedly suppressed by AD-IL-18BP/IL-4 ... AD-IL-18BP/IL-4 can suppress the production and expression of inflammatory cytokines such as COX-2, iNOS, and NF-kappaB in LPS stimulated SF
Trinh et al., Arch Pharm Res 2009 (Pruritus) : These curcuminoids also inhibited degranulation, protein expression of TNF-alpha and IL-4 , and transcription factor NF-kappaB activation in IAC induced RBL-2H3 cells
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Schreck et al., EMBO J 1991 : NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1 , lipopolysaccharide and lectin
Mahon et al., J Biol Chem 1995 (Lymphoma, T-Cell...) : The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Lewis et al., Mol Cell Biol 1994 : Mutational analysis of the -127/-118 NF-kappa B site indicates that both NF-kappa B and HMG-I(Y) binding at this site are essential for interleukin-1 induction of the promoter
Clarke et al., Eur J Immunol 1995 : Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells ... We investigated whether IL-4 could inhibit the up-regulation of kappa light chain and activation of NF kappa B by LPS in 70Z/3 ... IL-4 was also found partially to inhibit NF kappa B activity induced by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta)
Scheinman et al., Mol Cell Biol 1995 : In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or interleukin 1 activation of NF-kappa B at the levels of both DNA binding and transcriptional activation
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Dokter et al., Leukemia 1996 : Neither IL-10 nor IL-4 inhibited LPS induced NF-kappa B binding activity
Takeshita et al., J Immunol 1996 : Electrophoretic mobility shift assays showed that IL-4 , but not IL-10, inhibited nuclear NF-kappaB activity, and that IL-4 and IL-10 did not affect NF-IL-6 activity
Yanagihara et al., J Allergy Clin Immunol 1996 : These results indicate that NF-kappa B activity is commonly inducible in DND39 cells by IL-4 and anti-CD40 mAb and suggest that NF-kappa B sensitive to NAC may play a role in regulating IgE synthesis in B cells
Pindolia et al., Hematopathol Mol Hematol 1996 : Furthermore, while unable to induce the activation of NF-kB alone, IL-4 enhanced the activation of NF-kB by IL-1
De Valck et al., Biochem Biophys Res Commun 1997 : However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit NF-kappaB activation induced by tumor necrosis factor, interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Bowie et al., J Biol Chem 1997 : Here we have investigated the effect of a range of putative antioxidants on NF-kappaB activation by interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Chaturvedi et al., J Biol Chem 1997 : As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers
Gri et al., J Biol Chem 1998 (Cell Transformation, Viral) : Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Giri et al., J Biol Chem 1998 (Lymphoma, T-Cell...) : HuT-78 cells were also resistant to NF-kappaB activation induced by phorbol ester, H2O2, ceramide, endotoxin, and interleukin-1
Clarke et al., Eur J Immunol 1998 : Therefore we conclude that although IL-10 or IL-4 can suppress NF kappa B activity, this appears to have little effect on the expression of the TNF-alpha gene and is unlikely to be the basis of the anti-inflammatory effects of these cytokines
Heitmeier et al., J Biol Chem 1998 : Double stranded RNA induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation
Nakazato et al., Kidney Int 1998 : In contrast, IL-4 did not affect basal and IL-1 induced NF-kappa B activities
Schwager et al., Vet Immunol Immunopathol 1998 (Ascorbic Acid Deficiency...) : The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor NF-kappa B is sensitive to ROI and regulates the expression of interleukin genes
Jeppson et al., J Immunol 1998 : These data indicate that both IL-4 and anti-CD40 are required to induce NF-kappa B activation and IL-6 transcription and production, and implicate these events in a signaling pathway augmenting IgE production in human B lymphocytes
Béraud et al., Proc Natl Acad Sci U S A 1999 : The compound had virtually no effect on tumor necrosis factor- and interleukin-1 induced NF-kappaB activities